Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3673310.17816/dv36733Research ArticleMOLECULAR GENETIC IDENTIFICATION OF T-CELL CLONALITY OF LYMPHOID CELLSMolochkovV. A-KovriginaA. M-SidorovaYu. V.-MenshchikovaG. V.-GroznovaA. Aanna_groznova@list.ruFedorovskayaA. V.-M.V. Vladimirsky Moscow Regional Research and Clinical InstituteI.M.Sechenov Moscow State Medical UniversityHematology Research Center, Moscow1504201316221072020Copyright © 2013, Eco-Vector2013The authors discuss problems in improvement of early diagnosis of T- and B-cell cutaneous lymphomas and differential diagnose from large-plaque parapsoriasis, T- and B-cell cutaneous pseudolymphomas, and evaluate the incidence of their transformation into malignant skin lymphomas.malignant skin lymphomaspolymerase chain reactionclonalityT-cell receptorзлокачественные лимфомы кожиполимеразная цепная реакцияклональностьТ-клеточный рецептор[Никитин Е.А., Сидорова Ю.В., Рыжикова Н.В., Бидерман Б.В., Меликян А.Л., Виноградова Ю.Э. и др. Определение Т-клеточной клональности по гамма-цепи Т-клеточного рецептора: окончательные данные. Терапевтический архив. 2006; 7: 52—7.][Овсянникова Г.В. Современные методы комплексной диагностики злокачественных лимфом кожи: Автореф. дис.. канд. мед. наук. М.; 2009.][Delabesse E., Burtin M.-L., Millien С., Madonik A., Arnulf B., Beldjord K., et al. Rapid, multifluorescent TCRG Vgamma and Jgamma typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. Leukemia. 2000; 14(6): 1143—52.][Greiner T.C., Raffeld M., Lutz C., Dick F., Jaffe E.S. Analysis of T-cell receptor-gamma gene rearrangements by denaturing gradient gel electrophoresis of GC-clamped polymerase chain reaction products: correlation with tumor-specific sequences. Am. J. Pathol. 1995; 146(1): 46—55.][van Dongen J.J., Langerak A.W., Bruggemann M., Evans P.A., Hummel M., Lavender F.L., et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4 CT98-3936. Leukemia. 2003; 17(12): 2257—317.]