The article briefly covers the scientific, pedagogical and creative activities of Vladimir Olegovich Samoilov, whose life and fate have been associated with his alma mater for more than six decades. May 7, 2021 Vladimir Olegovich Samoilov turned 80 years old. Vladimir Olegovich — Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Retired Major General of the Medical Service, Honorary Doctor of the Military Medical Academy named after S.M. Kirov. Vladimir Olegovich made a significant contribution to the emergence of an independent scientific discipline in medical universities of the country — medical biophysics, which began to study the fundamental problems of metabolism and bioenergetics at the molecular, cellular and systemic levels. Samoilov developed original training courses in biophysics and medical electronics and headed the Department of Medical Physics for 14 years. Together with the staff of the department, he revived and rebuilt the teaching of higher mathematics and general physics at the Academy on the basis of the deductive method. Since 1974 Biophysics is taught at the Military Medical Academy named after S.M. Kirov as a system of physical and physico-chemical processes underlying life activity. In 1988, V.O. Samoilov was appointed Deputy Head of the Academy for Academic and Scientific Work. In the next six years, under his leadership, the system of basic military medical education was restructured. In 2001 Vladimir Olegovich headed the Department of Normal Physiology. During the difficult time of the change of generations, the department reorganized the educational process and resumed scientific research on the main sections of normal physiology. He formed one of the brightest scientific academic schools, which consists of seven doctors and 22 candidates of science.