THE ROLE OF GENE POLYMORPHISMS VITAMIN D RECEPTOR IN ЭТИОПАТОГЕНЕЗЕ OF PERIODONTITIS

Abstract


Important role in etiopathogines periodontitis play the genetic factors that determine the risk of the development and clinical course of the disease. One of the perspective for the study of the markers of periodontitis is a gene polymorphism of the vitamin D. Vitamin D is able to exert influence on the pathogenesis of periodontitis through the effect on calcium metabolism on the one hand and the immune system on the other, it is the effect of indirectly through the vitamin D receptor (VDR). This review demonstrates the increased in recent years the interest to the influence of gene polymorphisms BP on the development of chronic and aggressive forms of periodontitis in different countries. The data of the literature on this issue is quite erratic, which can be attributed to genetic heterogeneity of samples, as well as various parameters of comparison. Further research is needed communications polymorphisms length of restriction fragments gene BP, with the risk of development of various forms of periodontal disease, carried out in Russia.

Full Text

РОЛЬ ПОЛИМОРФИЗМОВ ГЕНА РЕЦЕПТОРА ВИТАМИНА D В ЭТИОПАТОГЕНЕЗЕ ПАРОДОНТИТА

About the authors

M. S Z’ablitskaya

Email: ziablikms@mail.ru

V. G Atrushkevich


A. M Mkrtumyan


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