Molekulyarnaya Meditsina (Molecular medicine)Molekulyarnaya Meditsina (Molecular medicine)Молекулярная медицина1728-29182499-9490Russkiy Vrach Publishing House63502210.29296/24999490-2024-04-03ReviewsОбзорыReview ArticleKey markers of ferroptosisКлючевые маркеры ферроптозаhttps://orcid.org/0000-0002-2895-336XTokhtuevaMaria D.ТохтуеваМария Дмитриевна
Russian Federation

research engineer at the Laboratory of Primary Bioscreening, Cellular and Gene Technologies of the Scientific, Educational and Information Center for Chemical and Pharmaceutical Technologies of the Institute of Chemical Technology

инженер-исследователь Лаборатории первичного биоскрининга, клеточных и генных технологий Научно-образовательного и информационного центра химико-фармацевтических технологий Химико-технологического института

maria.tokhtueva@urfu.ruhttps://orcid.org/0000-0003-3107-8532MelekhinVsevolod V.МелехинВсеволод Викторович
Russian Federation

PhD of Medical Sciences, Associate Professor, Head of the Laboratory of Primary Bioscreening, Cellular and Gene Technologies of the Scientific, Educational and Information Center for Chemical and Pharmaceutical Technologies of the Institute of Chemical Technology of the FSAEI HE “Ural Federal University named after the first President of Russia B.N. Yeltsin”; Associate Professor of the Department of Medical Biology and Genetics of the FSAEI HE “Ural Federal State Medical University”

кандидат медицинских наук, доцент, заведующий Лаборатории первичного биоскрининга, клеточных и генных технологий Научно-образовательного и информационного центра химико-фармацевтических технологий Химико-технологического института ФГАОУ ВО «Уральский федеральный университет им. первого Президента России Б.Н. Ельцина»; доцент кафедры медицинской биологии и генетики ФГБОУ ВО «Уральский государственный медицинский университет» Министерство здравоохранения Российской Федерации

v.v.melekhin@urfu.ruFederal State Autonomous Educational Institution of Higher Education “Ural Federal University named after the first President of Russia B.N. Yeltsin” of the Ministry of Science and Higher Education of the Russian FederationФГАОУ ВО «Уральский федеральный университет имени первого Президента России Б.Н. Ельцина» Министерства науки и высшего образования Российской ФедерацииFederal State Budgetary Educational Institution of Higher Education “Ural Federal State Medical University”, Healthcare Ministry of RussiaФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации1008202422418270908202409082024Copyright ©; 2024, Russkiy Vrach Publishing HouseCopyright ©; 2024, ИД "Русский врач"2024Russkiy Vrach Publishing HouseИД "Русский врач"https://journals.eco-vector.com/1728-2918/article/view/635022

Introduction. Ferroptosis is a type of programmed cell death associated with excessive accumulation of endogenous iron in the cell, accompanied by the production of reactive oxygen species and, as a result, lipid peroxidation. The literature review examines the key markers of ferroptosis, which is one of the types of programmed cell death other than apoptosis, necroptosis, pyroptosis, etc.

Purpose: to collect and process information on the main markers of ferroptosis, which will allow to adapt and optimize the processes of its study.

Material and methods: analysis of literary sources of domestic and foreign origin on a given topic.

Results: articles have been found and analyzed, including those from the last 5 years, confirming the prospects of ferroptosis as a potential pharmacological target. Conclusion. Understanding the main signs of the launch of this process is an integral part of the research work aimed at finding new therapeutic targets associated with the launch of ferroptosis, which, in turn, represents a promising pharmacological model, since It has a high potential for the future treatment of drug-resistant types of pathologies.

Введение. Ферроптоз – тип программируемой клеточной гибели, связанный с избыточным накоплением эндогенного железа в клетке, сопровождающийся выработкой активных форм кислорода и, как следствие, перекисным окислением липидов. В литературном обзоре рассмотрены ключевые маркеры ферроптоза, который является одним из типов программируемой смерти клеток, отличной от апоптоза, некроптоза, пироптоза и пр.

Цель: сбор и обработка информации по основным маркерам ферроптоза, которая позволит адаптировать и оптимизировать процессы его изучения.

Материал и методы: анализ литературных источников отечественного и зарубежного происхождения по заданной теме.

Результаты: найдены и проанализированы статьи, в том числе за последние 5 лет, подтверждающие перспективность ферроптоза как потенциальной фармакологической мишени.

Заключение. Понимание основных признаков запуска данного процесса является неотъемлемой частью исследовательской работы, направленной на поиск новых терапевтических мишеней, связанных с запуском ферроптоза, который, в свою очередь, представляет собой перспективную фармакологическую модель, т.к. имеет высокий потенциал для будущего лечения лекарственно-резистентных видов патологий.

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