Russian Journal of Physiotherapy, Balneology and RehabilitationRussian Journal of Physiotherapy, Balneology and Rehabilitation1681-34562413-2969Eco-Vector5795810.17816/1681-3456-2020-19-3-1Research ArticlePhotodynamic therapy for correction of involutive facial skin changesSurkichinS. I.<p>PhD</p>info@eco-vector.comhttps://orcid.org/0000-0003-0521-0333BochkovaN. V.info@eco-vector.comhttps://orcid.org/0000-0001-6457-7130KholupovaL. S.karsekals@gmail.comhttps://orcid.org/0000-0002-2781-4587Central State Medical Academy of the Administrative Department of the President of Russia150620201931401441001202110012021Copyright © 2020, Eco-Vector2020<p><strong><em>Background.</em></strong><em>The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy.</em></p>
<p><strong><em>Objective:</em></strong><em>the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure.</em></p>
<p><strong><em>Methods.</em></strong><em>The study involved patients aged 4060 years with signs of involutive changes in the skin of the face. In group 1 (n=36), patients underwent therapy using only light coherent radiation. In group 2 (n=35), patients underwent PDT using light coherent radiation.</em></p>
<p><strong><em>Results.</em></strong><em>According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group2, more positive indicators were obtained than in group1. When assessing safety, the results in groups 1 and2 are comparable.</em></p>
<p><strong><em>Conclusions.</em></strong><em>The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.</em></p>photodynamic therapyphototherapyphotoaginginvolutionchlorin E6photosensitizerфотодинамическая терапияфототерапияфотостарениеинволюцияхлорин Е6фотосенсибилизатор[Kim M, Park HJ. Molecular mechanisms of skin aging and rejuvenation. Licensee IntechOpen; 2016. doi: 10.5772/62983.][Alenichev AYu, Kruglova LS, Fedorov SM, et al. Combined application of microneedle RF-therapy and injections by platelet-rich plasma activated by autological thrombin in aesthetic medicine. Russian Journal of the Physial Therapy, Balneotherapy and Rehabilitation. 2017;16(6):320-324. (In Russ). doi: 10.18821/1681-3456-2017-16-5-320-324.][Rivard J, Ozog D. Henry Ford Hospital dermatology experience with Levulan Kerastick and blue light photodynamic therapy. J Drugs Dermatol. 2006;5(6):556-561.][Babilas P, Schreml S, Landthaler M, et al. Photodynamic therapy in dermatology: state-of-the-art. Photodermatol Photoimmunol Photomed. 2010;26(3):118–132. doi: 10.1111/j.1600-0781.2010.00507.x.][Peng Q, Soler AM, Warloe T, et al. Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J Photochem Photobiol B. 2001;62(3):140-145. doi: 10.1016/s1011-1344(01)00173-7.][Patent RUS N 2523380 C1. Ponomaryov GV, Kojfman OI, Shestakov VN. Fotosensibilizator i sposob ego polucheniya. (In Russ). Available from: https://yandex.ru/patents/doc/RU2523380C1_20140720.]