Vol 15, No 5 (2012)

Articles
QUANTITATIVE METHODS FOR EVALUATING THE PROCESS ACTIVITY IN THE DIAGNOSIS AND TREATMENT OF T-CELLULAR SKIN LYMPHOMAS
Moiochkov V.A., Kovrigina A.M., Moiochkov A.V., Karaulov A.V., Menshchikova G.V., Fedorovskaya A.V., Yefimovich I.V.
Abstract
Precise standardized measurements are essentialfor the diagnosis and treatment of Sezary ’s syndrome (mycosis fungoides). The T-cellular skin lymphoma (T-CSL) severity index (SI) has been suggested in 2005. Evaluation of this index is a simple to use quantitative indicator of the disease activity in cases with involvement of many organs and systems (skin, lymph nodes, circulatory system, viscera) and a prognostically significant characteristic in multifactorial analysis. The index, quantitatively reflecting the disease activity in all involved organs and systems, effectively supplements the TNM classification in clinical practice and research.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):4-7
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DIFFERENT APPROACHES TO CLONAL NATURE EVALUATION IN T-CELLULAR SKIN LYMPHOMA
Molochkov V.A., Sidorova Y.V., Menshchikova G.V., Groznova A.A., Fedorovskaya A.V., Yefimovich I.V.
Abstract
The clonal nature of lymphoid cells was evaluated in skin biopsy and peripheral blood specimens from patients with suspected T-cellular skin lymphoma and with large plaque parapsoriasis transforming into mycosis fungoides.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):8-9
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PHOTOCARCINOGENESIS AND PREVENTION OF SKIN CANCER
Snarskaya E.S.
Abstract
The problems of UV radiation and molecular mechanisms of its effects on the skin, determining the development of skin tumors, are discussed. Topical means for photoprotection of the skin are essential for primary prevention. Bariesun, a new series of solar protective means, is presented. Due to synergically working three ingredients, it protects the cellular DNA even in patients with weak atopic skin.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):10-13
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HIGH LEVELS OF STEROID-METABOLIZING ENZYMES IN THE EPIDERMIS OF PATIENTS WITH MELANOCYTIC TUMORS OF THE SKIN
Malyshev A.S., Ruksha T.G., Prokhorenkov V.I.
Abstract
The functioning of the skin as a neuroimmunoendocrine system organ during development of skin tumors received insufficient attention. Many locally produced regulators, for example steroid hormones, modify the intensity of skin cell proliferation. This fact suggests their involvement in the development of pathological processes in the skin. Changes in the epidermal keratinocyte production of steroid hormones in melanocytic tumors of the skin have been evaluated. These changes can be caused by development of these abnormalities. In addition, they suggest the formation of new therapeutic approaches in these diseases.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):13-15
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KERAT ODERMA AS A MANIFESTATION OF PARANEOPLASIA
Teplyuk N.P., Orlova E.V., Novoselova S.V., Grabovskaya O.V., Varshavsky V.A.
Abstract
Lort-Jacob's verrucous nodular keratoderma in a patient aged 70 years with prostatic cancer and Bazex ’ psoriasiform acrokeratosis in a patient aged 59 years in the presence of atypical pulmonary carcinoid with metastases in the liver are described. The diagnostic search included collection of anamnesis and clinical methods.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):16-19
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ATYPICAL DEVELOPMENT OF ACUTE DEVERGIE’S DISEASE
Kryazheva S.S., Snarskaya E.S., Lavrov A.A.
Abstract
A case with transformation of a process, debuting as toxicoderma, into acute erythrodermal form of Devergie ’s disease is described. The efflorescence rapidly regressed in response to combined therapy including neotigasone. A review of 15 Russian and foreign publications is offered.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):19-22
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A SEVERE CASE WITH RELAPSING BULLOUS TOXICODERMA
Olisova O.Y., Khaldin A.A., Teplyuk N.P., Grabovskaya O.V., Ignatyev D.V., Vertieva E.Y.
Abstract
Toxic epidermal necrolysis in a female patient aged 68 years was caused by therapy with SH group containing drugs. The patient was treated by metiprede in the maximum daily dose of 48 mg, which was gradually reduced as a significant improvement was attained.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):22-25
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MODERN APPROACHES TO THE TREATMENT OF CICATRICIAL ALOPECIA
Voronkova M.V., Kosheleva I.V., Ivanov O.L., Mareyeva E.B.
Abstract
The authors present the results of dermatoscopy of the cicatricial alopecia foci in 19 patients with discoid lupus erythematosus with involvement of the hairy part of the head, lichen planus, frontal fibrosing alopecia, and Broca ’s pseudopelade.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):26-29
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A CASE WITH PEMPHIGUS VULGARIS PARALLELED BY GIANT ACANTHOLYTIC SEBORRHEIC KERATOSIS
Moiochkov V.A., Davidenko E.B., Zenkevich E.V., Karzanov O.V., Kupriyanova A.G., Zaidenov V.A., Bobrov M.A., Chernysh E.S.
Abstract
True pemphigus belongs to the group of autoimmune bullous dermatoses of the skin and mucosa, in which the key role is played by circulating autoantibodies (IgG) to the epidermal desmosomal system antigens. The disease is diagnosed by cytological and histological methods, but one of the main diagnostic methods is direct immunofluorescent study of the skin. Autoimmune pemphigus can be a separate disease or be associated with other skin diseases, such as psoriasis vulgaris, psoriasis guttata, lupus erythematosus, Layell ’s syndrome, dermatomyositis, pyogenic granuloma, vitiligo, folliculitis suffodiens. A case with pemphigus vulgaris combination with giant acantholytic seborrheic keratosis, involving the skin of the hairy part of the head, is described. Published data on atypical location ofvegetating pemphigus foci and detection of acantholysis in foci on the skin of the hairy part of the head necessitated differential diagnosis between vegetating pemphigus and pemphigus vulgaris combined with giant seborrheic keratosis. This case demonstrated the necessity of thorough collection of anamnesis and of all studies needed for correct diagnosis.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):29-32
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THE ROLE OF LL-37 ANTIBACTERIAL PEPTIDE IN THE PATHOGENESIS OF PSORIASIS
Pinegin B.V.
Abstract
Published data on the role of LL-37 antibacterial peptide in initiation and inhibition of psoriatic inflammation are reviewed and probable approaches to its therapeutic use are discussed.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):32-37
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ADALIMUMAB IN PSORIASIS: OUR FIRST EXPERIENCE
Kochergin N.G., Potekayev N.N., Smirnova L.M., Serov D.N., Olisova O.Y., Babushkin A.M.
Abstract
Severe refractory psoriasis is often a difficult therapeutic problem. Classical total systems antipsoriatic therapeutic protocols are now supplemented by modern high-technological highly effective biological preparations. Basic data on anticytokine drugs are presented. The results of the first use of adalimumab (the first Russian drug) have demonstrated its high clinical efficiency: dynamic reduction of the psoriasis activity and dissemination index (PASI) and of dermatological quality of life index, good compliancy and convenient use in an outpatient setting.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):37-41
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ULTRASONOGRAPHIC PICTURE OF THE SKIN AND SUBCUTANEOUS FAT IN SO-CALLED CELLULITIS
Bezuglyi A.P., Bikbulatova N.N., Kruglova L.S., Belkov P.A., Khabutdinova N.R., Ektova T.V., Shmatova A.A.
Abstract
The ultrasonographic picture of the skin and subcutaneous fat was studied in 15 healthy women with the typical manifestations of cellulitis, corresponding to stages II-III. The time course of skin status was evaluated by the thickness of the derma, acoustic compactness of subcutaneous fat, and length of the borderline between the derma and subcutaneous fat.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):42-44
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CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF TOXICODERMA, INCLUDING THAT WITH SECONDARY PYODERMA
Udzhukhu V.Y., Medvedeva A.S., Ivanokova M.A.
Abstract
The role of immunometabolic disorders in the development of drug-induced toxicoderma was studied. A total of 59 patients with clinical variants of toxicoderma were observed. Immunological studies detected disorders in the immune homeostasis, characterized by disproportion of the cytokine profile, adhesion molecules, and Toll-like receptors, as well as in natural resistance of patients with toxicoderma.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):44-46
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SYSTEMIC ISOTRETINOIN THERAPY OF ACNE VULGARIS (REVIEW OF LITERATURE)
Borovaya A.S., Olisova O.Y.
Abstract
This paper presents published data on systemic isotretinoin therapy for acne in Russia and in foreign countries and the modern protocols for acne treatment with standard and low doses of the drug. Isotretinoin combinations with other systemic or local drugs (oral contraceptives, topical antibiotics, retinoids) seem to be promising. High efficiency and safety of isotretinoin in the treatment of severe, medium severe, and slight acne is proven clinically and by laboratory findings.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):47-51
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ISIDA LIPOSOMAL LINE FOR COMPLEX CARE OF COMBINED AND FAT SKIN
Snarskaya E.S., Surikova N.S., Chubatova S.V.
Abstract
Some problems in the etiology and pathogenesis of chronic dermatoses (acne, seborrheic dermatitis, psoriasis) are discussed. Modern data on the treatment and therapeutic and cosmetological care are discussed with consideration for skin type and pathological process location and variant. Isida, a new line for therapeutic and cosmetic care, is presented. It has been created for fat and mixed type skin with manifestations of acne, psoriasis of the hairy part of the head, seborrheic dermatitis variants. Therapeutic care is recommended during and after treatment of the underlying dermatosis and is aimed at rapid resolution of the inflammatory process and prevention of subsequent exacerbations.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):52-55
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GENETIC ASPECTS OF VITILIGO
Simonova N.I., Lomonosov K.M., Babeshko O.A.
Abstract
Modern data on the genetic aspects ofvitiligo epidemiology are presented. Vitiligo is an extensive genetically programmed autoimmune disease. Due to modern potentialities of clinical genetics, international studies have been carried out, aimed at detection of the genes involved in the formation of liability to this abnormality. The studies have been focused on the gene expression, associations of candidate gene alleles, and analysis of gene coupling in the genome in order to detect the new genes.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):56-59
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Pregnancy stigmata
Monakhov S.A.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):60-60
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Nodules on the right shin skin
Tarasenko G.N., Gryazeva N.V., Tarasenko Y.G., Smirnova Y.A.
Russian Journal of Skin and Venereal Diseases. 2012;15(5):60
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