Mesenchymal Stem Cell-derived Type II Alveolar Epithelial Progenitor Cells Attenuate LPS-induced Acute Lung Injury and Reduce P63 Expression
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| 1. | Title | Title of document | Mesenchymal Stem Cell-derived Type II Alveolar Epithelial Progenitor Cells Attenuate LPS-induced Acute Lung Injury and Reduce P63 Expression |
| 2. | Creator | Author's name, affiliation, country | Ning Ma; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Mengwei Zhang; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Guofeng Xu; Inflammation & Allergic Diseases Research Uni, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Lifang Zhang; Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Min Luo; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Meihua Luo; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Xing Wang; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Hongmei Tang; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Xiaoyun Wang; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Li Liu; Laboratory of Anesthesiology, Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Xiaolin Zhong; Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Jianguo Feng; Laboratory of Anesthesiology, Southwest Medical University |
| 2. | Creator | Author's name, affiliation, country | Yuying Li; Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Acute lung injury; LPS; mesenchymal stem cells; type II alveolar epithelial progenitor cells; P63; BM-MSCAECIIs. |
| 4. | Description | Abstract | Aim:Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical respiratory-failure disease mainly characterized by acute damage to the alveolar epithelium and pulmonary vascular endothelial cells. Stem cell therapy has emerged as a potential regenerative strategy for ARDS/ALI, however, the outcome is limited, and the underlying mechanisms are unclear. Introduction:We established a differentiation system for bone marrow-derived mesenchymal stem cellderived (BM-MSC) type II alveolar epithelial progenitor cells (AECIIs) and assessed their regulatory effects on lipopolysaccharide (LPS)-induced ALI. Methods:We induced BM-MSC differentiation into AECIIs using a specific conditioned medium. After 26 days of differentiation, 3×105 BM-MSC-AECIIs were used to treat mice with LPS-induced ALI through tracheal injection. Results:After tracheal injection, BM-MSC-AECIIs migrated to the perialveolar area and reduced LPSinduced lung inflammation and pathological injury. RNA-seq suggested that P63 protein was involved in the effects of BM-MSC-AECIIs on lung inflammation. Conclusion:Our results suggest that BM-MSC-AECIIs may reduce LPS-induced acute lung injury by decreasing P63 expression. |
| 5. | Publisher | Organizing agency, location | Bentham Science |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 01.01.2024 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://journals.eco-vector.com/1574-888X/article/view/645716 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.2174/1574888X18666230501234836 |
| 11. | Source | Title; vol., no. (year) | Current Stem Cell Research & Therapy; Vol 19, No 2 (2024) |
| 12. | Language | English=en | |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
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