Vol 15, No 4 (2012)

Paraneoplastic diseases of the skin are classifi ed into obligate, probable, and facultative. Leveres bullous pemphigoid (BP) is referred to facultative ones. Analysis of 67 cases with BP of paraneoplastic genesis (by publications of U.S. National Library of Medicine) detected gastrointestinal cancer in 18 (27%), breast cancer in 12 (17.9%), and tumors of different location in the rest patients. The authors present a review of relevant literature (90 Russian and foreign publications) and 3 clinical observations of BP in the presence of sigmoid and gastric adenocarcinomas and prostatic cancer.

A female patient aged 64 years with Rowells syndrome is described. The patient suffered from systemic lupus erythematosus and erythema exudativum multiforme. The clinical picture of dermatosis was liable to vary throughout a rather short period. Antiherpetic acyclovir therapy proved to be effective.

A single session of photodynamic therapy with intrafocal injection of a Russian photosensitizer radachlorine led to a clinical and cosmetic effect in 6 (66.6%) of 9 patients with atypical solitary keratoacanthomas. This result was signifi cantly higher in comparison with the incidence of spontaneous regression of atypical keratoacanthomas.

The results of therapy of patients with surface and T1N0M0 micronodular basaloma by laser-induced thermotherapy (LITT) and photodynamic therapy with Photolon local photosensitizer are compared. Both methods exhibited similarly high effi ciency. An advantage of LITT is its signifi cantly better tolerance and much better cosmetic results.

Published data on a rather rare genodermatosis - Bloch-Sulzbergers incontinentia pigmenti syndrome - are reviewed and a clinical case is described, observed in three generations.

Published data on the contribution of microorganisms acting as superantigens in atopic dermatitis are reviewed. The functions of Toll-like receptors (TLR) in the skin and the role of TLR2 in stimulation of congenital immunity are discussed. The author shares her experience gained in the use of these drugs in topical therapy for atopic dermatitis: gamma Cu-Zn+ with TLR2-Regul innovation complex (Uriage, France), stimulating the early reactions of congenital immunity in complicated course of dermatitis.

Catelicidine (antibacterial peptide) in the LL-37 form is characterized by anti-infl ammatory, immunoregulatory, and bactericidal effects towards P. acnes. Serum levels of this peptide were measured in 30 patients with acne of different severity (I, II, and III degree) by EIA before and after highly intense blue light (405-420 nm) phototherapy. The level of LL-37 peptide directly correlated with the disease severity and normalized after phototherapy.

The morphology and functions of normal skin of different anatomical appurtenance from representatives of different phototypes have been evaluated. The study was carried out in 30 volunteers aged 20-30 years with skin phototypes I, II and V. VI. The structural parameters of the skin were studied by the optic coherence tomography (OCT) using an optic coherent computer-aided tomography visualizer (Russia) for noninvasive studies of the inner structure of human surface tissues with longitudinal and transverse resolution of 20. The functional characteristics of the skin were evaluated by the Milti Skin Test Center MC 750 (http://nicosmetics.ru). The results were statistically processed by Shapiro-Wilk and Mann-Whitneys tests. The data are presented by medians with the fi rst and third quartiles. Morphological characteristics of normal skin in representatives of different phototypes, associated with certain functional parameters, have been detected. The detected morphofunctional differences were more manifest on the skin sites maximally exposed to ultraviolet irradiation.