MORPHOLOGICAL REACTION OF SKIN TO SUBDERMALNY INTRODUCTION OF MONOFILAMENTNY THREADS FROM A POLIDIOKSANON

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Abstract


Purpose. To study morphological reaction of skin to subdermalny introduction of monofilamentny threads from a polidioksanon (PDO). Material and methods. The research is conducted on 14 white rats females of 3-months age. To the area of a back, to the right of a spine column, is 2 cm higher than a tail, about 4 threads from a PDO, in parallel each other, at distance of 1-1.5 mm are implanted. Wool in the field of implantation is shaved, rules of an asepsis and antiseptics are observed. 21 days of a rat later are humanely hammered, fragments of skin of 1.5 × 1.5 cm in size are withdrawn for a histologic research. As control intact samples of skin from the opposite side from a spine column are taken. Results. The received results of a morphological research show that use of threads/sutural material from a PDO has well expressed stimulating effect on collagenogenesis and angiogenesis. For 21 days after introduction of PDO of threads increase in the regenerator activity of cages of a fibroblastichesky row with increase in synthesis of a fibrous component of an intercellular matriks and also lack of ekssudativny inflammation which is poorly expressed by inflammatory infiltration by cages only lympho-plasmacytic a row, lack of allergic reaction, formation of granulomas and the expressed fibrosis is noted. It demonstrates to good regenerator activity of fabrics in reply introduction of threads from a PDO in 21 days.

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About the authors

E. V Shtyrkova

Medical University” Reaviz”

Samara, 443001, Russian Federation

S. V Poletaeva

Medical University” Reaviz”

Samara, 443001, Russian Federation

A. V Medvedeva

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

T. V Palatova

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

A. V Morrison

Saratov State Medical University n.a. V.I. Razumovsky

Saratov, 410012, Russian Federation

Vladimir V. Maslyakov

Medical University” Reaviz”

Email: maslyakov@inbox.ru
Samara, 443001, Russian Federation
MD, PhD, DSc., professor, Medical University “Reaviz”, Samara, 443001, Russian Federation

A. A Supilnikov

Medical University” Reaviz”

Samara, 443001, Russian Federation

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Copyright (c) 2018 Shtyrkova E.V., Poletaeva S.V., Medvedeva A.V., Palatova T.V., Morrison A.V., Maslyakov V.V., Supilnikov A.A.

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