Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3675510.17816/dv36755Research ArticleCD45 IN CUTANEOUS MELANOMA CELLS AS A MANIFESTATION OF TUMOR ATYPIAAksenenkoM. Baksenenko_mariya@mail.ruShestakovaL. Apatholog-lan@yandex.ruRukshaT. Gtatyana_ruksha@mail.ruV.F.Voino-Yasenetsky Krasnoyarsk State Medical University150820131646821072020Copyright © 2013, Eco-Vector2013The expression of CD45 (hemopoietic cell marker) in cutaneous melanoma cells was studied in 96 patients (40 men and 56 women). The expression was detected in 17.5% patients, mainly with Clark’s tumor invasion levels IV and V and Breslow’s thickness of the tumor 3.7±1.09 mm. Data on the relationship between this marker’s expression and clinical morphological characteristics of the disease are presented. The differential diagnosis of cutaneous melanoma is discussed.CD45cutaneous melanomaCD45necrotizationмеланома кожинекротизация[Stoeter D., de Liguori Carino N., Marshall E., Poston G.J., Wu A. Extensive necrosis of visceral melanoma metastases after immunotherapy. World J. Surg. Oncol. 2008; 6: 30. doi: 10.1186/14777819-6-30.][Bachmann I.M., Ladstein R.G., Straume O., Naumov G.N., Akslen L.A. Tumor necrosis is associated with increased alpha-v beta-3 integrin expression and poor prognosis in nodular cutaneous melanomas. BMC Cancer. 2008; 8: 362. doi: 10.1186/1471-2407-8-362.][Judkins A.R., Roberts S.A., Livolsi V.A. Utility of immunohistochemistry in the evaluation of necrotic thyroid tumors. Hum. Pathol. 1999; 30(11): 1373-6.][Chen N., Gong J., Chen X., Xu M., Huang Y., Wang L., et al. Cytokeratin expression in malignant melanoma: potential application of in-situ hybridization analysis of mRNA. Melanoma Res. 2009; 19(2): 87-93.][Aisner D.L., Maker A., Rosenberg S.A., Berman D.M. Loss of S-100 antigenicity in metastatic melanoma. Hum. Pathol. 2005; 36(9): 1016-9.][Saleh F.H., Crotty K.A., Hersey P., Menzies S. W., Rahman W. Autonomous histopathological regression of primary tumors associated with specific immune responses to cancer antigens. J. Pathol. 2003; 200(3): 383-95.][Nonaka D., Laser J., Tucker R., Melamed J. Immunohistochemical evaluation of necrotic malignant melanomas. Am. J. Clin. Pathol. 2007; 127(5): 787-91.][Taetle R., Ostergaard H., Smedsrud M., Trowbridge I. Regulation of CD45 expression in human leukemia cells. Leukemia. 1991; 5(4): 309-14.][Judkins A.R., Montone K.T., Livolsi V.A., van de Rijn M. Sensitivity and specificity of antibodies on necrotic tumor tissue. Am. J. Clin. Pathol. 1998; 110(5): 641-6.]