Bulletin of the Russian Military Medical AcademyBulletin of the Russian Military Medical Academy1682-73922687-1424Eco-Vector5052510.17816/brmma50525Research ArticleAssociation of arterial hypertension gene polymorphisms with the risk of sudden cardiac death in young peopleKachnovV. A.vmeda-nio@mil.ruTyrenkoV. V.vmeda-nio@mil.ruKolubaevaS. N.vmeda-nio@mil.ruCherkashinD. V.vmeda-nio@mil.ruKutelevG. G.vmeda-nio@mil.ruMyakoshinaL. A.vmeda-nio@mil.ruBuntovskayaA. S.vmeda-nio@mil.ruMilitary medical academy of S.M. Kirov15112020223182219112020Copyright © 2020, Kachnov V.A., Tyrenko V.V., Kolubaeva S.N., Cherkashin D.V., Kutelev G.G., Myakoshina L.A., Buntovskaya A.S.2020<p><strong><em>Abstract</em></strong><strong>.</strong> The frequency of occurrence of arterial hypertension genes in individuals at risk of sudden cardiac death was studied. The relationship between risk factors for sudden cardiac death and the presence of polymorphisms of arterial hypertension genes was revealed. There was a high incidence of homozygous risk variants AGTR2 AA and CYP11B2 TT-polymorphisms responsible for the development of left ventricular hypertrophy, including in young individuals. A correlation was found between deaths in close relatives under 50 years of age and the presence of polymorphisms in the CYP11B2 344 CT gene in young people at risk of sudden cardiac death. We have obtained data indicating the feasibility of conducting a study of the polymorphism of the CYP11B2 gene in the presence of a risk of sudden cardiac death. A direct correlation was found between the presence of fatal outcomes in relatives under 50 years of age by the mechanism of sudden cardiac death and the number of homozygous variants of arterial hypertension genes. Mathematical models for predicting the presence of polymorphisms in genes responsible for the possibility of arterial hypertension are constructed. Among the constructed mathematical models, the most informative were models for detecting carriers of mutations in the genes ADD1 1378 GT, CYP11B2 344 CT and NOS3 894 GT. The expediency of the analysis to search for mutations of arterial hypertension genes, especially in the CYP11B2 344 CT gene, for the possibility of earlier and more intensive preventive measures in young people is shown. The data obtained indicate that there are relationships between the risk of sudden cardiac death, some known predictors of its occurrence, and the genes for arterial hypertension.</p>sudden cardiac deathhypertension geneshypertensionsingle nucleotide polymorphismleft ventricular hypertrophyrenin-angiotensin-aldosterone systemmathematical modelаssociation of gene polymorphismsвнезапная сердечная смертьгены артериальной гипертензиигипертоническая болезньоднонуклеотидный полиморфизмгипертрофия миокарда левого желудочкаренин-ангиотензин-альдостероновая системаматематическая модельассоциация полиморфизмов генов[Бергер, У.В. Структурные полиморфизмы С677Е в гене 5,10–метилентетрагидрофолатредуктазы и А2765G в гене метионинсиснтазы у мужчин, страдающих ишемической болезнью сердца / У.В. Бергер, В.И. Ларионова, Д.В. Черкашин // Вестн. Росс. воен.-мед. акад. – 2014. – № 4 (48). – С. 98–104.][Луцкий, И.С. Ассоциация полиморфных маркеров гена agt с артериальной гипертензией в условиях действия факторов хронического стресса / И.С. Луцкий, М.С. Кишеня // Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. – 2017. – № 19 (268). – С. 54–65.][Милославский, Д.К. Альдостеронсинтаза, полиморфизм ее гена CYP11B2 при артериальной гипертензии и ассоциированных с нею кардиоваскулярных заболеваниях (обзор литературы) / Д.К. Милославский [и др.] // Артериальная гипертензия. – 2017. – № 4 (54). – С. 18–28.][Рекомендации по лечению больных с артериальной гипертензией / B. Williams [et al.] // Росс. кардиол. журн. – 2018. – № 23 (12). – С. 143–228.][Bhandary, U. Endothelial nitric oxide synthase polymorphisms are associated with hypertension and cardiovascular disease in renal transplantation / U. Bhandary [et al.] // Nephrology (Carlton). – 2008. – № 13 (4). – P. 348–355.][Carstens, N. Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure / N. Carstens [et al.] // J. Renin Angiotensin Aldosterone Syst. – 2011. – № 12 (3). – P. 274–280.][Holmes, L. DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension: A Systematic Review and Quantitative Evidence Synthesis / L. Holmes [et al.] // Int. J. Environ. Res. Public Health. – 2019. – № 16 (23). – Р. 1–15.][Mahmood, M. G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension / M. Mahmood [et al.] // Med. Sci. Monit. – 2005. – № 11 (1). – Р. 6–9.][Schmieder, R. Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans / R. Schmieder // J. Am. Coll. Cardiol. – 2001. – № 37 (1). – P. 175–182.][Shenasa, M. Hypertension, left ventricular hypertrophy, and sudden cardiac death / M. Shenasa [et al.] // Int. J. Cardiol. – 2017. – № 15. – Р. 60–63.][Tereshchenko, L. Risk stratification of sudden cardiac death death in hypertension / L. Tereshchenko [et al.] // J. Electrocardiol.– 2017. – № 50 (6). – P. 798–801.]