Molekulyarnaya Meditsina (Molecular medicine)Molekulyarnaya Meditsina (Molecular medicine)Молекулярная медицина1728-29182499-9490Russkiy Vrach Publishing House11328910.29296/24999490-2020-04-01ArticlesСтатьиResearch ArticleActuality and perspectives of a personal approach to change the immune system functional activity based on micronutrientsАктуальность и перспективы персонализированного подхода к изменению функциональной активности иммунной системы на основе микронутриентовYurasovV. VЮрасовВ. В

кандидат медицинских наук

SadykovA. RСадыковА. РZolkinaI. VЗолкинаИ. В

кандидат биологических наук

KhasbiullinaN. RХасбиуллинаН. Р

кандидат биологических наук

n.hasbiullina@chromolab.ruGlagovskiyP. BГлаговскийП. Б

Научно-исследовательский институт цереброваскулярной патологии и инсульта

MamedovI. SМамедовИ. С

Center for the implementation of innovative medical and pharmaceutical technologies

кандидат медицинских наук

PaltsevM. AПальцевМ. А

академик РАН, профессор

Scientific and Laboratory Complex «Chromolab»Научно-лабораторный комплекс «Chromolab»The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Nikolay Pirogov Russian National Research Medical UniversityНаучно-исследовательский клинический институт педиатрии им. акад. Ю.Е. Вельтищева ФГБОУВО РНИМУ им. Н.И. Пирогова Минздрава РоссииResearch Institute of Cerebrovascular Pathology and Stroke of the Nikolay Pirogov Russian National Research Medical UniversityФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииNikolay Pirogov Russian National Research Medical UniversityФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииLomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»15032020184VOL 18, NO4 (2020)ТОМ 18, №4 (2020)31218112022Copyright ©; 2020, Russkiy Vrach Publishing HouseCopyright ©; 2020, ИД "Русский врач"2020Russkiy Vrach Publishing HouseИД "Русский врач"https://journals.eco-vector.com/1728-2918/article/view/113289

The review article discusses the principles of a personalized approach to changing the functional activity of the immune system based on micronutrients. The activity of the immune cells has been demonstrated to depend on the level of supplied not only macro- but also micronutrients - vitamins and minerals. Given the special needs of the immune system for micronutrients, an assessment of their adequate level is an important step in the development of the principles of personalized medicine. It is promising to measure the level of micronutrients using metabolome technologies. The article considers, the role and importance for the immune system functionality of the following micronutrients: fat-soluble vitamins - A, D, E, K, water-soluble vitamins - B1, B, B, B5, B, B9, BI2, vitamin C and trace elements - selenium, zinc, copper, magnesium, and manganese. The validity of the administration of micronutrients should be based on the analysis of the individual profile of these substances in the particular patient. A similar approach that underlies personalized medicine will not only increase both the efficacy and safety of preventive medical measures but also reduce the cost of expensive procedures, applying to target groups only. When considered as the most important direction in the development of clinical medicine personalized medicine can significantly improve the quality and the results of the treatment.

В обзорной статье рассмотрены принципы персонализированного подхода изменения функциональной активности иммунной системы на основе микронутриентов. Продемонстрировано, что активность клеток иммунной системы зависит от уровня обеспеченности организма не только макро-, но и микронутриентами - витаминами и микроэлементами. Учитывая особые потребности иммунной системы в микронутриентах, оценка их адекватного уровня является важным шагом развития принципов персонализированной медицины. Измерение уровня микронутриентов перспективно проводить с помощью метаболомных технологий. В статье рассмотрена роль и значение для функционирования иммунной системы следующих микронутриентов: жирорастворимых витаминов - A, D, E, K, водорастворимых витаминов - В1, В, В, В5, В, В9, В12, витамина С и микроэлементов - селена, цинка, меди, магния и марганца. Обоснованность назначения пациенту микронутриентов должно базироваться на анализе индивидуального профиля этих веществ у пациента. Подобный подход, лежащий в основе персонализированной медицины, позволит не только повысить эффективность и безопасность профилактических и медикаментозных мер, но и сократить расходы на дорогостоящие процедуры, применяя их только у целевых групп. Персонализированная медицина способна существенно повысить качество и улучшить результаты лечения, ее рассматривают как важнейшее направление развития клинической медицины.

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