Molekulyarnaya Meditsina (Molecular medicine)Molekulyarnaya Meditsina (Molecular medicine)Молекулярная медицина1728-29182499-9490Russkiy Vrach Publishing House30367710.29296/24999490-2023-01-04ReviewsОбзорыReview ArticlePremature aging (inflamaging) and diseases of the female reproductive systemИнфламэйджинг (inflamaging): роль и значение в патогенезе заболеваний женской репродуктивной системыhttps://orcid.org/0000-0002-4209-7133ShteimanAnastasia A.ШтейманАнастасия Андреевна
Russian Federation

Researcher, Institute of Bioregulation and Gerontology

научный сотрудник АННО ВО НИЦ «Санкт-Петербургский институт биорегуляции и геронтологии»

anastasia2404@gmail.comhttps://orcid.org/0000-0002-8698-7904KrylovaYuliya S.КрыловаЮлия Сергеевна
Russian Federation

Assistant of the Department of Pathological Anatomy of the First St. Petersburg State Medical University. acad. I.P. Pavlov, Senior Researcher, Center for Molecular Biomedicine, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation. Candidate of Medical Sciences.

ассистент кафедры патологической анатомии Первого Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова». Старший научный сотрудник Центра молекулярной биомедицины ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава РФ. Кандидат медицинских наук.

emerald2008@mail.ruhttps://orcid.org/0000-0002-7834-5522DokhovMikhail A.ДоховМихаил Александрович
Russian Federation

Associate Professor of the Department of Medical Informatics, St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia. Senior Researcher at the Center for Molecular Biomedicine, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation. Candidate medical sciences.

доцент кафедры медицинской информатики ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет Минздрава России». Старший научный сотрудник Центра молекулярной биомедицины ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава РФ. Кандидат медицинских наук.

mad20@mail.ruhttps://orcid.org/0000-0001-9518-2916ZubarevaTatyana S.ЗубареваТатьяна Станиславовна
Russian Federation

Senior Researcher, Center for Molecular Biomedicine, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation. Candidate of Biological Sciences.

Старший научный сотрудник Центра молекулярной биомедицины ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава РФ. Кандидат биологических наук.

tz6.6@bk.ruhttps://orcid.org/0000-0001-6981-2531LeontievaDarya O.ЛеонтьеваДарья Олеговна
Russian Federation

laboratory researcher at the Center for Molecular Biomedicine, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation

лаборант-исследователь Центра молекулярной биомедицины ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава РФ

leontiewadar@yandex.ruhttps://orcid.org/0000-0001-5991-0066BotinaAnna V.БотинаАнна Вячеславовна
Russian Federation

Associate Professor, Department of Pathological Anatomy, First St. Petersburg State Medical University named after I.I. acad. I.P. Pavlova, Candidate of Medical Sciences

доцент кафедры патологической анатомии Первого Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова» Кандидат медицинских наук

botinaanna@mail.ruhttps://orcid.org/0000-0002-7491-3860TikhomirovaAleksandra A.ТихомироваАлександра Александровна
Russian Federation

Head of the Department of Medical Informatics, St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia, Candidate of Economic Sciences

заведующий кафедрой медицинской информатики ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет Минздрава России», Кандидат экономических наук

tikhomirova@bk.ruSt. Petersburg Institute of Bioregulation and GerontologyСанкт-Петербургский институт биорегуляции и геронтологииFGBOU VO «First St. Petersburg Statemedical university. acad. I.P. Pavlova» Ministry of Health of the Russian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» МЗ РФSt. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian FederationФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФSt. Petersburg State Pediatric Medical University, Ministry of Health of the Russian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» МЗ РФ0103202321130360103202301032023Copyright ©; 2023, Russkiy Vrach Publishing HouseCopyright ©; 2023, ИД "Русский врач"2023Russkiy Vrach Publishing HouseИД "Русский врач"https://journals.eco-vector.com/1728-2918/article/view/303677

Relevance. The review is devoted to the issue of aging and the relationship of the molecular processes of aging with the pathology of the reproductive system

The aim of the study was to review the current understanding of aging, the mechanisms and role in the pathology of diseases such as endometriosis, premature ovarian failure and to find possible potential points of treatment.

Material and methods: the analysis and systematization of literature over the past 5 years in the PubMed, Scopus and Google Scholar databases was carried out.

Results. The review reflects the main mechanisms involved in the aging of the reproductive system, the impact on which is possible both by medication and by modifying lifestyle and nutrition. What can make it possible to reduce the number of side effects from the use of the main, hormonal, treatment

Актуальность. Обзор посвящен взаимосвязи молекулярных процессов старения с патологией репродуктивной системы

Целью исследования было рассмотреть современные представления о старении, механизмы инфламейджинга и его роль в патологии таких заболеваний как эндометриоз, преждевременное истощение яичников и определить потенциальные мишени лечебного воздействия.

Материал и методы: проведен анализ и систематизация литературы за последние 5 лет в базах данных PubMed, Scopus и Google Scholar.

Результаты. В обзоре отражены основные механизмы, участвующие в старении репродуктивной системы, воздействие на которые как медикаментозными средствами, так и модификацией образа жизни и питания, позволит снизить число побочных эффектов при применении основного, гормонального, лечения.

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