Molekulyarnaya Meditsina (Molecular medicine)Molekulyarnaya Meditsina (Molecular medicine)Молекулярная медицина1728-29182499-9490Russkiy Vrach Publishing House62693210.29296/24999490-2024-01-03ReviewsОбзорыReview ArticleBiomarkers of endothelial damage and their role in predicting the development of sepsis and septic shockБиомаркеры повреждения эндотелия и их роль в прогнозировании развития сепсиса и септического шокаhttps://orcid.org/0000-0003-3451-1952KhomyakovaTatyana I.ХомяковаТатьяна Ивановна
Russian Federation

Senior Researcher of the Laboratory of Immunomorphology of Inflammation

старший научный сотрудник лаборатории иммуноморфологии воспаления

tatkhom@yandex.ruhttps://orcid.org/0000-0002-4288-3791BabaevMaksim A.БабаевМаксим Александрович
Russian Federation

Chief Researcher of the Department of Cardiac Resuscitation

главный научный сотрудник отделения кардиореанимации

maxbabaev@mail.ruhttps://orcid.org/0000-0002-9672-7145PonomarenkoElena A.ПономаренкоЕлена Алексеевна
Russian Federation

Senior Researcher of the Laboratory of Immunomorphology of Inflammation

старший научный сотрудник лаборатории иммуноморфологии воспаления

ponomarenkoea75@mail.ruhttps://orcid.org/0000-0003-0540-252XKhomyakovYury N.ХомяковЮрий Николаевич
Russian Federation

Head of the Laboratory of Molecular Microbiology and Epidemiology of Mycobacterial Infections

заведующий лабораторией молекулярной микробиологии и эпидемиологии микобактериальных инфекций

khomyakovyuri@yandex.ruResearch Institute of Human Morphology named after. acad. A.P. Avtsyn Federal State Budgetary Scientific Institution “Russian Scientific Center for Chemistry named after. acad. B.V. Petrovsky»НИИ морфологии человека им. акад. А.П. Авцына ФГБНУ «РНЦХ им. акад. Б.В. Петровского»FGBNU «RNTsKh im. acad. B.V. Petrovsky»ФГБНУ «РНЦХ им. акад. Б.В. Петровского»FBUN Central Research Institute of Epidemiology of RospotrebnadzorФБУН ЦНИИ Эпидемиологии Роспотребнадзора1502202422121281402202414022024Copyright ©; 2024, Russkiy Vrach Publishing HouseCopyright ©; 2024, ИД "Русский врач"2024Russkiy Vrach Publishing HouseИД "Русский врач"https://journals.eco-vector.com/1728-2918/article/view/626932

Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as the structural basis of the circulatory system, is primarily exposed to pathogenetic factors, performing a protective function.

The purpose of this review was to summarize the results of assessing the diagnostic and prognostic effectiveness of molecular markers of endothelial damage in the development of inflammation, sepsis and septic shock.

Material and methods. The literature search was conducted using the databases PubMed/Medline, Elsevier.com., ResearchGate, RSCI/elibrary, over the past ten years.

Results. Using keywords, 215 articles were found and analyzed, from which 70 of the most significant and reliable sources were selected. It was concluded that it is necessary to develop a panel of markers of endothelial damage, which together will provide high reliability and specificity for assessing the risk of developing sepsis and septic shock.

Введение. Сепсис – это полиорганная дисфункция в ответ на генерализацию инфекционного процесса. Вероятность развития сепсиса коррелирует с значением биохимических параметров, которые могут служить прогностическими маркерами. Эндотелий, как структурная основа системы кровообращения, в первую очередь подвергается воздействию патогенетических факторов, выполняя защитную функцию.

Целью данного обзора было обобщение результатов оценки диагностической и прогностической эффективности молекулярных маркеров эндотелиального повреждения при развитии воспаления, сепсиса и септического шока.

Материал и методы. Поиск литературы проводился по базам данных PubMed/Medline, Elsevier.com., ResearchGate, РИНЦ/elibrary, за последние десять лет.

Результаты. По ключевым словам было найдено и проанализировано 215 статей, из которых было выбрано 70 наиболее значимых и достоверных источников. Сделан вывод о необходимости разработки панели маркеров повреждения эндотелия, которые в совокупности обеспечат высокую достоверность и специфичность оценки риска развития сепсиса и септического шока.

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