The value of antimicrobial peptides in the development of diseases of the oral cavity in children with bronchial asthma

Abstract


Introduction: one of the innate immunityfactors is antimicrobial peptides (cathelicidins (LL-37), defensins (HNP 1-3), secreted by the epithelial cells of oral cavity, neutrophils, lymphocytes and monocytes. The objective of the study was to find out some correlation between the quantity ofsalivary antimicrobial peptides and oral health in children sufferingfrom bronchial asthma. Materials and Methods: the study included 88 children aged 4-16 years. The study was done using immune-enzyme analysis (Hulcut biotech, Netherlands), oral cavity examination, DMF and Green-Vermillion indexes. Results: the level of HNP 1-3 in children suffering from bronchial asthma was lower for sure in decompensated and subcompensatedforms of caries, compared with compensatedform. The LL-37, HNP 1-3 concentration in children with asthma is lower than that in healthy ones.

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About the authors

Yuliya Valer’evna Saakyan

«A.I. Evdokimov Moscow state medical dental University», Ministry of health of Russia

Email: juki-juki@yandex.ru
127473, Moscow, Russia

V. M Elizarova

«A.I. Evdokimov Moscow state medical dental University», Ministry of health of Russia

127473, Moscow, Russia

T. V Vinogradova

«N.I. Pirogov Russian national research medical University» Ministry of Health of Russia

125412, Moscow, Russia
Separate structural subdivision «Scientific-research clinical Institute of Pediatrics»

A. N Pampura

«N.I. Pirogov Russian national research medical University» Ministry of Health of Russia

125412, Moscow, Russia
Separate structural subdivision «Scientific-research clinical Institute of Pediatrics»

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