Bulletin of the Russian Military Medical AcademyBulletin of the Russian Military Medical Academy1682-73922687-1424Eco-Vector6357810.17816/brmma63578Research ArticlePossibilities of preclinical diagnosis of anthracycline cardiotoxicity using the technique of "speckle-tracking echocardiography"KryukovEvgeny V.<p>Doctor of medical sciences, professor</p>doctorwox@yandex.ruhttps://orcid.org/0000-0002-8396-1936GolubtsovOleg Y.<p>Assistant head of the department</p>doctorwox@yandex.ruTyrenkoVadim V.<p>Doctor of medical sciences, professor</p>vadim_tyrenko@mail.ruhttps://orcid.org/0000-0002-0470-1109SemelevVyacheslav N.<p>Doctor of medical sciences</p>vsemelev@yandex.ruMakievRuslan G.<p>Doctor of medical sciences</p>moro5555@yandex.ruhttps://orcid.org/0000-0002-2180-6885Military Medical Academy named after S.M. KirovBranch of the Military Medical Academy named after S.M. Kirov1205202123181881703202117032021Copyright © 2021, Kryukov E.V., Golubtsov O.Y., Tyrenko V.V., Semelev V.N., Makiev R.G.2021<p>In case of antitumour anthracyclines therapy of patients with non-Hodgkin lymphomas the possibility of using speckle-tracking echocardiography is being considered. It was found that patients with non-Hodgkin lymphomas have early violations of the left ventricular myocardium during the course of antitumor chemotherapy using anthracyclines. They are characterized by reducing of longitudinal deformation of the myocardium with a gradual spread from the apical to the basal segments of the left ventricle. A statistically significant reduction in global and segmental systolic deformation after the 4th course of chemotherapy (cumulative dose of doxorubicin 333.5 88.5 mg/m<sup>2</sup>) is the earliest marker of left ventricular mechanical dysfunction, appearing before the development of diastolic dysfunction and ejection fraction reduction of the left ventricular. Early violations of myocardial mechanics in the dynamics of the course of antitumour therapy with anthracyclines are identified in the apical area of the left ventricle, it can be connected with circulatory failure in this area. Violations of myocardial mechanics in the apical area of the left ventricle can be an erly predictor of ischemia of this area with possible progression to global contractile muscle dysfunction of the left ventricular. The global longitudinall deformation of the left ventricular myocardium in contrast to ejection fraction of the left ventricular is more sensitive to myocardial damages against the backdrop of chemotherapy using anthracyclines. 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