UrologiiaUrologiiaУрология1728-29852414-9020Bionika Media29647010.18565/urology.2019.1.126-130ArticlesСтатьиResearch ArticleMolecular basis of intratumoral heterogeneity of urinary tract urothelial carcinomaМолекулярные основы внутриопухолевой гетерогенности уротелиальных карцином мочевыделительной системыOsmanovY. IОсмановЮ. И

Ph.D., head of the Department of Pathology; assistant professor of Department of Pathology named after A.I. Strukov

к.м.н., заведующий патологоанатомическим отделением; доцент кафедры патологической анатомии им. А.И. Струкова

osmanovyouseef@yandex.ruGaibovJ. AГаибовЖ. А

pathologist at the Department of Pathology

врач-патологоанатом

morf_jam.@mail.ruKoganE. AКоганЕ. А

MD, professor, Head of the Department of Pathology named after A.I. Strukov

д.м.н., профессор, заведующая кафедрой патологической анатомии им. А.И. Струкова

koganevg@gmail.comRapoportL. MРапопортЛ. М

MD, professor, Deputy Director for Clinical Care of the Research Institute for Uronephrology and Human Reproductive Health

д.м.н., профессор, заместитель директора НИИ уронефрологии и репродуктивного развития человека

leonidrapoport@yandex.ruScientific Clinical Center of Russian RailwaysНУЗ НКЦ ОАО РЖДI.M. Sechenov First Moscow State Medical UniversityГБОУ «Первый медицинский университет им. И. М. Сеченова» (Сеченовский Университет)150220191NO1 (2019)№1 (2019)12613027022023Copyright ©; 2019, Bionika MediaCopyright ©; 2019, ООО «Бионика Медиа»2019Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/1728-2985/article/view/296470

In the article the main mechanisms of molecular pathogenesis of urinary tract urothelial carcinoma are presented. Two different molecular pathways that determine the development of non-invasive and invasive urothelial carcinoma, the immunohistochemical spectrum of stem markers and aspects of the carcinogenesis of multifocal and recurrent tumors are considered.

В статье представлены основные молекулярные механизмы патогенеза уротелиального рака мочевыделительной системы. Рассмотрено два молекулярных пути, определяющих развитие поверхностной и инвазивной уротелиальной карциномы, иммуногистохимический спектр стволовых маркеров и аспекты канцерогенеза множественных и рецидивных опухолей.

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