Morphometric Analysis of Corpus Callosum in Individuals with Alzheimer's Disease: Magnetic Resonance Imaging (MRI) Study


Дәйексөз келтіру

Толық мәтін

Аннотация

Introduction:The Corpus Callosum (CC) is the largest commissural tract in the nervous system. Few studies have examined the extent of CC in Alzheimer's disease (AD) patients, and these studies have reported conflicting findings.

Materials and Methods:The study was performed using 176 brain MRI images of 88 Alzheimer's patients (55 women-32 men) and 88 healthy individuals (44 women-44 men).

Results:In our study, 7 different parameters of the CC were measured, and their average values were determined. We measured each parameter separately in AD patients and healthy individuals and compared them with each other.

Conclusion:CC has an important place not only in Patients with AD but also in other neurodegenerative diseases. We consider that our study will be useful in the evaluation of Patients with AD.

Авторлар туралы

Musa Acar

Department of Physiotherapy and Rehabilitation, Faculty of Nezahat Keleşoğlu Health Sciences, Necmettin Erbakan University

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Sultan Uğur

Department of Radiology, Pursaklar State Hospital

Email: info@benthamscience.net

Әдебиет тізімі

  1. Zhu M, Wang X, Gao W, et al. Corpus callosum atrophy and cognitive decline in early Alzheimer’s disease: longitudinal MRI study. Dement Geriatr Cogn Disord 2014; 37(3-4): 214-22. doi: 10.1159/000350410 PMID: 24193144
  2. Zeng F, Li Y, Xu Y, et al. Strategies targeting soluble β-amyloid oligomers and their application to early diagnosis of Alzheimer’s disease. Curr Alzheimer Res 2020; 16(12): 1132-42. doi: 10.2174/1567205016666191031163504 PMID: 31670622
  3. Bolós M, Perea JR, Avila J. Alzheimer’s disease as an inflammatory disease. Biomol Concepts 2017; 8(1): 37-43. doi: 10.1515/bmc-2016-0029 PMID: 28231054
  4. Lane CA, Hardy J, Schott JM. Alzheimer’s disease. Eur J Neurol 2018; 25(1): 59-70. doi: 10.1111/ene.13439 PMID: 28872215
  5. Guo X, Wang Z, Li K, et al. Voxel-based assessment of gray and white matter volumes in Alzheimer’s disease. Neurosci Lett 2010; 468(2): 146-50. doi: 10.1016/j.neulet.2009.10.086 PMID: 19879920
  6. Eser O, Haktanır A, Boyacı MG, Doğan FA, Karavelioğlu E. Korpus kallozumun morfometrik ölçümleri. Türk Nöroşirürji Dergisi 2011; 21(1): 14-7.
  7. Khasawneh RR, Abu-El-Rub E, Alzu’bi A, Abdelhady GT, Al-Soudi HS. Corpus callosum anatomical changes in Alzheimer patients and the effect of acetylcholinesterase inhibitors on corpus callosum morphometry. PLoS One 2022; 17(7): e0269082. doi: 10.1371/journal.pone.0269082 PMID: 35895623
  8. Patra A, Singla R, Chaudhary P, Malhotra V. Morphometric analysis of the corpus callosum using cadaveric brain: An anatomical study. Asian J Neurosurg 2020; 15(2): 322-7. doi: 10.4103/ajns.AJNS_328_19 PMID: 32656126
  9. Al-Hadidi M T, Kalbouneh H M, Ramzy A, Al Sharei A, Badran D H, Shatarat A. Gender and age-related differences in the morphometry of corpus callosum: MRI study. Eur J Anat 2021; 25(1): 15-24.
  10. Kara F, Höfling C, Roßner S, et al. In vivo longitudinal monitoring of changes in the corpus callosum integrity during disease progression in a mouse model of Alzheimer’s disease. Curr Alzheimer Res 2015; 12(10): 941-50. doi: 10.2174/1567205012666151027123728 PMID: 26502821
  11. Poleneni SR, Jakka LD, Chandrupatla M, Vinodini L, Ariyanachi K. Morphometry of corpus callosum in south indian population. Ann Neurosci 2021; 28(3-4): 150-5. doi: 10.1177/09727531211059892 PMID: 35341238
  12. Kumar S, De Luca A, Leemans A, et al. Topology of diffusion changes in corpus callosum in Alzheimer’s disease: An exploratory case-control study. Front Neurol 2022; 13: 1005406. doi: 10.3389/fneur.2022.1005406 PMID: 36530616
  13. Zhu M, Gao W, Wang X, Shi C, Lin Z. Progression of corpus callosum atrophy in early stage of Alzheimer’s disease: MRI based study. Acad Radiol 2012; 19(5): 512-7. doi: 10.1016/j.acra.2012.01.006 PMID: 22342652
  14. Kamal S, Park I, Kim YJ, Kim YJ, Lee U. Alteration of the corpus callosum in patients with Alzheimer’s disease: Deep learning-based assessment. PLoS One 2021; 16(12): e0259051. doi: 10.1371/journal.pone.0259051 PMID: 34941878
  15. Hensel A, Wolf H, Kruggel F, et al. Morphometry of the corpus callosum in patients with questionable and mild dementia. J Neurol Neurosurg Psychiatry 2002; 73(1): 59-61. doi: 10.1136/jnnp.73.1.59 PMID: 12082047
  16. Frederiksen KS, Garde E, Skimminge A, et al. Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study. Dement Geriatr Cogn Disord 2011; 32(4): 279-86. doi: 10.1159/000334949 PMID: 22262017
  17. Herron TJ, Kang X, Woods DL. Automated measurement of the human corpus callosum using MRI. Front Neuroinform 2012; 6: 25. doi: 10.3389/fninf.2012.00025 PMID: 22988433
  18. Piras F, Vecchio D, Kurth F, et al. Corpus callosum morphology in major mental disorders: a magnetic resonance imaging study. Brain Commun 2021; 3(2): fcab100. doi: 10.1093/braincomms/fcab100 PMID: 34095833
  19. Reddy BS, Naik D, Sakalecha AK, Uhasai K, Mannan J. Role of magnetic resonance imaging in morphometric alterations of corpus callosum in stroke patients. Cureus 2023; 15(2)
  20. Walterfang M, Luders E, Looi JCL, et al. Shape analysis of the corpus callosum in Alzheimer’s disease and frontotemporal lobar degeneration subtypes. J Alzheimers Dis 2014; 40(4): 897-906. doi: 10.3233/JAD-131853 PMID: 24531157
  21. Tomimoto H, Lin JX, Matsuo A, et al. Different mechanisms of corpus callosum atrophy in Alzheimer's disease and vascular dementia. J Neurol 2004; 251(4): 398-406. doi: 10.1007/s00415-004-0330-6 PMID: 15083283
  22. Tripathi PN, Srivastava P, Sharma P, et al. Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory. Bioorg Chem 2019; 85: 82-96. doi: 10.1016/j.bioorg.2018.12.017 PMID: 30605887
  23. Tripathi PN, Lodhi A, Rai SN, Nandi NK, Dumoga S, Yadav P. Review of pharmacotherapeutic targets in Alzheimer’s Disease and its management using traditional medicinal plants. Degenerat Neurolog Neuromuscul Dis 2024; 2024: 47-74.

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