<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Psychopharmacology and Addiction Biology</journal-id><journal-title-group><journal-title xml:lang="en">Psychopharmacology and Addiction Biology</journal-title><trans-title-group xml:lang="ru"><trans-title>Психофармакология и биологическая наркология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1606-8181</issn><issn publication-format="electronic">2070-5670</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">694103</article-id><article-id pub-id-type="doi">10.17816/phbn694103</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Potential for using an artificial intelligence-based predictive model to identify risk groups for developing alcohol delirium in patients with alcohol withdrawal syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности применения прогностической модели на основе искусственного интеллекта с целью выявления группы риска развития алкогольного делирия у пациентов с синдромом отмены алкоголя</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7867-1830</contrib-id><name-alternatives><name xml:lang="en"><surname>Utkin</surname><given-names>Sergei</given-names></name><name xml:lang="ru"><surname>Уткин</surname><given-names>Сергей Ионович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ph.D., Leading Researcher, Science Department</p></bio><bio xml:lang="ru"><p>к.м.н., ведущий научный сотрудник, отдел наука</p></bio><email>srgka@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7877-0632</contrib-id><contrib-id contrib-id-type="spin">5027-8116</contrib-id><name-alternatives><name xml:lang="en"><surname>Derevlev</surname><given-names>Maksim</given-names></name><name xml:lang="ru"><surname>Деревлев</surname><given-names>Максим</given-names></name></name-alternatives><bio xml:lang="en"><p>Junior Research Fellow, science</p></bio><bio xml:lang="ru"><p>младший научный сотрудник, наука</p></bio><email>DerevlevMN@zdrav.mos.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9614-7343</contrib-id><contrib-id contrib-id-type="spin">8427-5025</contrib-id><name-alternatives><name xml:lang="en"><surname>Masyakin</surname><given-names>Anton V.</given-names></name><name xml:lang="ru"><surname>Масякин</surname><given-names>Антон Валерьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences; Director</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, директор</p></bio><email>mnpcn@zdrav.mos.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1200-5434</contrib-id><contrib-id contrib-id-type="spin">1281-8068</contrib-id><name-alternatives><name xml:lang="en"><surname>Kharitonenkova</surname><given-names>Evgeniia Y.</given-names></name><name xml:lang="ru"><surname>Харитоненкова</surname><given-names>Евгения Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med); deputy Chief Physician</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, зам. гл. врача</p></bio><email>evgenia4958@mail.ru</email><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow Research and Practical Centre for Narcology,Moscow, Russia</institution></aff><aff><institution xml:lang="ru">МОСКОВСКИЙ НАУЧНО-ПРАКТИЧЕСКИЙ ЦЕНТР НАРКОЛОГИИ&#13;
Государственное бюджетное учреждение здравоохранения г.Москвы</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov University, Moscow, Russia</institution></aff><aff><institution xml:lang="ru">Институт клинической медицины им. Н.В. Склифосовского Сеченовского университета, Москва, Россия.</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБУЗ Московский научно-практический центр наркологии ДЗМ</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">GBUZ "Moscow Scientific and Practical Center for Narcology DZM"</institution></aff><aff><institution xml:lang="ru">ГБУЗ "Московский научно-практический центр наркологии ДЗМ"</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">GBUZ "Moscow Scientific and Practical Center for Narcology DZM"</institution></aff><aff><institution xml:lang="ru">ГБУЗ Московский научно-практический центр наркологии ДЗМ</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-02-06" publication-format="electronic"><day>06</day><month>02</month><year>2026</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="ru"/><history><date date-type="received" iso-8601-date="2025-10-23"><day>23</day><month>10</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-12-24"><day>24</day><month>12</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; , Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; , Эко-Вектор</copyright-statement><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1606-8181/article/view/694103">https://journals.eco-vector.com/1606-8181/article/view/694103</self-uri><abstract xml:lang="en"><p><italic>The aim of the study: to develop a method for predicting the development of alcohol delirium in patients with initial manifestations of alcohol withdrawal syndrome.</italic></p> <p><italic>Materials and methods: 4 laboratory indicators were used to build prognostic models: the number of platelets in the blood of patients, levels of potassium, sodium and chlorine in the blood serum. The probabilistic model is based on the multilayer perceptron (MLP) algorithm, binary on the random forest (Random Forest, RF) algorithm. To train the models, an anonymized database of patients with alcohol withdrawal syndrome (498 people) was used, 295 patients from this sample had alcohol delirium, and 203 had uncomplicated withdrawal syndrome.</italic></p> <p><italic>Study results: Both models on the test sample showed good results: the average value of the forecast accuracy of the model based on the MLP algorithm - 84%, on RF - 83%. The MLP model was verified in an addiction hospital setting, with 84.4% accuracy of correct predictions</italic></p></abstract><trans-abstract xml:lang="ru"><p><italic>Цель исследования: разработать метод прогнозирования развития алкогольных делириев у пациентов с начальными проявлениями синдрома отмены алкоголя.</italic></p> <p><italic>Материалы и методы: для построения прогностических моделей использованы 4 лабораторных показателя: количество тромбоцитов в крови пациентов, уровни калия, натрия и хлора в сыворотке крови. Вероятностная модель основана на алгоритме многослойного перцептрона (</italic><italic>MLP</italic><italic>), бинарная на алгоритме случайного леса (</italic><italic>Random</italic><italic> </italic><italic>Forest</italic><italic>, </italic><italic>RF</italic><italic>).</italic> <italic>Для обучения моделей была использована анонимизированная база данных пациентов с синдромом отмены алкоголя (498 человек), у 295 пациентов из данной выборки наблюдался алкогольный делирий, а у 203 – неосложненный синдром отмены.</italic></p> <p><italic>Результаты исследования: Обе модели на тестовой выборке показали хорошие результаты: среднее значение точности прогноза модели, основанной на алгоритме </italic><italic>MLP</italic><italic> – 84%, на </italic><italic>RF</italic><italic> – 83 %. </italic><italic>MLP</italic><italic> модель была верифицирована в условиях наркологического стационара, точность верных прогнозов составила 84,4%.</italic></p></trans-abstract><kwd-group xml:lang="en"><kwd>alcoholic delirium, delirium tremens, alcohol withdrawal syndrome, artificial neural network, prognostic model</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>алкогольный делирий, синдром отмены алкоголя, искусственная нейронная сеть, прогностическая модель</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Schuckit MA, Tipp JE, Reich T, Hesselbrock VM, Bucholz KK. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction. 1995;90(10):1335–1347. doi: 10.1046/j.1360-0443.1995.901013355.x</mixed-citation><mixed-citation xml:lang="ru">Schuckit M.A., Tipp J.E., Reich T., et al. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. // Addiction. 1995. Vol. 90, No 10. P. 1335–1347. doi: 10.1046/j.1360-0443.1995.901013355.x</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Utkin SI. Alcohol withdrawal delirium (delirium tremens): guidebook for doctors. Moscow: GEOTAR-Media; 2025. 104 p. doi: 10.33029/9704-9197-3-AWS-2025-1-104. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Уткин С. И. Синдром отмены алкоголя с делирием (белая горячка): руководство для врачей. Москва: Общество с ограниченной ответственностью Издательская группа "ГЭОТАР-Медиа", 2025. 104 с. – ISBN 978-5-9704-9197-3. Doi: 10.33029/9704-9197-3-AWS-2025-1-104. – EDN UKYPRM</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Mainerova B, Prasko J, Latalova K, Axmann K, Cerna M, Horacek R, et al. Alcohol withdrawal delirium: diagnosis, course and treatment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(1):44–52. doi: 10.5507/bp.2013.089</mixed-citation><mixed-citation xml:lang="ru">Mainerova B., Prasko J., Latalova K. et al. Alcohol withdrawal delirium: diagnosis, course and treatment. // Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015. Vol. 159, No 1. P. 44–52. doi: 10.5507/bp.2013.089</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Beriozkin AS, Govorin NV, Simbirtsev АА. Kognitivniy deficit u bolnyh, perenesshyh alcogolniy deliriy. Rossiyskiy psihiatricheskiy zhurnal. 2018; 5: 45-50. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Березкин А. С., Говорин Н. В., Симбирцев А. А. Когнитивный дефицит у больных, перенёсших алкогольный делирий // Российский психиатрический журнал. 2018. № 5. С. 45-50. – EDN YMBRLF.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Day E, Daly C. Clinical management of the alcohol withdrawal syndrome. Addiction. 2022 Mar;117(3):804-814. doi: 10.1111/add.15647</mixed-citation><mixed-citation xml:lang="ru">Day E., Daly C. Clinical management of the alcohol withdrawal syndrome. // Addiction. 2022. Vol. 117, No 3. P. 804-814. doi: 10.1111/add.15647</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Maldonado JR. Novel Algorithms for the Prophylaxis and Management of Alcohol Withdrawal Syndromes-Beyond Benzodiazepines. Crit Care Clin. 2017;33(3):559-599. doi: 10.1016/j.ccc.2017.03.012</mixed-citation><mixed-citation xml:lang="ru">Maldonado JR. Novel Algorithms for the Prophylaxis and Management of Alcohol Withdrawal Syndromes-Beyond Benzodiazepines.// Crit Care Clin. 2017. Vol. 33, No 3. P. 559-599. doi: 10.1016/j.ccc.2017.03.012</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Palmstierna T. A model for predicting alcohol withdrawal delirium. Psychiatr Serv. 2001; 52(6): 820–823. doi: 10.1176/appi.ps.52.6.820</mixed-citation><mixed-citation xml:lang="ru">Palmstierna T. A model for predicting alcohol withdrawal delirium. // Psychiatr Serv. 2001. Vol. 52, No 6. P. 820–823. doi: 10.1176/appi.ps.52.6.820</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. Prescrire Int. 2007 Feb;16(87):24-31</mixed-citation><mixed-citation xml:lang="ru">Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. // Prescrire Int. 2007. Vol.16, No 87. P. 24-31</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014;38(10):2664-77. doi: 10.1111/acer.12529</mixed-citation><mixed-citation xml:lang="ru">Goodson C.M., Clark B.J., Douglas I.S. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. // Alcohol Clin Exp Res. 2014. Vol. 38, No 10. P. 2664-2677. doi: 10.1111/acer.12529</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Lee JH, Jang MK, Lee JY, Kim SM, Kim KH, Park JY, Lee JH, Kim HY, Yoo JY. Clinical predictors for delirium tremens in alcohol dependence. J Gastroenterol Hepatol. 2005; 20(12):1833-7</mixed-citation><mixed-citation xml:lang="ru">Lee J.H., Jang M.K., Lee J.Y., et. al. Clinical predictors for delirium tremens in alcohol dependence. // J Gastroenterol Hepatol. 2005. Vol. 20, No. 12. P. 1833-1937. doi: 10.1111/j.1440-1746.2005.03932.x.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Lee JS, Lee BH, Ji H, Jang GH, Shin HE. Clinical Factors Correlated to Delirium Tremens during Acute Alcohol Withdrawal of Inpatients with Alcohol Dependence. J Korean Neuropsychiatr Assoc. 2012;51(4):164-169. doi: 10.4306/jknpa.2012.51.4.164</mixed-citation><mixed-citation xml:lang="ru">Lee J.S., Lee B.H., Ji H. et al. Clinical Factors Correlated to Delirium Tremens during Acute Alcohol Withdrawal of Inpatients with Alcohol Dependence. // J Korean Neuropsychiatr Assoc. 2012. Vol. 51, No 4. P. 164-169. doi: 10.4306/jknpa.2012.51.4.164</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Utkin SI, Buzik OZh, Dyuzhev DV. Objective predictors for delirium tremens based on physiological and metabolic indicators Voprosy narkologii [Journal of addiction problems]. 2021;12(207):17-30. doi: 10.47877/0234-0623_2021_12_17. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Уткин, С. И., Бузик О. Ж., Дюжев Д. В. Объективные предикторы развития алкогольного делирия на основе физиологических и метаболических показателей // Вопросы наркологии. 2021. T. 12, № 207. С. 17-30. doi: 10.47877/0234-0623_2021_12_17</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Bikku T. Multi-layered deep learning perceptron approach for health risk prediction. J Big Data 7, 50 (2020). doi: 10.1186/s40537-020-00316-7</mixed-citation><mixed-citation xml:lang="ru">Bikku T. Multi-layered deep learning perceptron approach for health risk prediction. // J Big Data. 2020. Vol. 7, No 50. doi: 10.1186/s40537-020-00316-7</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Utkin SI, Zaitsev IА. Prevalence of various forms of alcohol withdrawal syndrome in Moscow, Russia. Voprosy narkologii [Journal of addiction problems]. 2024;36(2):98–116. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Уткин, С. И., Зайцев И. А. Распространенность различных форм синдрома отмены алкоголя в Г. Москве // Вопросы наркологии. 2024. Т. 36, № 2. – С. 98-116.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
