Current Pediatric ReviewsCurrent Pediatric ReviewsCurrent Pediatric Reviews1573-39631875-6336Bentham Science64542810.2174/1573396318666220827103731MedicineResearch ArticleInterventions for Enuresis in Children and Adolescents: An Overview of Systematic ReviewsCorreia MorettiEduardainfo@benthamscience.netda SilvaIvson Bezerrainfo@benthamscience.netBoaviagemAlessandrainfo@benthamscience.netde LimaAnna Myrnainfo@benthamscience.netLemosAndreainfo@benthamscience.netDepartment of Anatomy, Federal University of Pernambuco, Child and Adolescent Health,, Federal University of Per-nambuco -Department of Morphology, Federal University of ParaibaDepartment of Physiotherapy, Federal University of PernambucoDepartment of Animal Morphology and Physiology, Federal Rural University of PernambucoDepartment of Physical Therapy, Federal University of Pernambuco01012024201768811012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1573-3963/article/view/645428

Background:enuresis is an involuntary and intermittent loss of urine during sleep and its treatment can be done by pharmacological and non-pharmacological strategies.

Objective:to conduct an overview to carry out a survey of the systematic reviews about treatment options for children/adolescents with enuresis.

Methods:Databases used were Cochrane Library, PROSPERO, MEDLINE/PubMed, EMBASE, LILACS/BVS, PEDro, SciELO and Google Scholar. Any type of intervention for the treatment of enuresis in children/adolescents were selected by two independent researchers. Data extraction was done by two independent researchers. The risk of bias was assessed using Risk of Bias in Systematic Reviews (ROBIS) and A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2).

Results:seven systematic reviews were included. According to ROBIS, three reviews had a low risk of bias, while the others had a high risk of bias. Based on AMSTAR-2, four systematic reviews were of moderate quality, two were low quality and one was critically low quality.

Conclusion:there is moderate confidence that the use of desmopressin plus an anticholinergic agent increases the chance of complete response compared to desmopressin alone. Neurostimulation may increase the risk of responses ≥50% and ≥90% compared to the control group. Likewise, it appears that electrical stimulation is superior to placebo about the chance of response ≥50%. In addition, there is the clinical relevance in reducing enuresis episodes per week when neurostimulation is used compared to control groups.

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