Russian Journal of DentistryRussian Journal of Dentistry1728-28022413-2934Eco-Vector4308510.18821/1728-2802-2019-23-5-227-231Review ArticleFAMILIAL MEDITERRANEAN FEVER. THE PRESENT-DAY VIEW OF THE PROBLEM. MANIFESTATIONS OF MAXILLOFACIAL AREAKlinovskayaA. SPh.D., docent of the department of oral surgeryklinskaya@inbox.ruGurgenadzeA. P-ZhuruliG. N-BazikyanO. A-AbramyanS. A-Moscow State University of Medicine and Dentistry1512201923522723124082020Copyright © 2019, Eco-Vector2019Periodic disease - hereditary disease spreaded among the ancient peoples of the Mediterranean coast. The questionnaire and retrospective analysis of manifestations of periodic disease for patients living in the Russian Federation was composed in the child-maxillofacial department of the MSMSU named after A.I. Evdokimov. The research of medical histories of patients let us notice that every patient needs individual treatment and prophylaxis of frequent attacks. Nowadays Russian pediatricians are poorly informed about the periodic disease. As a consequence, we have detected a large number of mistakes in the diagnosis.periodic diseasefamilial Mediterranean feverclinical picture and diagnosingcase reportcolchicinereview articleпериодическая болезньсемейная средиземноморская лихорадкаклиника и диагностикаклинический случайколхицинобзор[Drenth G., van der Meer GW. Hereditary Periodic fever. New Engl. J. Med. 2001; 345: 1748-57. https://doi.org/10.1056/NEJMra010200.][Siegal S. Benign paroxysmal peritonitis. Ann. Intern. Med. 1945; 23: 1-21. https://doi.org/10.7326/0003- 4819-23-1-1.][Reimann H.A. Periodic disease а probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia. JAMA. 1948; 136: 239-44. https://doi.org/ 10.1001/jama.1948.02890210023004.][Федоров Е.С., Салугина С.О., Кузьмина Н.Н. Семейная средиземноморская лихорадка (периодическая болезнь): современный взгляд на проблему, Современная ревматология. 2013; 1: 24-30. https://doi.org/10.14412/1996-7012-2013-2363.][Simon A., van der Meer J.W.S. Pathogenesis of familial periodic fever syndromes or hereditary inflammatory syndromes. Am. J. Physi-ol.Regul. Integr. Comp. Physiol. 2007; 292:8 6-98. https://doi.org/ 10.1152/ajpregu.00504.2006.][Lidar M., Livnech А. Familial Mediterranean fever: clinical, molecular and management advancements. Netherl. J. Med. 2007; 65: 318- 24.][Notamicola C., Didelot M.N., Seguret F. et al. Enchanced cytokine mRNA levels in attack-free patients with familial Mediterrnean fever. Genes Immun. 2002;3:43-5. https://doi.org/10.1038/ sj.gene.6363813.][Арутюнян В.М., Акопян Г.С. Периодическая болезнь (этиопа-тогенетические и клинические аспекты). М.: МИА, 2000.][Рамеев В.В., Симонян А.Х., Саркисова И.А. и др. Амилоидоз и наследственные периодические аутовоспалительные синдромы. Клиницист 2008; 2:6-15.][Ozen S. Familial mediterranean fever: revisiting an ancient disease. Eur. J. Pediatr. 2003; 162: 449-54. https://doi.org/10.1007/s00431- 003-1223-x.][Kuijk L.M., Hoffman H.L., Neven B., Frenkel J. Episodic Autoinflammatory Disorders in Children. In: Handbook of Systemic Autoimmune Disease.V.6. Pediatrcs in Systemic Autoimmune Disease. R. Cimas, T. Lehman (eds). Elselvier, 2008; 119-35. https://doi.org/10.1016/S1571-5078(07)06014-X.][Ганджа И.М., Децик Ю.И., Пелещук А.П. и др. Редкие и атипичные синдромы заболевания в клинике внутренних заболеваний/ Под ред. И.М. Ганджи. Киев: Здоров’е, 1982. (in Russian)][Kalinich T., Haffer D., Niehues T. et al. Colchicine Use in Children and Adolescents With Familial Mediterranean Fever. Literature Review and Consensus Statement. Pediatria 2007; 119: 474-83. https:// doi.org/10.1542/peds.2006-1434.]