Parameters of nocturnal penile tumescence monitoring as potential predictors of the coronary heart disease
- Authors: Kamalov A.A.1, Orlova Y.A.1, Chalyi M.E.1, Okhobotov D.A.1, Strigunov A.A.1, Nesterova O.Y.1, Makeeva E.A.2
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Affiliations:
- Lomonosov Moscow State University
- Russian University of Medicine
- Issue: No 4 (2024)
- Pages: 16-21
- Section: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/636269
- DOI: https://doi.org/10.18565/urology.2024.4.16-21
- ID: 636269
Cite item
Abstract
Aim. To determine the possibilities of nocturnal penile tumescence (NPT) monitoring in the detection of coronary heart disease (CHD).
Materials and methods. A total of 100 patients were included in the study, of them 50 men had a confirmed diagnosis of CHD and 50 patients consisted the control group. In all patients, flow-dependent vasodilation of the brachial artery and pulse wave velocity were evaluated. The assessment of the quality of erection was carried out using IIEF-15 questionnaire (erectile domain) and Androscan NPT monitoring device. The relative increase in the diameter of the penis (rIn), the duration of NPT with rIn greater than or equal to 30% and 20%, respectively (dNPT with rIn≥30% and dNPT with rIn≥20%) were estimated.
Results. The age of the patients in both groups was comparable with a median of 58.0 years. Patients with CHD had a higher body mass index (BMI) than patients without CHD (29.2 kg/m2 vs. 26.9 kg/m2, respectively; p=0.011). In those without CHD, erectile function was better, both according to the IIEF-15 questionnaire and according to the monitoring of NPT. The model with the maximum coefficient of determination (R2 =32.1%) predicting the probability of having CHD included age, BMI, rIn and dNPT with rIn≥20%. The chance of having CHD increased by 10.5% and 1.6% with a decrease in rIn by 1% and a decrease in dNPT with rIn≥20% for 1 minute. The sensitivity and specificity of the model was 74% and 65.3%, respectively.
Conclusion. Monitoring of the NPT is an important tool for the diagnosis of vascular ED. Based on the results, it is possible to assess the probability of CHD. In contrast to the IIEF-15 questionnaire, NPT, dNPT with rIn≥20% and rIn are more likely to suggest the presence of CHD. The lower the OP and dNPT with rIn ≥20%, the higher the probability of having CHD.
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About the authors
A. A. Kamalov
Lomonosov Moscow State University
Email: armais.kamalov@rambler.ru
ORCID iD: 0000-0003-4251-7545
PhD, MD, Professor, Academician of the RAS, Director of the Medical Research and Educational Center, Head of the Department of Urology and Andrology, Faculty of Fundamental Medicine
Russian Federation, MoscowYa. A. Orlova
Lomonosov Moscow State University
Email: YAOrlova@mc.msu.ru
ORCID iD: 0000-0002-8160-5612
Ph.D., MD, Professor, Leading Researcher at the Department of Urology and Andrology of Medical Scientific and Educational Center, Head of the Department of Internal Medicine, Faculty of Fundamental Medicine
Russian Federation, MoscowM. E. Chalyi
Lomonosov Moscow State University
Email: chalyy@bk.ru
ORCID iD: 0000-0003-1736-9085
PhD, MD, Professor, Leading Researcher at the Department of Urology and Andrology of Medical Scientific and Educational Center
Russian Federation, MoscowD. A. Okhobotov
Lomonosov Moscow State University
Email: 14072003m@mail.ru
ORCID iD: 0000-0002-6768-9004
PhD, MD, Urologist, Researcher at the Department of Urology and Andrology of Medical Scientific and Educational Center, Associate Professor at the Department of Urology and Andrology of Faculty of Fundamental Medicine
Russian Federation, MoscowA. A. Strigunov
Lomonosov Moscow State University
Email: an-strigunov@yandex.ru
ORCID iD: 0000-0003-4518-634X
Urologist, Trainee Researcher at the Department of Urology and Andrology, Medical Scientific and Educational Center
Russian Federation, MoscowO. Yu. Nesterova
Lomonosov Moscow State University
Author for correspondence.
Email: oy.nesterova@gmail.com
ORCID iD: 0000-0003-3355-4547
PhD, Urologist, Researcher at the Department of Urology and Andrology at the Medical Scientific and Educational Center, Senior Tutor of the Department of Urology and Andrology of Faculty of Fundamental Medicine
Russian Federation, MoscowE. A. Makeeva
Russian University of Medicine
Email: makeevazhenia672@gmail.com
ORCID iD: 0009-0001-0485-632X
6th-Year Student of the Semashko Institute of Clinical Medicine
Russian Federation, MoscowReferences
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