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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Bulletin of the Russian Military Medical Academy</journal-id><journal-title-group><journal-title xml:lang="en">Bulletin of the Russian Military Medical Academy</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской военно-медицинской академии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1682-7392</issn><issn publication-format="electronic">2687-1424</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">61268</article-id><article-id pub-id-type="doi">10.17816/brmma61268</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical Trials</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intraoperative seizures occurrence in cortical mapping of eloquent areas</article-title><trans-title-group xml:lang="ru"><trans-title>Интраоперационный судорожный синдром при картировании функционально значимых зон коры головного мозга</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="spin">7368-9186</contrib-id><name-alternatives><name xml:lang="en"><surname>Toporkova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Топоркова</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>diagnostician</p></bio><bio xml:lang="ru"><p>врач функциональной диагностики</p></bio><email>fata-morgana0@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9935-3249</contrib-id><contrib-id contrib-id-type="scopus">7004578812</contrib-id><contrib-id contrib-id-type="spin">5452-8634</contrib-id><name-alternatives><name xml:lang="en"><surname>Aleksandrov</surname><given-names>Mikhail V.</given-names></name><name xml:lang="ru"><surname>Александров</surname><given-names>Михаил Всеволодович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical sciences, professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>mdoktor@yandex.ru</email><uri>http://www.almazovcentre.ru/?page_id=64071</uri><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="scopus">14819785400</contrib-id><contrib-id contrib-id-type="spin">1822-0196</contrib-id><name-alternatives><name xml:lang="en"><surname>Tastanbekov</surname><given-names>Malik M.</given-names></name><name xml:lang="ru"><surname>Тастанбеков</surname><given-names>Малик Маратович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical sciences</p></bio><bio xml:lang="ru"><p>доктор медицинских наук</p></bio><email>m.m.tastanbekov@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Research Neurosurgical Institute named after prof. A.L. Polenov (branch of the V.A. Almazov National Medical Research Center)</institution></aff><aff><institution xml:lang="ru">Российский научно-исследовательский нейрохирургический институт им. проф. А.Л. Поленова (филиал Национального медицинского исследовательского центра им. В.А. Алмазова)</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Research Neurosurgical Institute named after prof. A.L. Polenov (branch of the V.A. Almazov National Medical Research Center)</institution></aff><aff><institution xml:lang="ru">Российский научно-исследовательский нейрохирургический институт им. проф. А.Л. Поленова (филиал Национального медицинского исследовательского центра им. В.А. Алмазова)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2021</year></pub-date><volume>23</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>39</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2021-03-15"><day>15</day><month>03</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-06-01"><day>01</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Toporkova O.A., Aleksandrov M.V., Tastanbekov M.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Топоркова О.А., Александров М.В., Тастанбеков М.М.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Toporkova O.A., Aleksandrov M.V., Tastanbekov M.M.</copyright-holder><copyright-holder xml:lang="ru">Топоркова О.А., Александров М.В., Тастанбеков М.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1682-7392/article/view/61268">https://journals.eco-vector.com/1682-7392/article/view/61268</self-uri><abstract xml:lang="en"><p>The effect of structural epilepsy on the frequency of intraoperative convulsive seizures is assessed when mapping functionally significant areas of the cerebral cortex during resection of intracerebral neoplasms. The work is based on the analysis of the results of intraoperative neurophysiological studies at the Polenov Neurosurgical Institute. For the period 2019–2020 87 intraoperative mappings of eloquent cortex were carried out during resections of intracerebral neoplasms: 79 mappings of the motor cortex and 16 mappings of auditory-speech areas during operations with awakening. When mapping the motor zones of the cortex, the frequency of seizures was 5.1%, while mapping the auditory-speech zones with awakening — 18.75%. The division of cases of intraoperative convulsive seizures into two groups: seizures arising from motor mapping and seizures associated with the mapping of auditory zones — reflects differences in factors that affect the excitability of the cerebral cortex. In motor mapping, stimulation occurs against the background of general anesthesia, unlike waking operations. The intensity of stimulation in auditory mapping is higher than in motor mapping in motor mapping. Formally, the current used in motor mapping is significantly higher than in mapping auditory zones. In general, with the development of intraoperative convulsive seizures, the current intensity of cortical stimulation does not exceed the average values required to stimulate functionally significant cortical zones. The presence of epileptic syndrome in patients with intracerebral tumors cannot be considered as a predictor of intraoperative seizure development when performing motor mapping under general anesthesia as well as during surgery with awakening for mapping of motor or auditory verbal zones.</p></abstract><trans-abstract xml:lang="ru"><p>Оценивается влияние структурной эпилепсии на частоту интраоперационных судорожных припадков при картировании функционально значимых зон коры головного мозга в ходе резекции внутримозговых новообразований. В основу работы положен анализ результатов интраоперационных нейрофизиологических исследований в Российском научно-исследовательском нейрохирургическом институте имени профессора А.Л. Поленова. За период 2019–2020 гг. было проведено 87 интраоперационных картирований функционально значимых зон коры головного мозга в ходе резекций внутримозговых новообразований: 79 картирований моторной коры и 16 картирований слухоречевых зон при операциях с пробуждением. При картировании двигательных зон коры частота припадков составила 5,1%, при картировании слухоречевых зон с пробуждением — 18,75%. Деление случаев интраоперационных судорожных припадков на две группы: припадки, возникающие при моторном картировании, и припадки, связанные с картированием слухоречевых зон, — отражает различия в факторах, оказывающих влияние на возбудимость коры головного мозга. При моторном картировании стимуляция происходит на фоне общей анестезии в отличие от операций с пробуждением. Интенсивность стимуляции при слухоречевом картировании выше, чем при моторном картировании. Формально сила тока, используемая при моторном картировании, значительно выше, чем при картировании слухоречевых зон. В целом при развитии интраоперационных судорожных припадков сила тока стимуляции коры не превышает средние значения, требуемые для стимуляции функционально значимых зон коры. Показано, что наличие структурной эпилепсии, ассоциированной с внутримозговыми опухолями, не может рассматриваться как предиктор развития интраоперационных судорожных припадков при выполнении моторного картирования как в условиях общей анестезии, так и при хирургии с пробуждением для картирования слухоречевых зон.</p></trans-abstract><kwd-group xml:lang="en"><kwd>intraoperative neurophysiological monitoring</kwd><kwd>motor mapping</kwd><kwd>structural epilepsy</kwd><kwd>neurophysiology</kwd><kwd>neurosurgery</kwd><kwd>eloquent cortex</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>интраоперационный нейрофизиологический мониторинг</kwd><kwd>моторное картирование</kwd><kwd>структурная эпилепсия</kwd><kwd>нейрофизиология</kwd><kwd>нейрохирургия</kwd><kwd>функционально значимые зоны коры</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Alexandrov MV, Chikurov AA, Toporkova OA, et al. 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