Bulletin of the Russian Military Medical AcademyBulletin of the Russian Military Medical Academy1682-73922687-1424Eco-Vector7146410.17816/brmma71464Research ArticleFeatures of microcirculation and metabolism in the skin and soft tissues of the injured area in experimental explosive traumaShperlingIgor A.<p>doctor of medical sciences, professor</p>gniiivm_2@mil.ruhttps://orcid.org/0000-0002-7029-8602RostovtsevSergey O.<p>applicant</p>chitah_serge@live.comhttps://orcid.org/0000-0002-1037-5848ShulepovAlexander V.<p>candidate of medical sciences</p>gniiivm_2@mil.ruhttps://orcid.org/0000-0002-6134-809XKourovAnton S.<p>applicant</p>gniiivm_2@mil.ruhttps://orcid.org/0000-0001-6905-2501BazhenovMichail V.<p>head of the gospital</p>gniiivm_2@mil.ruhttps://orcid.org/0000-0003-2201-3948The State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian FederationThe Military Academy of Logistics named after Army General A.V. Khrulev of the Ministry of Defense of the Russian FederationSaint Petersburg Research Institute of Ambulance named after I.I. Dzhanelidze200420222411011101006202128102021Copyright © 2022, Shperling I.A., Rostovtsev S.O., Shulepov A.V., Kourov A.S., Bazhenov M.V.2022<p>Time, nature, and duration of changes in microcirculation and metabolism, as well as their differences in skin and muscle tissue of the injured area during experimental explosive trauma in rats in different wound process phases, are evaluated. Experimental explosive damage was simulated on 30 Wistar rats. The total condition of rats, their activity, interest in food and water, wound area with characteristic wound healing time calculation, the volume of injured pelvic limb, and changes of microcirculation and metabolism in the skin and skeletal muscles of the paravulnar region were evaluated. The explosive damage has led to a deterioration of microcirculation and metabolism in the skin, and especially, in the muscles of the injured area. Compared to the intact group, the microcirculation deterioration resulted in a decreased constant component of perfusion in the skin and muscles by 57.6% and 40.9% and a decreased vial by 76.9% and 76.5%, respectively (<em>p</em> 0.05), as well as in reducing the fluorescent oxygen intake in the skin and muscles by 25.7% and 51.8% and a complex indicator of effective oxygen exchange by 81.1% and 91.9%, respectively (<em>p</em> 0.05). During the experiment, the microcirculation and metabolism were gradually restored, which is more pronounced in the skin, except for the repeated deterioration of the non-vascular regulation of microcirculation in the muscle (a decreased vial by 29.3% of the norm, <em>p</em> 0.05). Changes in the main indicators of microcirculation and metabolism indicate normal skin defect healing and unsatisfactory muscle defect repair (decreased volume of the injured limb (68% of the norm, <em>p</em> 0.05)), accompanied by the recurrence of extravascular disorders in the muscle. Developing new and improved existing methods of delivering biologically active drugs and drugs to the area of muscular damage in the early days after the injury, which strengthen the local blood flow and create conditions for damaged muscle regeneration, reduce the wound healing time without forming pathological scars.</p>explosive damageDoppler flowmetryskinmetabolic statusmicrocirculationsoft tissuesskeletal muscleslocal blood flowwound healing timeregeneration of damaged musclesвзрывное повреждениедоплеровская флоуметриякожаметаболический статусмикроциркуляциямягкие тканискелетные мышцылокальный кровотоксроки заживления ранырегенерация поврежденных мышц[Anisin AV, Denisov AV, Bozhchenko AP, et al. 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