The functional impact of cytokines of the IL-1 family on the periodontal tissues

Abstract


The understanding of cytokine immunology is of paramount importance for the development of rational methods for the treatment of the periodontal inflammatory diseases. Cytokines belonging to the classical interleukin-1 (IL-1) family, i.e. IL-1-alpha and IL-1-beta along with IL- 18, play a key role in the development of inflammation. Other interleukins of the IL-1 family has recently been identified. They include six cytokines whose genes are localized downstream of the genes for IL-1-alpha and IL-1-beta on chromosome 2 (IL-1F5-10 as well as IL-33, a member of the IL-IR/ Toll-like receptor (TLR) superfamily). IL-1F6, IL-1F8, and IL-1F9 are agonists highly expressed in epithelial cells along with their receptor IL-1Rrp2 which suggests their participation in the protective immune reactions of the skin and the gastrointestinal tract (GIT) including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8 which gives evidence of their possible involvement in the development of periodontitis.

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