Acne, the microbiome and innate immunity

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Abstract


In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant improvement of acne in a series of 74 acne patients.

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About the authors

Marius-Anton A Ionescu

University Paris VII

Email: dr.toni.ionescu@gmail.com
1, Avenue Claude Vellefaux, 75745 Paris cedex 10, France
MD, PhD, Dermatology Outpatient Clinic University Hospital “Saint-Louis” Paris VII

M. Feuiolley

Universite de Rouen


Laboratoire de microbiologie, signaux et microenvironnement EA 4312

J. Enault

Universite de Rouen


Laboratoire de microbiologie, signaux et microenvironnement EA 4312

P. Wolkenstein

University Paris XII

Creteil
Dermatology Department, University Hopsital Henry Mondor

G. Robert

R&D, Laboratoires Dermatologiques d’Uriage

Neuilly-sur-Seine, France

L. Lefeuvre

R&D, Laboratoires Dermatologiques d’Uriage

Neuilly-sur-Seine, France

References

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  4. Wolkenstein P., Grob J.J., Bastuji-Garin S., Ruszczynski S., Roujeau J.C., Revuz J.; Société Française de Dermotologie. French people and skin diseases: results of a survey using a representative sample. Arch. Dermatol. 2003; 139(12): 1614-9.
  5. Di Landro A., Cazzaniga S., Parazzini F., Ingordo V., Cusano F., Atzori L., et al.; GISED Acne Study Group. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J. Am. Acad. Dermatol. 2012; 67(6): 1129-35. doi: 10.1016/j.jaad.2012.02.018.

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Copyright (c) 2016 Ionescu M.A., Feuiolley M., Enault J., Wolkenstein P., Robert G., Lefeuvre L.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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