Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3685710.17816/dv36857Research ArticleEFFECTS OF SURFACE PEELING BY SALICYLIC ACID DERIVATIVES ON PROLIFERATION AND DIFFERENTIATION PROCESSES IN THE SKINKorolkovaT. Ntnkor@mail.ruBalashovaA. Vanna191177@list.ruZinovyevE. Vevz@list.ruI.M.Metchnikov North-Western State Medical UniversityLeningrad Regional Clinical Hospital15022014171535721072020Copyright © 2014, Eco-Vector2014The effects of peeling by β-lipohydroxysalicylic acid (LHA) and salicylic acid (SA) on the expression of tissue markers of proliferation and differentiation in skin cells were studied. Peeling in the retro-auricular regions: on the right side by LHA, on the left by SA was carried out in 5 volunteers treated in burn wards for skin cicatrices formed after previous burns of various skin areas. Biopsy specimens were collected after 1 week in 2 patients, after 10 days in 1 patient, and after 2 weeks in 2 patients. Intact skin biopsy specimens from the retrolateral surface of the neck served as control. The expression of the following markers was studied by the immunohistochemical method: p53 proapoptotic protein, Bcl-2 antiapoptotic protein, Ki-67 proliferating cell marker, and collagen 4. Peeling by LHA and SA differed by their effects on the epidermis and derma. The SA peeling more intensely stimulated the regeneratory processes in the epidermis and derma, which could reflect its more pronounced effect on the skin.peelingβ-lipohydroxysalicylic acidsalicylic acidimmunohistochemistryproliferationapoptosisпилингβ-липогидроксисалициловая кислотасалициловая кислотаиммуногистохимияпролиферацияапоптоз[Ахтямов С.Н., Бутов Ю.С. Практическая дерматокосметология: Учебное пособие. М.: Медицина; 2003: 194—204.][Черноух А.М., Фролов Е.П., ред. Кожа. Строение, функция, общая патология и терапия. М.: Медицина; 1982.][Королькова Т.Н. Патогенез местных изменений при химических пилингах. Сборник статей НПО врачей косметологов. Вып. 9. СПб.; 2008: 29—37.][Ахтямов С.Н. Салициловая кислота. В кн.: Ахтямов С.Н.,ред. Эстетическая медицина: Химический пилинг. Справочное руководство. М.: New Line Cosmetology; 2005: 142—4.][Эрнандес Е.И., Пономарев И.В., Ключарева С.В. Современные пилинги: химический пилинг, лазерная шлифовка, механическая дермабразия, плазменная шлифовка. М.: Косметика и медицина; 2011.][Grimes P.E. The safety and efficacy of Salicylic acid chemical peels in darker racial ethnic groups. Dermatol. Surg. 1999; 25(1): 18—22.][Rubin M.G., Dover J.S., Alam M., eds. Chemical Peels. Elsevier Saunders; 2006.][Kliqman D., Kliqman A.M. Salicylic acid peels for treatment of photoaging. J. Dermatol. Surg. 1998; 24(3): 325—8.][Курбасова Е., Лащинина Е. Мир гидроксикислот. Les Nouvelles Esthetiques. 2010; 1: 26—35.]