Molekulyarnaya Meditsina (Molecular medicine)Molekulyarnaya Meditsina (Molecular medicine)Молекулярная медицина1728-29182499-9490Russkiy Vrach Publishing House11352710.29296/24999490-2021-06-03ArticlesСтатьиReview ArticleHPgV infection: literature reviewHPgV-инфекцияLitvinovValeriy ViktorovichЛитвиновВалерий Викторович

Assistant professor, Department of pathology

доцент кафедры патологической анатомии с секционным курсом, кандидат медицинских наук

drlitvinov@mail.ruFreyndGenrietta GerhardovnaФрейндГенриетта Герхардовна

Head of the department of pathology

заведующая кафедрой патологической анатомии с секционным курсом, доктор медицинских наук, профессор

gfreynd@mail.ruKorobovVladimir PavlovichКоробовВладимир Павлович

Head of the Laboratory of Microorganisms’ Biochemical Development

заведующий лабораторией биохимии развития микроорганизмов, кандидат медицинских наук, доцент

korobov@iegm.ruShestakovaAnna DmitrievnaШестаковаАнна Дмитриевна

Resident doctor

врач-ординатор

message19@rambler.ruFSBEI HE «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian FederationФГБОУ ВО «Пермский государственный медицинский университет им. академика Е.А. Вагнера» Минздрава РоссииFSBSIPerm Federal Research Center «Institute of Ecology and Genetic of Microorganisms» Ural Office of the Russian Academy of SciencesФГБУН Пермского федерального исследовательского центра «Институт экологии и генетики микроорганизмов УрО РАН»FSBI «National medical research center of Oncology named after N.N. Petrov» Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова»15062021196VOL 19, NO6 (2021)ТОМ 19, №6 (2021)192618112022Copyright ©; 2021, Russkiy Vrach Publishing HouseCopyright ©; 2021, ИД "Русский врач"2021Russkiy Vrach Publishing HouseИД "Русский врач"https://journals.eco-vector.com/1728-2918/article/view/113527

Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to 2020. Results: the history of the study of the virus, its structure, genetic heterogeneity, as well as the problem of epidemiology, tropism and pathogenesis of this infection are described. Due to the presence of a number of the virus properties, possible prospects of HPgV infection research for population genetics and gene therapy are reflected. The modern data on the relationship of HPgV infection with HIV infection, lymphomas and some other diseases are presented. A brief description of a relatively recently described HPgV-2 is presented. The problems of diagnosis and interpretation of HPgV infection in the Russian Federation and foreign countries are outlined. Conclusion: Although HPgV was originally described as the cause of hepatitis, it is not a cytopathic virus, and infection is not associated with the development of pathological processes.

Цель: анализ данных литературы по HPgV-инфекции, вызываемой вирусом Human pegivirus-1 (ранее гепатит G, HGV, GBV-C). Материал и методы: поиск, по ключевым словам, публикаций в базах данных Scopus, PubMed и Elibrary за период с 1995 по 2020 г. Результаты: описана история изучения вируса, его строение, генетическая гетрогенность, а также проблема эпидемиологии, тропизма и патогенеза данной инфекции. В связи с наличием ряда свойств вируса отражены возможные перспективы исследования HPgV-инфекции для популяционной генетики и генной терапии. Представлены современные данные о связи HPgV-инфекции с ВИЧ-инфекцией, лимфомами и некоторыми другими заболеваниями. Дана краткая характеристика относительно недавно описанного вируса 2-го типа (HPgV-2). Обозначены проблемы диагностики и интерпретации HPgV-инфекции в Российской Федерации и зарубежных странах. Заключение: несмотря на то, что изначально возбудитель HPgV-инфекции был описан как причина развития гепатита, он не является цитопатическим вирусом, а заражение не связано с развитием патологических процессов.

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