DIAGNOSIS AND TREATMENT OF HYPOGONADISM IN PATIENTS WITH MANIFESTATION-TIONS OF SIALADENOSIS: DETERMINATION OF STEROID HORMONES IN SALIVA BY TANDEM MASS SPECTROMETRY

Abstract


The authors have studied the steroid hormones in the saliva of patients with hypogonadism who had concomitant sialadens. It is established that sialadens has an impact on preanalytical phase, a further decrease on the background of treatment. The calculated values of concentrations of steroid hormones in saliva in normal and pathological hypogonadism, developed diagnostic criteria based on indicators of testosterone saliva-tion and viscosity of saliva.


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About the authors

S. Yu Kalinchenko

Сhair of endocrinology, University of friendship of peoples

Author for correspondence.
Email: info@eco-vector.com
117198, Мoscow

V. V Afanas’ev

Department of traumatology of the maxillofacial region A.I. Evdokimov Moscow state medico-stomatological University

Email: prof.afanasjev@yandex.ru
127473, Moscow

A. N Nizhnik

Department of mass spectrometry, “Archimedes Clinic”

Email: info@eco-vector.com
119261, Moscow

D. A Belov

Department of mass spectrometry, “Archimedes Clinic”

Email: info@eco-vector.com
119261, Moscow

R. S Stepanenko

Department of traumatology of the maxillofacial region A.I. Evdokimov Moscow state medico-stomatological University

Email: info@eco-vector.com
127473, Moscow

E. S Simenel

Department of mass spectrometry, “Archimedes Clinic”

Email: info@eco-vector.com
119261, Moscow

M. M Damagaev

Department of traumatology of the maxillofacial region A.I. Evdokimov Moscow state medico-stomatological University

Email: info@eco-vector.com
127473, Moscow

O. Yu Vinokurova

Department of traumatology of the maxillofacial region A.I. Evdokimov Moscow state medico-stomatological University

Email: info@eco-vector.com
127473, Moscow

Kh. A Ordashev

Department of traumatology of the maxillofacial region A.I. Evdokimov Moscow state medico-stomatological University

Email: info@eco-vector.com
127473, Moscow

References

  1. Bhasin S., Pencina M., Jasuja G.K., Travison T.G. et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J. Clin. Endocrinol. Metab. 2011; 96 (8): 2430-9.
  2. Lunenfeld B., Mskhalaya G., Zitzmann M., Arver S. et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015; 18 (1): 5-15.
  3. Taylor A.E., Keevil B., Huhtaniemi I.T. Mass spectrometry and immunoassay: how to measure steroid hormones today and tomorrow. Eur. J. Endocrinol. 2015; 173 (2): D1-12.
  4. Goncharov N., Katsya G., Dobracheva A., Nizhnik A. et al. Diagnostic significance of free salivary testosterone measurement using a direct luminescence immunoassay in healthy men and in patients with disorders of androgenic status. Aging Male. 2006; 9 (2): 111-22.
  5. Афанасьев В.В. Слюнные железы. Болезни и травмы. Руководство для врачей. М.: ГЭОТАР-Медиа; 2012.
  6. Методика (метод) измерений массовой концентрации стероидных гормонов в пробах крови методом жидкостной хроматографии - тандемной масс-спектрометрии. МУ 08-47/376. Томск: ФГБОУ ВПО «Томский политехнический университет»; 2015.

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