Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Purpose. To study morphological reaction of skin to subdermalny introduction of monofilamentny threads from a polidioksanon (PDO). Material and methods. The research is conducted on 14 white rats females of 3-months age. To the area of a back, to the right of a spine column, is 2 cm higher than a tail, about 4 threads from a PDO, in parallel each other, at distance of 1-1.5 mm are implanted. Wool in the field of implantation is shaved, rules of an asepsis and antiseptics are observed. 21 days of a rat later are humanely hammered, fragments of skin of 1.5 × 1.5 cm in size are withdrawn for a histologic research. As control intact samples of skin from the opposite side from a spine column are taken. Results. The received results of a morphological research show that use of threads/sutural material from a PDO has well expressed stimulating effect on collagenogenesis and angiogenesis. For 21 days after introduction of PDO of threads increase in the regenerator activity of cages of a fibroblastichesky row with increase in synthesis of a fibrous component of an intercellular matriks and also lack of ekssudativny inflammation which is poorly expressed by inflammatory infiltration by cages only lympho-plasmacytic a row, lack of allergic reaction, formation of granulomas and the expressed fibrosis is noted. It demonstrates to good regenerator activity of fabrics in reply introduction of threads from a PDO in 21 days.

Full Text

Restricted Access

About the authors

E. V Shtyrkova

Medical University” Reaviz”

Samara, 443001, Russian Federation

S. V Poletaeva

Medical University” Reaviz”

Samara, 443001, Russian Federation

A. V Medvedeva

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

T. V Palatova

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

A. V Morrison

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

Vladimir V. Maslyakov

Medical University” Reaviz”

Samara, 443001, Russian Federation
MD, PhD, DSc., professor, Medical University “Reaviz”, Samara, 443001, Russian Federation

A. A Supilnikov

Medical University” Reaviz”

Samara, 443001, Russian Federation


  1. Аравийская Е.Р. Возрастные изменения в дерме: новые сведения и пути коррекции с помощью средств ежедневного ухода. Русский медицинский журнал. 2008; 16(8): 574-575.
  2. Гелашвили П.А., Супильников А.А., Плохова В.А. Кожа человека (анатомия, гистология, гистопатология). Самара: Самарский медицинский институт «Реавиз»; 2013.
  3. Имаева Н.А., Потекаев Н.Н., Ткаченко С.Б., Шугинина Е.А. Особенности нарушения микроциркуляции при различных типах старения кожи. Кардиоваскулярная терапия и профилактика. 2008; 7(3): 107-110.
  4. Дубовик А.А. Кровоснабжение кожи пожилых людей. Косметические средства. 2016; (4): 4-9.
  5. Соловьева Е.В., Юсова Ж.Ю., Иванова М.А. Инволюционные изменения кожи и микроциркуляторного русла. Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. 2012; 20 (22-2): 97-100.
  6. Петров В.В. Клетки и кровеносные сосуды дермы человека в онтогенезе. Казань; 2015.
  7. Ахтямов С.Н., Кягова А.А. Клинико-морфологические особенности старения кожи. Вестник дерматологии и венерологии. 2005; (4): 60-4.
  8. Мантурова Н.Е., Городилов Р.В., Кононов А.В. Старение кожи: механизмы формирования и структурные изменения. Анналы пластической, реконструктивной и эстетической хирургии. 2010; (1): 88-92.
  9. Головатая И.В., Неробеев А.А., Радион Е.В. Нитевые технологии: взаимодействие биорезорбируемых нитей с мягкими тканями. Kosmetik International. 2015; (3): 100-106.
  10. Amuso D., Amore R., Iorio E.L., Dolcemascolo R., Bonetti L., Leonardi V. Histological evaluation of a biorevitalisation treatment with PDO wires. Aesthet. Med. 2015; 1(3): 111-7
  11. Lee H., Yoon K., Lee M. Outcome of facial rejuvenation with polydioxanone thread for Asians. J. Cosmet. Laser Ther. 2018; 20(3): 189-92.
  12. Kurita M., Matsumoto D., Kato H., Araki J., Higashino T., Fujino T., et al. Tissue reactions to cog structure and pure gold in lifting threads: a histological study in rats. Aesthet. Surg. J. 2011; 31(3): 347-51.
  13. Moulonguet I., Arnaud E., Plantier F., da Costa P., Zaleski S. Histopathologic and ultrastructural features of gold thread implanted in the skin for facial rejuvenation. Am. J. Dermatopathol. 2015; 37(10): 773-7.
  14. Kim H., Bae I.H., Ko H.J., Choi J.K., Park Y.H., Park W.S. Novel polydioxanone multifilament scaffold device for tissue regeneration. Dermatol. Surg. 2016; 42(1): 63-7.
  15. Suh D.H., Jang H.W., Lee S.J., Lee W.S., Ryu H.J. Outcomes of polydioxanone knotless thread lifting for facial rejuvenation. Dermatol. Surg. 2015; 41(6): 720-5.
  16. Yun H.J., Lee H.J. Numerous linear metallic densities on radiograph: Gold threads. J. Postgrad. Med. 2016; 62(3): 208. doi: 10.4103/0022-3859.168267.
  17. Кодяков А.А., Федоров П.Г. Тенденции эстетической медицины и нитевые методы омоложения. Инъекционные методы в косметологии. 2017; (1): 4-10



Abstract - 35

PDF (Russian) - 0


Article Metrics

Metrics Loading ...



Copyright (c) 2018 Shtyrkova E.V., Poletaeva S.V., Medvedeva A.V., Palatova T.V., Morrison A.V., Maslyakov V.V., Supilnikov A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies