Assessment of clinical efficacy of gaseous ozone therapy in treatment of caries at the white spot stage


Introduction: Ozone has a profound antibacterial effect on cariogenic microorganisms and able to increase the efficacy of non-invasive caries as well as the ozone-air mixture activates alkaline phosphatase that intensifies the process of mineralization. Objective: Assessment of clinical efficacy of ozone therapy in treatment of caries at the white spot stage. Materials and methods: The randomized controlled trial recruited 86 athletes aged 17 to 21 years. Patients with a diagnosis of caries at the white spot stage were divided into 2 groups of 43. In control group 1 the complex of professional oral hygiene was conducted involving treatment of demineralization focus with ozone and remineralization with 15% suspension of hydroxylapatite Ca, whereas patients of the other group did not receive ozone therapy. Results were evaluated immediately after the procedures conducted as well as 1, 2, 6 and 12 months later on. Results: In groups 1 and 2 the total percentage of positive results after 12 months counted 93,02% and 65,1% respectively. Intensity of staining in group 1reduced from 2,50±0,23 to 0,33±0,12, in group 2 - from 2,25±0,27 to 1,01±0,21. In group 1 stabilization process was indicated in 2 cases, white spots decreased in size in 8 cases and totally disappeared in 30 cases; compared to 9, 11 and 8 cases in group 2 respectively. Process development and its progression were revealed in 3 cases in group 1 and in 15 cases in group 2. Conclusion: The results of this randomized controlled trial revealed that treatment with the ozone-air mixture leads to significant increase of remineralizing therapy efficacy in treatment of caries at the white spot stage and reduces the risk of carious lesion development and its progression almost in 1,5 times.

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About the authors

I. M Makeeva

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

119991, Russian Federation, Moscow
Department therapeutic dentistry

Yuriy Olegovich Paramonov

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

119991, Russian Federation, Moscow
assistant of therapeutic dentistry department of Faculty of Dentistry, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia


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