Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3707410.18821/1560-9588-2016-19-1-17-20Research ArticlePorphyria cutanea tarda concomitant with chronic hepatitis CTeplyukN. P-VertievaEkaterina Yu.Candidate of Medical Sciences, Research Officerivertieva@gmail.comIgnatyevD. V-DzhavakhishviliI. S-I.M. Setchenov First Moscow State Medical University15022016191172021072020Copyright © 2016, Eco-Vector2016Porphyrias form a group of rare metabolic diseases associated with disorders in the heme biosynthesis enzymes, leading to porphyrin accumulation in tissues. The disease is rare and is often diagnosed too late. The most incident is porphyria cutanea tarda. All patients with this condition should be tested for viral hepatites and hemochromatosis. A clinical case is presented: a patient with porphyria cutanea tarda associated with alcohol abuse and viral hepatitis C.porphyriasporphyria cutanea tardaheme synthesis disordersпорфириипоздняя кожная порфириянарушение синтеза гема[Thadani H., Deacon A., Peters T. Diagnosis and management of porphyria. Br. Med. J. 2000; 320 (7250): 1647-51.][Халдин А.А., Олисова О.Ю., Белоусова Т.А. К вопросу о диагностике поздней кожной порфирии. Российский журнал кожных и венерических болезней. 2004; 6: 32-6.][Lim H.W. Pathogenesis of photosensitivity in the cutaneous porphyrias. J. Invest. Dermatol. 2005; 124(1): 16-7.][Вольф К., Голдсмит Л.А., Кац С.И., Джилкрест Б.А., Паллер Э.С., Леффель Д.Дж. Дерматология Фицпатрика в клинической практике. Пер. с англ. М.: Изд. Панфилова; БИНОМ; 2012. т.2: 1343-74.][Franke K., Fikentscher R. Die Bedeutung der quantitativen Porphyrinbestimmung mit der Lumineszenzmessung für die Prüfung der Leberfunktion und für Ernährungsfragen. Münchener Medizinische Wochenschrift. 1935; 82: 171-2.][Goldberg A., Rimington C. Diseases of porphyrin metabolism. Illinois: Thomas Springfield; 1962: 19-20.][Bloomer J.R. The hepatic porphyries: pathogenesis, manifestations, and management. Gastroenterology. 1976; 71(4): 689-701.][McColl K.E., Thompson G.G., Moore M.R., Goldberg A. Acute ethanol ingestion and haem biosynthesis in healthy subjects. Eur. J. Clin. Invest. 1980; 10(2, Pt 1): 107-12.][Doss M.O., Kuhnel A., Gross U. Alcohol and porphyrin metabolism. Alcohol. Alcohol. 2000; 35(2): 109-25.][Balwani M., Desnick R.J. The orphyries: advances in diagnosis and treatment. Blood. 2012; 120(23): 4496-504. doi: 10.1182/blood-2012-05-423186.][James M.F., Hift R.J. Porphyrias. Br. J. Anaesth. 2000; 85(1): 143-53.][Palmieri C., Vigushin D.M., Peters T.J. Managing malignant disease in atients with porphyria. Q. J. M. 2004; 97(3): 115-26.][Casanova-Gonzalez M.J., Trapero-Marugan M., Jones E.A., Moreno-Otero R. Liver disease and erythropoietic protoporphyria: a concise review. Wld J. Gastroenterol. 2010; 16(36): 4526-31.]