<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Current Neurovascular Research</journal-id><journal-title-group><journal-title xml:lang="en">Current Neurovascular Research</journal-title><trans-title-group xml:lang="ru"><trans-title>Current Neurovascular Research</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1567-2026</issn><issn publication-format="electronic">1875-5739</issn><publisher><publisher-name xml:lang="en">Bentham Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">644451</article-id><article-id pub-id-type="doi">10.2174/0115672026316069240502120918</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Medicine</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A Study on the Effects of Different Positions on the Clinical Prognosis of Patients with Acute Ischemic Stroke</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dai</surname><given-names>Qinqin</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Mengmeng</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Yuanli</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Qilan</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Aixia</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Yuming</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Kai</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>, Nursing School of Zhengzhou University</institution></aff><aff id="aff2"><institution>Department of Neurology, The First Affiliated Hospital of Zhengzhou University</institution></aff><pub-date date-type="pub" iso-8601-date="2024-03-01" publication-format="electronic"><day>01</day><month>03</month><year>2024</year></pub-date><volume>21</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>337</fpage><lpage>342</lpage><history><date date-type="received" iso-8601-date="2025-01-07"><day>07</day><month>01</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bentham Science Publishers</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bentham Science Publishers</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/1567-2026/article/view/644451">https://journals.eco-vector.com/1567-2026/article/view/644451</self-uri><abstract xml:lang="en"><p id="idm46041443773920">:The key to treating Acute Ischemic Stroke (AIS) is to rapidly reopen occluded blood vessels, restore blood flow, and rescue the ischemic penumbra. Treatment methods mainly include thrombolysis, endovascular intervention, etc. However, these treatments are limited by strict time windows and technical conditions. Simpler and more feasible methods to improve cerebral blood flow are currently a hot topic in clinical research. In recent years, several studies have shown that changes in body position can effectively improve cerebral blood flow in patients. However, the effect on the neurological functional prognosis of AIS remains inconclusive. This review has examined the effects of changes in body position on the clinical prognosis of AIS, combining relevant guidelines and the latest research. The study has provided evidence of an improvement in the clinical prognosis of AIS.</p></abstract><kwd-group xml:lang="en"><kwd>Position</kwd><kwd>ischemic stroke</kwd><kwd>clinical prognosis</kwd><kwd>cerebral blood flow</kwd><kwd>HDT</kwd><kwd>TLR</kwd><kwd>neurological function.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Qian Y, Ye D, Huang H, et al. Coffee consumption and risk of stroke: A mendelian randomization study. Ann Neurol 2020; 87(4): 525-32. doi: 10.1002/ana.25693 PMID: 32034791</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Fang H, Liu W, Zhang L, et al. A bidirectional mendelian randomization study of selenium levels and ischemic stroke. Front Genet 2022; 13782691 doi: 10.3389/fgene.2022.782691 PMID: 35495125</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Menon BK, Goyal M. Clots, collaterals, and the intracranial arterial tree. Stroke 2016; 47(8): 1972-3. doi: 10.1161/STROKEAHA.116.013829 PMID: 27338927</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Shuaib A, Butcher K, Mohammad AA, Saqqur M, Liebeskind DS. Collateral blood vessels in acute ischaemic stroke: A potential therapeutic target. Lancet Neurol 2011; 10(10): 909-21. doi: 10.1016/S1474-4422(11)70195-8 PMID: 21939900</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Bang OY, Saver JL, Kim SJ, et al. Collateral flow predicts response to endovascular therapy for acute ischemic stroke. Stroke 2011; 42(3): 693-9. doi: 10.1161/STROKEAHA.110.595256 PMID: 21233472</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Azeli Y, Bardají A, Barbería E, et al. Clinical outcomes and safety of passive leg raising in out-of-hospital cardiac arrest: A randomized controlled trial. Crit Care 2021; 25(1): 176. doi: 10.1186/s13054-021-03593-7 PMID: 34034775</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Beretta S, Versace A, Martini B, et al. Head down tilt 15° in experimental intracerebral hemorrhage: A randomized noninferiority safety trial. Eur J Neurol 2021; 28(2): 525-31. doi: 10.1111/ene.14560 PMID: 32986293</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ginsberg M D. The cerebral collateral circulation: Relevance to pathophysiology and treatment of stroke. Neuropharmacology 2018; 134(Pt B): 280-92.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lin E, Kamel H, Gupta A. RoyChoudhury A, Girgis P, Glodzik L. Incomplete circle of Willis variants and stroke outcome. Eur J Radiol 2022; 153110383 doi: 10.1016/j.ejrad.2022.110383 PMID: 35661459</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Ginsberg MD. Expanding the concept of neuroprotection for acute ischemic stroke: The pivotal roles of reperfusion and the collateral circulation. Prog Neurobiol 2016; 145-146: 46-77. doi: 10.1016/j.pneurobio.2016.09.002 PMID: 27637159</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Ishibashi S, Iwasawa E, Ichijo M, Yokota T. Acute development of collateral circulation and therapeutic prospects in ischemic stroke. Neural Regen Res 2016; 11(3): 368-71. doi: 10.4103/1673-5374.179033 PMID: 27127459</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Han M, Kwon I, Ha J, et al. Collateral augmentation treatment with a combination of acetazolamide and head-down tilt in a rat ischemic stroke model. J Clin Neurosci 2020; 73: 252-8. doi: 10.1016/j.jocn.2020.01.079 PMID: 32037062</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Zhao ZA, Zhang NN, Cui Y, Chen HS. The effect of head‐down tilt in experimental acute ischemic stroke. Eur J Neurol 2023; 30(1): 155-61. doi: 10.1111/ene.15597 PMID: 36256506</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Benarroch EE. The arterial baroreflex. Neurology 2008; 71(21): 1733-8. doi: 10.1212/01.wnl.0000335246.93495.92 PMID: 19015490</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Nasr N, Czosnyka M, Pavy-Le Traon A, et al. Baroreflex and cerebral autoregulation are inversely correlated. Circ J 2014; 78(10): 2460-7. doi: 10.1253/circj.CJ-14-0445 PMID: 25187067</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Claassen JAHR, Meel-van den Abeelen ASS, Simpson DM, Panerai RB. Transfer function analysis of dynamic cerebral autoregulation: A white paper from the international cerebral autoregulation research network. J Cereb Blood Flow Metab 2016; 36(4): 665-80. doi: 10.1177/0271678X15626425 PMID: 26782760</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Dilenge D, Perey B. An angiographic study of the meningorachidian venous system. Radiology 1973; 108(2): 333-7. doi: 10.1148/108.2.333 PMID: 4198121</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Ciuti G, Righi D, Forzoni L, Fabbri A, Pignone AM. Differences between internal jugular vein and vertebral vein flow examined in real time with the use of multigate ultrasound color Doppler. AJNR Am J Neuroradiol 2013; 34(10): 2000-4. doi: 10.3174/ajnr.A3557 PMID: 23721896</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Doepp F, Schreiber SJ, von Münster T, Rademacher J, Klingebiel R, Valdueza JM. How does the blood leave the brain? A systematic ultrasound analysis of cerebral venous drainage patterns. Neuroradiology 2004; 46(7): 565-70. doi: 10.1007/s00234-004-1213-3 PMID: 15258709</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Qvarlander S, Sundström N, Malm J. Postural effects on intracranial pressure: Modeling and clinical evaluation. J Appl Physiol 2013; 115(10): 1474-80.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Sagirov AF, Sergeev TV, Shabrov AV, Yurov AY, Guseva NL, Agapova EA. Postural influence on intracranial fluid dynamics: An overview. J Physiol Anthropol 2023; 42(1): 5. doi: 10.1186/s40101-023-00323-6 PMID: 37055862</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Wojner-Alexander AW, Garami Z, Chernyshev OY, Alexandrov AV. Heads down. Neurology 2005; 64(8): 1354-7. doi: 10.1212/01.WNL.0000158284.41705.A5 PMID: 15851722</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. Lancet 2014; 384(9958): 1929-35. doi: 10.1016/S0140-6736(14)60584-5 PMID: 25106063</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Alexandrov AW, Tsivgoulis G, Hill MD, et al. Headpost. Neurology 2018; 90(19): 885-9. doi: 10.1212/WNL.0000000000005481 PMID: 29643083</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Mariani J, Beretta S, Diamanti S, et al. Head down tilt 15° in acute ischemic stroke with poor collaterals: A randomized preclinical trial. Neuroscience 2023; 523: 1-6. doi: 10.1016/j.neuroscience.2023.05.011 PMID: 37211082</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Gauthier A, Gérardin P, Renou P, et al. Trendelenburg positioning in large vessel ischaemic stroke: A pre-post observational study using propensity score matching. Cerebrovasc Dis 2018; 46(1-2): 24-32. doi: 10.1159/000490423 PMID: 30056454</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Chen HS, Zhang NN, Cui Y, et al. A randomized trial of Trendelenburg position for acute moderate ischemic stroke. Nat Commun 2023; 14(1): 2592. doi: 10.1038/s41467-023-38313-y PMID: 37147320</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Beretta S, Versace A, Carone D, et al. Cerebral collateral therapeutics in acute ischemic stroke: A randomized preclinical trial of four modulation strategies. J Cereb Blood Flow Metab 2017; 37(10): 3344-54. doi: 10.1177/0271678X16688705 PMID: 28112023</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Monnet X, Rienzo M, Osman D, et al. Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med 2006; 34(5): 1402-7. doi: 10.1097/01.CCM.0000215453.11735.06 PMID: 16540963</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Reuter DA, Kirchner A, Felbinger TW, et al. Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function. Crit Care Med 2003; 31(5): 1399-404. doi: 10.1097/01.CCM.0000059442.37548.E1 PMID: 12771609</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Ryu HH, Moore JC, Yannopoulos D, et al. The effect of head up cardiopulmonary resuscitation on cerebral and systemic hemodynamics. Resuscitation 2016; 102: 29-34. doi: 10.1016/j.resuscitation.2016.01.033 PMID: 26905388</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Holmén J, Herlitz J, Jimenez-Herrera M, Karlsson T, Axelsson C. Passive leg raising in out-of-hospital cardiac arrest. Resuscitation 2019; 137: 94-101. doi: 10.1016/j.resuscitation.2019.02.017 PMID: 30790693</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Anderson CS, Arima H, Lavados P, et al. Cluster-randomized, crossover trial of head positioning in acute stroke. N Engl J Med 2017; 376(25): 2437-47. doi: 10.1056/NEJMoa1615715 PMID: 28636854</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Dragoumanos V, Iacovidou N, Chalkias A, et al. Passive leg raising during cardiopulmonary resuscitation results in improved neurological outcome in a swine model of prolonged ventricular fibrillation. Am J Emerg Med 2012; 30(9): 1935-42. doi: 10.1016/j.ajem.2012.04.014 PMID: 22795422</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Zhang Y, Jiménez-Herrera M, Axelsson C, Cheng Y. Not bad: Passive leg raising in cardiopulmonary resuscitation-a new modeling study. Front Physiol 2017; 7: 665. doi: 10.3389/fphys.2016.00665 PMID: 28119619</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Shin DA, Park J, Lee JC, Shin SD, Kim HC. Computational simulation of passive leg-raising effects on hemodynamics during cardiopulmonary resuscitation. Comput Methods Programs Biomed 2017; 140: 195-200. doi: 10.1016/j.cmpb.2016.12.011 PMID: 28254076</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Lorensini S, Prakash S, McNeill D, Spencer N, Bihari S. A pilot study to examine the effect of passive straight leg raise performed during cardiopulmonary resuscitation on cerebral perfusion measured by noninvasive cerebral oximetry. Crit Care Explor 2023; 5(4)e0880 doi: 10.1097/CCE.0000000000000880 PMID: 36998526</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Monnet X, Teboul JL. Passive leg raising: Five rules, not a drop of fluid! Crit Care 2015; 19(1): 18. doi: 10.1186/s13054-014-0708-5 PMID: 25658678</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Bauer M, Basic D, Riedmann M, et al. Passive leg raising in brain injury patients within the neurointensive care unit. A prospective trial. Anaesthesiol Intensive Ther 2021; 53(3): 200-6. doi: 10.5114/ait.2021.108361 PMID: 35164482</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Paelinck B, van Eck JW, De Hert SG, Gillebert TC. Effects of postural changes on cardiac function in healthy subjects. Eur J Echocardiogr 2003; 4(3): 196-201. doi: 10.1016/S1525-2167(02)00167-1 PMID: 12928023</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Gillebert TC. Leg lifting in HFrEF, Frank-starling, and mitral regurgitation. JACC Cardiovasc Imaging 2017; 10(6): 619-21. doi: 10.1016/j.jcmg.2016.08.006 PMID: 27865724</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Thiel SW, Kollef MH, Isakow W. Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: An observational cohort study. Crit Care 2009; 13(4): R111. doi: 10.1186/cc7955 PMID: 19586543</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Préau S, Saulnier F, Dewavrin F, Durocher A, Chagnon JL. Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis. Crit Care Med 2010; 38(3): 819-25. doi: 10.1097/CCM.0b013e3181c8fe7a PMID: 20016380</mixed-citation></ref></ref-list></back></article>
