Biological drugs prescription issues in terms of the new coronaviral infection COVID-19 pandemic. Literature review and clinical case

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BACKGROUND: The spread of the novel coronaviral infection has set important medical society goals, such as the development of effective treatment and preventive modalities (including biologic agents) for COVID-19. Moreover, during this pandemic, the management of chronically ill patients that require immunosuppressive therapy is also a matter of great concern. Analysis of currently obtained data has concluded that patients treated with biologic agents have no elevated risk for COVID-19. Leading medical societies give an opinion in their clinical guidelines that management with biologic drugs should be continued during the COVID-19 pandemic. The feasibility of initiating treatment with a biologic agent depends on the risk-benefit ratio for the drug, the assessment of possible complications along with the associated risks for a poor outcome because of an underlying disease.

CASE REPORT: We present a case report of a patient with erythrodermic psoriasis and psoriatic arthritis treated with ixekizumab during COVID-19 quarantine.

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About the authors

L. S. Kruglova

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

ORCID iD: 0000-0002-5044-5265

Russian Federation, Moscow

E. A. Shatokhina

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

ORCID iD: 0000-0002-0238-6563

Russian Federation, Moscow

Alexandra S. Polonskaya

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

Author for correspondence.
ORCID iD: 0000-0001-6888-4760

Russian Federation, Moscow



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Supplementary files

Supplementary Files Action
Fig. 1. Dynamics of clinical manifestations of psoriasis in patient A. during treatment with a genetically engineered biological drug ixekizumab (TALS).

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Fig. 2. Dynamics of psoriasis severity indices during the course of therapy with ixekizumab in patient A.

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