Vol 15, No 2 (2012)

Articles
PHOTODYNAMIC THERAPY WITH INTERSTITIAL IRRADIATION OF SKIN TUMORS
Skugareva O.A., Popuchiev V.V., Sukhova T.E., Kapinus V.N., Kaplan M.A.
Abstract
Photodynamic therapy with interstitial irradiation was carried out in 21 patients with basal cell and squamous cell carcinomas of the skin (T1—4N0M0). The tumors completely regressed in 76.2% patients, partially regressed in 23.8%. The therapy was ineffective in none of the cases. The results suggest this method for the treatment of large skin tumors of various sites as a monotherapy and in combination with long distance photodynamic therapy.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):4-6
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LASER-INDUCED THERMOTHERAPY OF BASAL CELL CARCINOMA
Molochkov V.A., Molochkov A.V., Romanko Y.S., Belyi Y.A., Akopova K.V., Tretyakova E.I., Sukhova T.E., Popuchiev V.V.
Abstract
Seventy-seven patients with variants of surface and nodular basal cell carcinomas were treated, 31 of these with multiple carcinomas. Laser-induced thermotherapy (LITT) was carried using LAMI semiconductor laser. For multiple basal cell carcinomas, LITT was combined with prospidine therapy. The efficiency of a single LITT exposure of T1N0M0 surface and micronodular basal cell carcinomas and multiple basal cell carcinomas (2-3 surface and/or micronodular tumors, T1N0M0) was 97%. The efficiency of two LITT exposures for T2N0M0 solitary surface ulcerative, nodular basal cell tumors and T1N0M0 multiple tumors with 3 and more foci was 73.8%. In 11 cases cure was attained after 3 LITT sessions.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):6-10
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MORPHOLOGY OF ACTINIC KERATOSIS
Khlebnikova A.N., Bobrov M.A., Selezneva E.V., Changlyan K.A.
Abstract
Actinic keratosis (AK) is a precancer disease of the skin, emerging in skin sites exposed to the sun. It is characterized by local intraepidermal dysplasia of different severity (KIN I — slight, KIN II — moderate, and KIN III — severe). We studied the distribution and morphology of AK histological types. The study was carried out on 30 biopsy specimens from patients. The study showed that the main morphological signs of AK in the epidermis were keratinocyte dysplasia and hyperparakeratosis; changes in the derma were presented by elastosis in all cases. The most prevalent morphological types of solar keratosis were hypertrophic, atrophic, and bovenoid variants. Slight dysplasia (KIN I) was found mainly in atrophic AK, moderate (KIN II) in hypertrophic, and severe (KIN III) only in bovenoid AK.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):10-15
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SKIN MUCINOSIS. ARNDT-GOTTRON’S SCLEROMYXEDEMA
Kuznetsova N.P., Krivosheev B.N., Chashchin A.Y., Krivosheev A.B.
Abstract
The authors review in brief published data on metabolic dermatoses included in the group of idiopathic (primary) skin mucinosis and clearly differentiated as individual nosological entities. A patient with typical clinical signs of Arndt-Gottron ’s scleromyxedema is described. The diagnosis is verified by pathohistological studies of involved skin. Specific features of this case are the emergence and progress of scleromyxedema in the presence of chronic alcoholism and multiple concomitant visceral diseases — diffuse epidemic goiter without thyroid dysfunction (euthyrosis) and the metabolic syndrome (abdominal obesity, arterial hypertension, type 2 diabetes mellitus, and hypertriglyceridemia). Therapeutic strategy in patients with scleromyxedema and concomitant multiple visceral diseases is discussed.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):15-21
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CLINICAL EFFICIENCY OF PSORIASIS TREATMENT USING CRYOTHERAPY
Vasenova V.Y., Butov Y.S., Akhtyamov S.N., Karpova A.V.
Abstract
Combined treatment of patients with disseminated psoriasis vulgaris by cryotherapy and traditional therapy led to clinical cure and significant improvement in 95% cases, with prolongation of remissions to 9 and more months. Cryotherapy led to improvement of cellular and humoral immunity parameters and to stabilization of biochemical values and peripheral circulation.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):21-25
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MODERN APPROACHES TO LOCAL THERAPY OF SEBORRHEIC DERMATITIS
Buravkova A.G., Novikova L.A., Demyanova O.B.
Abstract
Thirty-four patients with seborrheic dermatitis were effectively treated by the Skin-cap drugs. The results are compared with those in the controls, receiving traditional therapy.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):26-28
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COMBINED THERAPY OF CICATRICIAL CHANGES IN THE SKIN USING ENZYMATIC DRUGS
Snarskaya E.S., Korneva L.V., Kryazheva S.S.
Abstract
Multicomponent mechanisms of cicatrization processes are described and experience gained in the use of longidase in therapy of the postacne, hypertrophic cicatrices, striae, and dermatoses associated with pathological cicatrization is presented.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):28-32
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DETECTION OF BORRELIA INFECTION BY AN INNOVATION TEST SYSTEM (IMMUNOCHIP) IN PATIENTS WITH SCLEROATROPHIC LESIONS OF THE SKIN
Molochkov V.A., Chekanova T.A., Markelov M.L., Karan L.S., Snarskaya E.S., Romashkina A.S.
Abstract
The authors review 15 Russian and foreign publications on the diagnosis of tick-born borreliasis by the immunoblotting method. A new Russian immunoblotting test system (immunochip) is described. Thirty-five patients with various scleroatrophic lesions of the skin associated with Borrelia infection, diagnosed by immunoblotting method, were observed.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):32-35
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TOTAL SYSTEMS OXYGEN OZONE THERAPY FOR NECROBIOSIS LIPOIDICA
Teplyuk N.P., Kosheleva I.V., Plieva L.R., Lepekhova A.A.
Abstract
Necrobiosis lipoidica (NL) is often concomitant with diabetes mellitus. Many patients with this condition have aggravated family history for diabetes mellitus and disorders of glucose tolerance. Microangiopathies are the leading pathogenetic factor in the development of NL, which is resistant to therapy. A new method for the treatment of NL by intravenous infusions of ozonated saline combined with trental therapy is suggested.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):35-40
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OBJECTIVE CRITERIA FOR EVALUATION OF THE DESTRUCTIVE PROCESSES INTENSITY IN CHRONIC DERMATOSIS (COMMUNICATION 2)
Volkova E.N., Korotkaya E.A., Morozov S.G., Elistratova I.V.
Abstract
The authors present an algorithm of measurements of immunity values in patients with chronic dermatoses for evaluation of the destructive processes by the activity of leukocytic elastase.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):40-44
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PATHOMIMESIS PRESENTED BY NECROTIC ULCERATIVE LESIONS OF THE LOWER LIMB SKIN
Zavadsky V.N., Kolobanov N.B.
Abstract
A patient with pathomimesis in the form of necrotic ulcerative and hemorrhagic bullous lesions of the lower limb skin is described. The lesions were caused by hypodermic auto-injections of butorphanol tartrate solution mixed with powdered diphenhydramine tablets into the skin and thigh - the patient admitted he was a drug addict.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):44-45
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DARIERS FOLLICULAR DYSKERATOSIS IN A CHILD
Degtyarev O.V., Dumchenko V.V., Shashkova A.A., Alieva E.R.
Abstract
Darier’s follicular dyskeratosis in a 10-year-old girl with involvement of the hairy part of the head, face, trunk, hands, and nails is described. Therapy with neotigasone and local retinoids was effective.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):45-47
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CONTRIBUTION OF TOLL-LIKE RECEPTORS (TLR) — CONGENITAL IMMUNITY STIMULANTS — TO THE PATHOGENESIS OF SOME DERMATOSES
Snarskaya E.S.
Abstract
The functions of Toll-like receptors (TLR) in the skin and their contribution to stimulation of congenital immunity in some chronic dermatoses caused by or complicated by bacterial, viral, or fungal infections are reviewed.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):47-50
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EFFECT OF SELECTIVE PHOTOTHERAPY 311 NM ON SOME PARAMETERS OF IMMUNE STATUS IN PATIENTS WITH CHRONIC DERMATOSES
Monakhov S.A., Korchazhkina N.B., Olisova O.Y., Perminova M.A., Shabliy R.A.
Abstract
Studied the therapeutic efficacy of the selective phototherapy 311 nm in patients with atopic dermatitis (AD) of varying severity. The state of cellular and humoral immunity in patients with AD, treated by SFT 311 nm and detected multidirectional nature of the method, providing immunomodulatory effects on cellular and humoral immunity.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):50-52
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STRUCTURAL AND FUNCTIONAL PARAMETERS OF FACIAL SKIN BEFORE AND AFTER INTRADERMAL INJECTIONS OF HYALURONIC ACID
Gallyamova Y.A., Barinova O.A.
Abstract
Morphofunctional and structural changes in the facial skin were studied in women aged 35—40 years mainly with the small wrinkle aging type before and after biorevitalization course. The patients were examined by instrumental methods. The authors analyze the opinions of the cosmetologist and patients on the efficiency of the procedures. The efficiency of hyaluronic acid drugs and esthetic correction of facial skin is proven.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):52-56
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CONTRIBUTION OF VIRUSES TO THE PATHOGENESIS OF ALOPECIA AREATA (THEORY OF PATHOGENESIS)
Berechikidze T.S., Lomonosov K.M.
Abstract
The viral theory of the pathogenesis of alopecia areata is discussed. Data on the etiological role of viruses in the development of many human diseases, including skin diseases, are presented. Forty patients with alopecia areata and donors were tested for carriership of such prevalent viruses as cytomegalovirus, rubella, varicella and varicella zoster, herpes simplex 1 and 2, Epstein-Barr virus, adenovirus, human herpes 6 and 8 viruses.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):56-58
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TREATMENT OF CICATRICIAL ALOPECIA
Voronkova M.V., Kosheleva I.V., Ivanov O.L., Mareyeva E.B., Perminova M.A.
Abstract
Describes modern ideas of methods of therapy of primary scarry алопеций. Discussed prospects of the use of the method of oxygen-ozone therapy in the complex treatment of this pathology.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):58-60
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PREVENTIVE TREATMENT OF INDIVIDUALS WHO HAD CONTACTS WITH PATIENTS WITH CONTAGIOUS SYPHILIS
Chebotaryov V.V., Amirdzhakhan N.A.
Abstract
Protocols of differentiated preventive azitromycin therapy have been developed for patients with a history of sexual intercourse or close communal contacts with patients with contagious syphilis. Single oral drug doses for incubation periods of up to 14 days were 1 g, up to 1 month 1.5 g, and up to 2 months 2 g. Clinical and serological testing throughout 6 months showed no signs of syphilis in all subjects with a history of contacts. The protocol can be used in practical public health.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):60-64
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The Mystery of two profiles
Monakhov S.A., Shilova N.G.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):64-64
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Extensive ulcerative defects on the anterior shin surface
Snarskaya E.S., Kryazheva S.S., Lavrov A.A.
Russian Journal of Skin and Venereal Diseases. 2012;15(2):65
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