Vol 21, No 4 (2017)

The article presents the results of an experimental study of bulk activated photodynamic therapy of diseases and microbial processes and neoplastic nature with culture microbes and experimental animals. Showed anti-tumor effect of the chlorophyll-containing drug, is activated by laser body.

The article presents data on the relevance of use of adhesive materials when using removable laminar prostheses under various conditions prosthetic bed in patients with complete absence of teeth; on the development of optimal formulations and methods of making adhesive compositions for removable laminar dentures, modified with silver ions, with pronounced antimicrobial activity, bioinertness and high fixing properties to improve fixation and stabilization of removable partial dentures complete dentition in the period of adaptation of patients to newly manufactured prostheses and in the process further their use; and described in detail a number of studies on the physico-mechanical characteristics of the developed material on the basis of technical laboratories: Federal state budgetary educational institution of higher professional education «Voronezh state medical University named after N. N. Burdenko» Ministry of health of the Russian Federation, company for the production of dental materials «Celite» (Voronezh); and in clinical practice: on the basis of the dental clinic of the «VSMU them. N. N. Burdenko» Ministry of health of Russia and in private dental clinics, under which was revealed quite pronounced fixing properties of the modified compositions in relation to the base removable laminar denture and tissues of the prosthetic bed, when proven to this antibacterial activity and bioinertness developed material, thereby clearly defines the relevance of the use of the adhesive composition, modified with silver ions, as an effective means to improve the fixation and stabilization of removable partial dentures in the oral cavity of patients with complete absence of teeth, contributing to more comfortable with their further operation.

The goal of our study was investigation of prenatal diagnostics of pathology and distribution of associated anomalies in the group of children - patients of clinic with congenital maxillofacial anomalies. Basing on oral poll of mothers given birth to children with the pathology during the period 2012-2014 in Krasnodarskii krai (358 cases), the efficiency of prenatal detection of congenital clefts of lip and palate (diagnosis Q36, Q35 and Q37 by MKB-10) by ultrasonic investigation was studied. Prenatal 2D ultrasonic investigation is performed three times during pregnancy on 12, 18-24 and 32-34 weeks of pregnancy. Cleft lip or palate were detected on the second and third ultrasonic investigation: cleft palate (Q35) was revealed only in 5,6% cases of children born with cleft palate, and cleft palate (Q36 and Q37) - in 33,8% cases. Importance of prenatal ultrasonic diagnostics of pathology is not only predetermined by the necessity of mental conditioning of parents for the most urgent and proper rehabilitation of ill children, but, also, by the fact that patients with clefts of lip or palate frequently have associated pathology of other organs and chromosomal anomaly. For proper prenatal detection of cleft palate 3D ultrasonic investigation is necessary. We also studied the presence of associated pathology distribution for the cases of isolated clefts of lip or palate. Higher efficiency of cleft lip and palate detection in prenatal period by ultrasonic diagnostics would support more successful rehabilitation by well-timed mental conditioning and informing of parents about stages of rehabilitation in the process of child growing. Ethical aspects of probable abortion because of detected pathology during ultrasonic investigation.

The aim of the study was to evaluate bone metabolism in cancer patients with bisphosphonate osteonecrosis of the jaws. The study included 45 people of the main group (patients with cancer with osteonecrosis of the jaw in patients receiving bisphosphonates) and 25 in the control group (cancer patients treated with bisphosphonates, but did not have osteonecrosis of the jaw), which had a stabilization of the underlying disease. Bone metabolism was evaluated by the level of osteocalcin (OC), bone-specific alkaline phosphatase (bALP), aminoterminal of propeptide of procollagen type I (P1NP), tartrate-resistant acid phosphatase (TRAP5b), calcium (Cа), phosphorus (P) in blood serum before treatment and after 6 months. Compared to the average levels of marker patients of the main and control groups using the Mann-Whitney test for p < 0,05. A baseline level of СТХ (0,23±0,02 ng/ml) and OС (11,58±0,54 ng/ml) in the treatment group was significantly (p < 0.05) lower than control group (0,43±0,01 ng/ml and 17,94±0,83 ng/ml), and the level of osteocalcin in the main group (11,58±0,54 ng/ml) was on average below normal 2,59 times. Recorded significantly higher (p < 0,05) levels bALP (133,24±14,03 U/l) and TRAP5b (3,54±0,38 U/l) in patients with osteonecrosis compared with a control group (73,32±3,41 U/l and 3,12±0,12 U/l). Reliably detected differences in the levels of P1NP, Ca and P were not detected (p > 0,05). In the main group after 6 months of treatment was observed a tendency of growth of СТХ, TRAP5b, OK, bALP, P1NP, Ca, but only for the markers of resorption and СТХ, TRAP5b these differences were significant. Indicators of patients in the control group were stable and did not differ in the dynamics. The development of bisphosphonate osteonecrosis of the jaws is directly related to bone metabolism and occurs with predominance of the processes of bone resorption and inhibition of bone formation processes.

The article assesses the most common methods of surgical treatment in patients with mandibular fractures at the body and angle region. Optimal choice of the osteosynthesis modality in order to achieve a good result and minimization of number of complications, still remains a challenge for the maxillofacial surgeon because of the large number of techniques and fixing devices.

Using the method of empirical anonymous sociological research the competence of 630 dentists and health care institutions managers according to the new system of wage payments (NSWP) was studied. On the 7 questions asked, containing about 6138 possible answers from all the respondents 2253 correct answers were retrieved which represents 36,7% of all responses. Found data shows that only every third dental clinic specialist has the competence in NSWP while the majority 63, 3% are not quite oriented in the NSWP. One of the main problems of the NSWP integration is lack of understanding of basic principles and specific criteria of work quality assessment from health care institutions employees thus nullifies the potentially high impact of its introduction. Raise of the transparency of wage payment system will cause significant personnel motivation improvement in achieving qualitative and quantitative labor values that the authority has laid for the organization that are tied to the work goals of the institution itself and the health care system as a whole. Medical institution administration system should use new tools for staff competence improvement nowadays. It is necessary to provide professional communication space for colleagues on the questions of NSWP.

The clinical picture of many systemic diseases (SD) could make its debut in the maxillofacial area with salivary gland lesions. Sjogren’s sicca syndrome, IgG4-related diseases, sarcoidosis, viral hepatitis - C, primary biliary cirrhosis, autoimmune hepatitis, as well as complications of the plurality of abnormalities in the form of lymphoproliferative diseases including AL-amyloidosis and B-cell lymphomas of different malignant tumors. The main diagnostic criteria in this case are the data of histological and immunohistochemistry studies of affected tissues. The aim of this publication is to analyze literature data on the pathological changes developing in salivary glands at different SD. The question about the diagnostic value of limphoplazmatsitarny infiltrate detected in the salivary gland biopsy materials SD and its influence on the prognosis and course of pathological process remains open. Conclusions: salivary glands biopsy has played a significant role in the early diagnosis and follow-up of patients with a variety of SD occurring with salivary gland lesions and such research studies have been required to continue.