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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Current Pediatric Reviews</journal-id><journal-title-group><journal-title xml:lang="en">Current Pediatric Reviews</journal-title><trans-title-group xml:lang="ru"><trans-title>Current Pediatric Reviews</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1573-3963</issn><issn publication-format="electronic">1875-6336</issn><publisher><publisher-name xml:lang="en">Bentham Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">645710</article-id><article-id pub-id-type="doi">10.2174/1573396320666230913103007</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Medicine</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Reactive Arthritis in Children: Case Report, Narrative Review and Proposed Therapy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alshaya</surname><given-names>Milad</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Almutairi</surname><given-names>Nouf</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Alrasheed</surname><given-names>Abdulrahman</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Albanaqi</surname><given-names>Ihtifal</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Laxer</surname><given-names>Ronald</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name><surname>Alhammad</surname><given-names>Abdullah</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff id="aff1"><institution>Pediatric Department, King Abdullah Specialized Children Hospital, King Abdulaziz Medical City, Ministry of National Guard Health Affairs</institution></aff><aff id="aff2"><institution>Pediatric Department, King Fahad Medical City</institution></aff><aff id="aff3"><institution>Division of Rheumatology, Rheumatology Department, The Hospital for Sick Children, Departments of Pediatrics and Medicine, University of Toronto</institution></aff><aff id="aff4"><institution>Department of Medical Imaging, King Abdullah Specialized Children Hospital, King Abdulaziz Medical City, Ministry of National Guard Health Affairs</institution></aff><pub-date date-type="pub" iso-8601-date="2024-04-01" publication-format="electronic"><day>01</day><month>04</month><year>2024</year></pub-date><volume>20</volume><issue>4</issue><issue-title xml:lang="ru"/><fpage>444</fpage><lpage>452</lpage><history><date date-type="received" iso-8601-date="2025-01-11"><day>11</day><month>01</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bentham Science Publishers</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bentham Science Publishers</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/1573-3963/article/view/645710">https://journals.eco-vector.com/1573-3963/article/view/645710</self-uri><abstract xml:lang="en"><p id="idm46466589635984">Reactive arthritis is an acute inflammatory aseptic arthritis that is preceded by an infectious process in genetically predisposed individuals. It has been associated with gastrointestinal or genitourinary infection. Reactive arthritis is rare in children. In this review, we present two index cases that need biologic treatment followed by a thorough review of reactive arthritis in children and adolescents with proposed treatment algorithm.</p></abstract><kwd-group xml:lang="en"><kwd>Arthritis</kwd><kwd>HLA B27</kwd><kwd>juvenile</kwd><kwd>ReA</kwd><kwd>reactive</kwd><kwd>sacroiliitis.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Junghanns O. Another case of urethritis non gonorrhoica and septic general disease: A contribution to spirochaetosis arthritica. Dtsch Med Wochenschr 1918; 44: 1304-5. doi: 10.1055/s-0028-1134810</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Flores D, Marquez J, Garza M, Espinoza LR. Reactive arthritis: Newer developments. 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