Cutaneous manifestations of new coronavirus infection (COVID-19)

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Abstract


This article presents the recently published data on the pathogenesis and cutaneous manifestations of the new coronavirus infection (COVID-19). The main symptoms of COVID-19 have already been well studied. However, recently, some reports on cutaneous manifestations (urticaria, papulae and vesicles, erythematous rash, purpura, livedo-angiitis, eruptive angioma, chilblain-like rash, pityriasis rosea, erythema multiforme, and periorbital dyschromia) in patients with COVID-19 have been made. Moreover, the healthcare professionals using personal protective equipment more frequently may develop occupational dermatoses.


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About the authors

Olga Yu. Olisova

First Moscow State Medical Uiversity n.a. I.M. Sechenov (Sechenov University)

Author for correspondence.
Email: Olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754

Russian Federation, 119991, Moscow, Russian Federation

MD, PhD, DSc, professor, head. Department of Skin and Sexually Transmitted Diseases 

E. S. Snarskaya

I.M.Sechenov First Moscow Medical University (Sechenov University)

Email: Olisovaolga@mail.ru
ORCID iD: 0000-0002-7968-7663

Russian Federation, Moscow, 119991

Department of Skin and Venereal Diseases

E. M. Anpilogova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: olisovaolga@mail.ru
ORCID iD: 0000-0001-9478-5838

Russian Federation, Moscow, 119991

Department of Dermatology and Venerology

References

  1. Yuefei Jin, Haiyan Yang, Wangquan Ji, Weidong Wu, Shuaiyin Chen, Weiguo Zhang. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020; 12(4): 372. doi: 10.3390/v12040372.
  2. COVID-19 Maps. Johns Hopkins University. Medicina. Coronavirus Resource Center. Available at: https://coronavirus.jhu.edu/map.html. Published May 24, 2020. Accessed May 24, 2020.
  3. Wei Ji, Wei Wang, Xiaofang Zhao, J unjie Zai, Xingguang Li. Cross-species transmission of the newly identified coronavirus 2019-nCoV. J. Med. Virol. 2020; 92(4): 433-40. doi: 10.1002/jmv.25682.
  4. Fei Zhou, Ting Yu, Ronghui Du, Guohui Fan, Ying Liu, Zhibo Liu, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229): 1054-62. doi: 10.1016/S0140-6736(20)30566-3.
  5. Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R. Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age. ACS Chem Neurosci. 2020. doi: 10.1021/acschemneuro.0c00210. Online ahead of print.
  6. Xiowei Li, Manman Geng, Yizhao Peng, Liesu Meng, Shemin Lu. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020; 10(2): 102-8. doi: 10.1016/j.jpha.2020.03.001
  7. Kubanov A.A., Deryabin D.G. A new look at the COVID-19 pathogenesis: the disease is a generalized viral vasculitis, and the lung tissue damage is a variant of angiogenic pulmonary edema. Annals of the Russian Academy of Medical Sciences. Russian Journal (Vestnik RAMS). 2020;75(2):96-8. doi: 10.15690/vramn1347
  8. Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. J Eur Acad Dermatol Venereol. 2020;34(5):e212-3. doi: 10.1111/jdv.16387.
  9. Galvan Casas C, Catala A, Carretero Hernandez G, Rodriguez-Jimenez P, Fernandez Nieto D, Rodriguez-Villa Lario A, et al. Classification of the cutaneous manifestations of COVID-19: A rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020. doi: 10.1111/bjd.19163. Online ahead of print.
  10. Diotallevi F., Campanati A., Bianchelli T., Bobyr I., Luchetti M.M., Marconi B. et al. Skin involvement in SARS-CoV-2 infection: case series. J Med Virol. 2020. doi: 10.1002/jmv.26012. Online ahead of print.
  11. Wen Zhang, Yan Zhao, Fengchun Zhang, Qian Wang, Taisheng Li, Zhengyin Liu, et al. The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the perspectives of clinical immunologists from China. Clin Immunol. 2020; 214: 108393. doi: 10.1016/j.clim.2020.108393.
  12. Castelnovo L., Capelli F., Tamburello A., Faggioli P., Mazzone A. Symmetric cutaneous vasculitis in COVID-19 pneumonia. J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16589. Online ahead of print.
  13. Cepeda-Valdes R., Carrion-Alvarez D., Trejo-Castro A., Hernandez-Torre M., Salas-Alanis J. Cutaneous manifestations in COVID-19: family cluster of urticarial rash. Clin Exp Dermatol. 2020. doi: 10.1111/ced.14290. Online ahead of print.
  14. de Medeiros V., Silva L. Follow-up of skin lesions during the evolution of COVID-19: a case report. Arch Dermatol Res. 2020. doi: 10.1007/s00403-020-02091-0. Online ahead of print.
  15. Henry D., Ackerman M., Sancelme E., Finon A., Esteve E. Urticarial eruption in COVID-19 infection J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16472. Online ahead of print.
  16. Naziroglu T., Sozen S., Ozkan P., Seker S., Aksu K. A case of COVID-19 pneumonia presenting with acute urticaria. Dermatol Ther. 2020. doi: 10.1111/dth.13575. Online ahead of print.
  17. Zhang Y., Cao W., Xiao M., Li Y.J., Yang Y., Zhao J. et al. Clinical and coagulation characteristics of 7 patients with critical COVID-2019 pneumonia and acro-ischemia. Zhonghua Xue Ye Xue Za Zhi. 2020; 41(0): E006. doi: 10.3760/cma.j.issn.0253-2727.2020.0006. Online ahead of print.
  18. Landa N., Mendieta-Eckert M., Fonda-Pascual P., Aguirre T. Chilblain-like lesions on feet and hands during the COVID-19 Pandemic. Int J Dermatol. 2020; 59(6): 739-43. doi: 10.1111/ijd.14937.
  19. Ahouach B., Harant S., Ullmer A., Martres P., Begon E, Blum L. et al. Cutaneous lesions in a patient with COVID-19: are they related? Br J Dermatol. 2020. doi: 10.1111/bjd.19168. Online ahead of print.
  20. Carreras-Presas C.M., Sanchez J.A., Lopez-Sanchez A.F., Jane-Salas E., Perez M.L. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis. 2020. doi: 10.1111/odi.13382.
  21. Online ahead of print.
  22. Diaz-Guimaraens B., Dominguez-Santas M., Suarez-Valle A., Pindado-Ortega C., Selda-Enriquez G., Bea-Ardebol S., et al.
  23. Petechial skin rash associated with severe acute respiratory syndrome coronavirus 2 infection. JAMA Dermatol. 2020.
  24. doi: 10.1001/jamadermatol.2020.1741. Online ahead of print.
  25. Fernandez-Nieto D., Ortega-Quijano D., Jimenez-Cauhe J., Burgos-Blasco P., de Perosanz-Lobo D., Suarez-Valle A., et al. Clinical and histological characterization of vesicular COVID-19 rashes: A prospective study in a tertiary care hospital. Clin Exp Dermatol. 2020. doi: 10.1111/ced.14277. Online ahead of print.
  26. Jimenez-Cauhe J., Ortega-Quijano D., Carretero-Barrio I.,
  27. Suarez-Valle A., Saceda-Corralo D., C Moreno-Garcia C. Erythema multiforme-like eruption in patients with COVID-19 infection: clinical and histological findings. Clin Exp Dermatol. 2020. doi: 10.1111/ced.14281. Online ahead of print.
  28. Sokumbi O., Wetter D. Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist Int J Dermatol. 2012; 51(8): 889-902. doi: 10.1111/j.1365-4632.2011.05348.x
  29. Kalner S., Vergilis I.J. Periorbital erythema as a presenting sign of COVID-19. JAAD Case Rep. 2020. doi: 10.1016/j.jdcr.2020.05.001. Online ahead of print.
  30. Sachdeva M., Gianotti R., Shah M., Lucia B., Tosi D., Veraldi S., et al. Cutaneous manifestations of COVID-19: report of three cases and a review of literature. J Dermatol Sci. 2020; S0923-1811(20)30149-3. doi: 10.1016/j.jdermsci.2020.04.011.
  31. Online ahead of print.
  32. Joob B., Wiwanitkit V. COVID-19 can present with a rash and be mistaken for dengue. J Am Acad Dermatol. 2020; 82(5): e177. doi: 10.1016/j.jaad.2020.03.036.
  33. Paolino G., Canti V., Mercuri S.R., Querini P.R., Candiani M., Pasi F. Diffuse cutaneous manifestation in a new mother with COVID-19 (SARS-Cov-2). Int J Dermatol. 2020. doi: 10.1111/ijd.14919. Online ahead of print.
  34. Ehsani A.H., Nasimi M., Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16579. Online ahead of print.
  35. de Masson A., Bouaziz J.D., Sulimovic L., Cassius C., Jachiet M., Ionescu M.A., et al.; SNDV (French Union of Dermatologists-Venereologists). Chilblains are a common cutaneous finding during the COVID-19 pandemic: a retrospective nationwide study from France. J Am Acad Dermatol. 2020; S0190-9622(20)30789-1. doi: 10.1016/j.jaad.2020.04.161. Online ahead of print.
  36. Cordoro K., Reynolds S., Wattier R., McCalmont T. Clustered Cases of Acral Perniosis: Clinical Features, Histopathology and Relationship to COVID-19 Pediatr Dermatol. 2020.
  37. doi: 10.1111/pde.14227. Online ahead of print.
  38. Locatelli A.G., Test E.R., Vezzoli P., Carugno A, Moggio E, Consonni L, et al. Histologic features of long lasting chilblain-like lesions in a pediatric COVID-19 patient. J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16617. Online ahead of print.
  39. Ruggiero G., Arcangeli F., Lotti T. Therapy for probable COVID-19 associated erythema pernio-like lesions in pediatric age. Case report. Dermatol Ther. 2020;e13616. doi: 10.1111/dth.13616. Online ahead of print.
  40. Duramaz B.B., Yozgat C.Y., Yozgat Y., Turel O. Appearance of skin rash in pediatric patients with COVID-19: Three case presentations. Dermatol Ther. 2020; e13594. doi: 10.1111/dth.13594. Online ahead of print.
  41. Andina D., Noguera-Morel L., Bascuas-Arribas M., Gaitero-Tristan J., Alonso-Cadenas J.A., Escalada-Pellitero S., et al.
  42. Chilblains in children in the setting of COVID-19 pandemic.
  43. Pediatr Dermatol. 2020. doi: 10.1111/pde.14215. Online ahead of print.
  44. Elston D. Occupational skin disease among health care workers during the coronavirus (COVID-19) epidemic. J Am Acad
  45. Dermatol. 2020;82(5):1085-6. doi: 10.1016/j.jaad.2020.03.012.
  46. Gheisari M, Araghi F, Moravvej H, Tabary M, Dadkhahfar S. Skin reactions to non-glove personal protective equipment: an emerging issue in the COVID-19 pandemic. J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16492. Online ahead of print.
  47. Singh M., Pawar M., Bothra A., Maheshwari A., Dubey V., Tiwari A., Kelati A. Personal protective equipment induced facial dermatoses in healthcare workers managing COVID-19 cases. J Eur Acad Dermatol Venereol. 2020. doi: 10.1111/jdv.16628. Online ahead of print.
  48. Lan J., Song Z., Miao X., Li H., Li Y., Dong L., et al. Skin damage among health care workers managing coronavirus
  49. disease-2019. J Am Acad Dermatol. 2020; S0190-9622(20)30392-3. doi: 10.1016/j.jaad.2020.03.014. Online ahead of print.
  50. Zhang B., Zhai R., Ma L. COVID-19 epidemic: Skin protection for health care workers must not be ignored. J Eur Acad
  51. Dermatol Venereol. 2020. doi: 10.1111/jdv.16573. Online ahead of print.
  52. Kwon K.T., Ko J.H., Shin H., Sung M., Kim J.Y. Drive-through screening center for COVID-19: a safe and efficient screening system against massive community outbreak. J Korean Med Sci. 2020; 35(11): e123. doi: 10.3346/jkms.2020.35.e123.
  53. Alenius H, Turjanmaa K, Palosuo T. Natural rubber latex allergy. Occup Environ Med. 2002;59(6):419-24.
  54. Bolognia J.L., Schaffer J.V., Cerroni L. Dermatology. 4th ed. Elsevier Health Sciences; 2018.
  55. Hamming I., Timens W., Bulthuis M.L., Lely A.T., Navis G.J., van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004; 203(2): 631-7. doi: 10.1002/path.1570

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Copyright (c) 2020 Olisova O.Y., Snarskaya E.S., Snarskaya E.S., Anpilogova E.M., Anpilogova E.M.

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