Positive effect of autologous immune peptides applications in the surgical treatment of inflammatory-destructive periodontal lesions

Abstract


Clinical efficacy of autologous complex immune peptides (ACIP) shown in patients with inflammatory and destructive periodontal lesions. The level of gene recognition expression receptors of innate immunity (TLR4) was studied and beta-defensin (hBD-3) periodontal mucosal epithelial cells and TGF b-1 concentration in gingival fluid. Innate immunity factors analysis was spend before and after surgery using osteoplastic material (ACIP) in dynamics. ACIP immune regulatory effect on the performance of innate immunity was shown.


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About the authors

Oksana Aleksandrovna Zorina

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery Ministry of Health of Russia; «I.M. Sechenov First Moscow State Medical University» the Ministry of Health of Russia

Author for correspondence.
Email: zorina-cniis@yandex.ru
Moscow

Dr. Med. Sci., head the Department of operative dentistry Federal Research institute of stomatology and maxillo-facial surgery, Professor of dentistry «I.M.Sechenov First MSMU»

L. V Gankovskaya

N.I. Pirogov Federal Russian national medical University

Email: info@eco-vector.com
Moscow

R. A Balykin

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery Ministry of Health of Russia

Email: info@eco-vector.com
Moscow

T. P Ivanyushko

«I.M. Sechenov First Moscow State Medical University» the Ministry of Health of Russia

Email: info@eco-vector.com
Moscow

O. A Svitich

«I.M. Sechenov First Moscow State Medical University» the Ministry of Health of Russia; N.I. Pirogov Federal Russian national medical University

Email: info@eco-vector.com
Moscow

V. V Grechenko

N.I. Pirogov Federal Russian national medical University

Email: info@eco-vector.com
Moscow

References

  1. Andrukhov O., Ertlschweiger S., Moritz A., Bantleon H.P., Rausch-Fan X. Different effects of P. gingivalis LPS and E. coli LPS on the expression of interleukin-6 in human gingival fibroblasts. Acta Odontol. Scand. 2014; 72 (5): 337-45. doi: 10.3109/00016357.2013.834535.
  2. Lin J., Bi L., Yu X., Kawai T., Taubman M.A., Shen B., Han X. Porphyromonas gingivalis exacerbates ligature-induced, RANKLdependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4. Infect. Immun. 2014; 82 (10): 4127-34. doi: 10.1128/IAI.02084-14.
  3. Savitri I.J., Ouhara K., Fujita T., Kajiya M., Miyagawa T., Kittaka M., Yamakawa M., Shiba H., Kurihara H. Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells. J. Periodontal Res. 2015; 50 (4): 486-93. doi: 10.1111/jre.12231.
  4. Sun Y., Li H., Sun M.J., Zheng Y.Y., Gong DJ.., Xu Y. Endotoxin tolerance induced by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: alternations in Toll-like receptor 2 and 4 signaling pathway. Inflammation. 2014; 37 (1): 268-76. doi: 10.1007/s10753-013-9737-5.
  5. Sun Y., Shu R., Li C.L., Zhang M.Z. Gram-negative periodontal bacteria induce the activation of Toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells. J. Periodontol. 2010; 81 (10): 1488-96. doi: 10.1902/jop.2010.100004.
  6. Palm E., Demirel I., Bengtsson T., Khalaf H.2. The role of toll-like and protease-activated receptors in the expression of cytokines by gingival fibroblasts stimulated with the periodontal pathogen Porphyromonas gingivalis. Cytokine. 2015; 26: S1043-4666(15)30052-1. doi: 10.1016/j.cyto.2015.08.263.
  7. Park S.R., Kim D.J., Han S.H., Kang M.J., Lee J.Y., Jeong Y.J., Lee S.J., Kim T.H., Ahn S.G., Yoon J.H., Park J.H. Diverse Tolllike receptors mediate cytokine production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infect. Immun. 2014; 82 (5): 1914-20. doi: 10.1128/IAI.01226-13.
  8. Грудянов А.И., Зорина А.И., Зорин В.Л., Переверзев Р.В. Использование аутофибробластов при хирургическом лечении пародонтита. Стоматология. 2013; 5: 19-21.
  9. Ковальчук Л.В., Ганковская Л.В. Иммуноцитокины и локальная иммунокоррекция. Иммунология. 1995; 1: 4-7.
  10. Володин Н.Н., Хабриев Р.У., Ковальчук Л.В., Ганковская Л.В. Медицинская технология «Персонализированная иммунотерапия» утверждена Федеральной службой по надзору в сфере здравоохранения и социального развития (ФС № 2011/212 от 28.07.11).
  11. Ганковская О.А, Ковальчук Л.В., Ганковская Л.В., Лавров В.Ф., Романовская В.В., Карташов Д.Д., Фензелева В.А. Роль Toll-подобных рецепторов и дефенсинов в противомикробной защите урогенитального тракта женщин. Журнал микробиологии, эпидемиологии и иммунологии. 2008; 1: 46-50.
  12. Зорина О.А., Ганковская Л.В., Балыкин Р.А., Свитич О.А., Иванюшко Т.П. Экспрессия генов TLR4 и HBD-3 в эпителиальных клетках слизистой оболочки при хирургическом лечении пародонтита. Стоматология. 2016; 4: 13-5.

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