FEATURES OF THE APPLICATION OF ENZYME PREPARATIONS FOR THE TREATMENT AND PREVENTION OF POSTACNE

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Abstract


Postacne is a frequent consequence of vulgar acne. In our research the possibility of using hyaluronidase-based medication with prolonged action was considered. Materials and methods. Type of study: randomized, double-blind, placebo-controlled, comparative in parallel groups. 78 patients aged 18 to 35 years with moderate and severe acne vulgaris and postacne scarring were observed, patients were divided into 2 groups of 39 each by randomization. The first group received Bovhyaluronidase + Azoximer (HA) 3000 ME, the second group received a placebo. In accordance with the method of administration within the groups, patients were divided into subgroups. The drug or placebo was administered by intramuscular injection into the gluteus muscle (N = 10, 1 per 3 days) or by ultraphoonophoresis (N = 15, daily). Evaluation of the skin was performed by confocal laser scanning microscopy (CLSM) in vivo (VivaScope 1500, “Lucid Inc.”, USA) and laser Doppler flowmetry (LDF) (LAKK-01 laser capillary blood flow analyzer, “LAZMA”, Russia). The effectiveness was evaluated by the Qualitative scaring grading system and Goodman’s quantitative global acne scarring system. Results. With the use of Bovhyaluronidase + Azoximer 3000 ME improvement was in 84.6%, 5.13% of patients had a significant improvement. In the placebo group the reduction of indices was insignificant. In the drug group a statistically significant change in the microcirculation index (flux) was established. In the placebo group the dynamics of flux was less pronounced. CLSM results showed a significant decrease in fibrosis and inflammatory infiltration in the scar area in the BGA group. In inflammatory areas was reduction of fibrosis and vasodilation. In the placebo group these changes were less pronounced.

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About the authors

Mariya N. Ostretsova

I.M. Sechenov First Moscow State Medical University

Email: mostretsova@gmail.com
Moscow, 119991, Russian Federation
dermatologist, postgraduate student, of department of skin and venereal deseases of I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federation

E. S Snarskaya

I.M. Sechenov First Moscow State Medical University

Moscow, 119991, Russian Federation

S. B Tkachenko

Russian Medical Academy of Continuing Professional Education

Moscow, 125993, Russian Federation

A. S Allenova

I.M. Sechenov First Moscow State Medical University

Moscow, 119991, Russian Federation

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Copyright (c) 2017 Ostretsova M.N., Snarskaya E.S., Tkachenko S.B., Allenova A.S.

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