PSORIASIS IN HIV-INFECTED PATIENTS: CLINICAL AND LABORATORY EVALUATION, APPROACHES TO THERAPY

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Abstract


Clinical and laboratory evaluation of the effectiveness of therapy of psoriasis vulgaris in 78 HIV-infected patients using the two treatment regimens is presented. Peculiarities of clinical course of psoriasis depending on the number of CD4+lymphocytes in the peripheral blood are shown. Histological and histochemical studies of biopsy samples from psoriatic skin lesions and apparently healthy skin in 15 people were performed. The dynamics before and after treatment of CD4+ and CD8+ lymphocytes in biopsies of skin and blood, their relationship with the index of severity of psoriasis (PASI) are presented. This study is of theoretical and practical interest in understanding the value and role of CD4+ and CD8+ lymphocytes in the formation of inflammatory reactions in the skin of patients with psoriasis as a possible option for treatment of psoriasis in HIV-infected patients.

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About the authors

Evgeny Yu. Evdokimov

Central Research Institute of Epidemiology

Email: evdokimovevg@yandex.ru
Moscow, 111123, Russian Federation
MD, PhD, researcher of clinical department Central Research Institute of Epidemiology, Moscow, 111123, Russian Federation.

A. V Sundukov

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Moscow, 127473, Russian Federation

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