Promising fields in the study of the pathogenesis of necrobiosis lipoidica

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Abstract

The diagnosis of necrobiosis lipoidica is gaining significance owing to the increase in the incidence of diabetes mellitus. Several theories regarding the etiopathogenesis of necrobiosis lipoidica indicate the distinctive role of transport proteins of the Glut family, as well as the role of matrix metalloproteinase in the development of this dermatosis.

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About the authors

N. P. Teplyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: koroleva_v_s1@student.sechenov.ru
ORCID iD: 0000-0002-5800-4800

Department of Dermatology and Venerology of Institute of Clinical Medicine n.a. N.V. Sklifosovsky

Russian Federation, 119991, Moscow

N. L. Shimanovskiy

Pirogov Russian National Research Medical University

Email: koroleva_v_s1@student.sechenov.ru

Department of Molecular Pharmacology and Radiobiology

Russian Federation, Moscow, 117997

V. A. Varshavsky

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: koroleva_v_s1@student.sechenov.ru
ORCID iD: 0000-0002-5855-3092

Department of Pathological Anatomy n.a. Acad. A.I. Strukova Institute of Clinical Medicine n.a. N.V. Sklifosovsky

Russian Federation, 119991, Moscow

V. S. Koroleva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: koroleva_v_s1@student.sechenov.ru
ORCID iD: 0000-0002-9945-7830

MD, postgraduate of Department of Dermatology and Venerology

Russian Federation, 119991, Moscow

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Supplementary files

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2. Fig. 1. The clinical picture of a typical papular form of necrobiosis lipoid: there is a papule of rounded outlines with clear boundaries.

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3. Fig. 2. The clinical picture of a formed plaque with central atrophy in a patient with necrobiosis lipoid.

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4. Fig. 3. Histological specimen. Lymphohistiocytic infiltrate around the area of collagen necrobiosis.

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5. Fig. 4. Histological specimen. Extracellular lipid deposition.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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