UrologiiaUrologiiaУрология1728-29852414-9020Bionika Media31267310.18565/urology.2021.4.145-151ArticlesСтатьиResearch ArticleReflux nephropathy in children: pathogenesis and prognosis. Part 2Рефлюксная нефропатия у детей: патогенез и прогноз. Часть 2MorozovaO. LМорозоваО. Л

Doctor of Medical Sciences, professor, Department of Pathophysiology

д.м.н., профессор кафедры патофизиологии

morozova_ol@list.ruLakomovaD. YЛакомоваД. Ю

Ph.D., associate professor at the Department of Pediatric Surgery

к.м.н., доцент кафедры детской хирургии

dlmedic@mail.ruZakharovaN. BЗахароваН. Б

Doctor of Medical Sciences, professor, Department of clinical and laboratory diagnostics

д.м.н., профессор кафедры клинической лабораторной диагностики

lipidgormon@mail.ruMaltsevaL. DМальцеваЛ. Д

Ph.D., associate professor at the Department of Pathophysiology

к.м.н., доцент кафедры патофизиологии

lamapost@mail.ruManasovaZ. ShМанасоваЗ. Ш

Ph.D., associate professor at the Department of Pathophysiology

к.м.н., доцент кафедры патофизиологии

butri78@mail.ruMorozovD. AМорозовД. А

MD, professor at the Department of Pediatric Surgery, Urology and Andrology

д.м.н., профессор, заведующий кафедрой детской хирургии, урологии и андрологии

damorozov@list.ruSechenov First Moscow State Medical University(Sechenov University)ФГАОУ ВО «Первый МГМУ им. И. М. Сеченова» Минздрава России (Сеченовский Университет)Saratov State Medical University n. a. V.I. RazumovskyФГБОУ ВО «Саратовский ГМУ им. В. И. Разумовского» Минздрава РоссииSechenov First Moscow State Medical University(Sechenov University)ФГБОУ ВО «Саратовский ГМУ им. В. И. Разумовского» Минздрава России150820214NO4 (2021)№4 (2021)14515103032023Copyright ©; 2021, Bionika MediaCopyright ©; 2021, ООО «Бионика Медиа»2021Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/1728-2985/article/view/312673

The second part of this review is devoted to the issues of modern and promising diagnosis of RN in children. The advantages and limits of the available methods for recording the structural and functional state of the kidneys in childhood are considered. Particular attention is paid to possibilities non-invasive methods for diagnosis and prediction of the disease course. Data on promising biomarkers of the early stages of RN formation and progression are presented. For the purpose of a comprehensive and adequate assessment of morphological changes in the kidneys, the necessity of studying various combinations of cytokines in biological media with the subsequent determination of the optimal spectrum is shown. The sensitivity and specificity of molecular indicators of renal damage reviewed as potential targets for renoprotective therapy in the nearest future.

Вторая часть данного обзора посвящена вопросам современной и перспективной диагностики рефлюксной нефропатии (РН) у детей. Рассмотрены преимущества и ограничения имеющихся методов регистрации структурно-функционального состояния почек в детском возрасте. Особое внимание уделено возможностям неинвазивных методов диагностики и прогнозирования течения патологии. Изложены данные о перспективных биомаркерах ранних этапов формирования и прогрессирования РН. В целях комплексной и адекватной оценки патоморфологических изменений в почках показана необходимость исследования в биологических средах различных комбинаций цитокинов с последующим определением оптимального спектра. В рамках изучения данных о чувствительности и специфичности молекулярных индикаторов почечного повреждения представлены потенциальные мишени ренопротективной терапии.

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