UrologiiaUrologiiaУрология1728-29852414-9020Bionika Media32215410.18565/urology.2017.6.131-137ArticlesСтатьиReview ArticleTHE ROLE OF STRESS-INDUCED CHRONIC SUBCLINICAL INFLAMMATION IN THE PATHOGENESIS OF THE CHRONIC PELVIC PAIN SYNDROME IIIB IN MENРоль стресс-индуцированного хронического субклинического воспаления в патогенезе синдрома хронической тазовой боли IIIB у мужчинShormanovI. SШормановИ. С

Dr.Med.Sci., Prof., Head of the Department of Urology with Nephrology

д.м.н., профессор, заведующий кафедрой урологии с нефрологией

kafuro@mail.ruMozhaevI. IМожаевИ. И

Senior Laboratory Assistant at the Department of Urology with Nephrology

старший лаборант кафедры урологии с нефрологией

kafuro@mail.ruSokolovaKh. AСоколоваХ. А

Ph.D., Associate Professor at the Department of Urology with Nephrology

к.м.н., доцент кафедры урологии с нефрологией

manoylov@yandex.ruSolov’evA. SСоловьевА. С

Teaching Assistant at the Department of Urology with Nephrology

ассистент кафедры урологии с нефрологией

kafuro@mail.ruYSMU of the Ministry of Health of the Russian FederationФГБОУ ВО ЯГМУ Минздрава РФ151220176NO6 (2017)№6 (2017)13113707042023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/1728-2985/article/view/322154

This literature review of recent clinical and experimental studies describes the role of oxidative stress in the multifactorial and interdisciplinary pathogenesis of non-inflammatory chronic pelvic pain syndrome IIIB (CPPS-IIIB) in men. The authors outline general biological nature of oxidative stress and its mechanisms. More detailed information is presented on cytokine-mediated chronic subclinical inflammation, one of the key mechanisms of oxidative stress, which is currently being actively studied. It is shown that the imbalance between pro- and anti-inflammatory cytokines observed in patients with CPPS-IIIB can explain some features of the clinical course (in particular, the characteristics of the pain syndrome) and the progression of this disease. In this regard, cytokine profiling of prostatic secretion can provide valuable diagnostic, prognostic and monitoring information in the management of this category of patients. Recently published evidence has demonstrated the essential role of the cytokine-mediated chronic inflammatory response as a mechanism of oxidative stress in the pathogenesis of CPPS-IIIB. Further studies in this area are warranted and in the long term may become a basis for the development of new effective pathogenetic pharmacotherapy of CPPS-IIIB.

В обзоре литературы на основе результатов современных доказательных клинико-экспериментальных исследований представлена роль окислительного стресса в мультифакторном и междисциплинарном патогенезе невоспалительного СХТБ (СХТВ-ІІІБ) у мужчин. Кратко рассмотрены общебиологическая сущность окислительного стресса и его механизмы. Более подробная информация представлена по одному из ключевых механизмов окислительного стресса, который в настоящее время активно изучается, - хроническому субклиническому воспалению, опосредованному цитокинами. Показано, что дисбаланс между про- и противовоспалительными цитокинами, наблюдающийся у больных СХТВ-ШБ, может объяснять некоторые особенности клинического течения (в частности, характеристики болевого синдрома) и прогрессирования данного заболевания. В связи с этим исследование цитокинового статуса секрета предстательной железы может привнести ценную диагностическую, прогностическую и мониторинговую информацию при ведении этой категории больных. Доказательные исследования последних лет демонстрируют существенную роль цитокинопосредованной хронической воспалительной реакции как механизма окислительного стресса в патогенезе СХТВ-ШБ. Работы в данном направлении являются актуальными и в перспективе могут стать основой для разработки новых эффективных патогенетических методов фармакотерапии СХТВ-ІІІБ.

oxidative stresschronic subclinical inflammationcytokinesinterleukinspathogenesisсиндром хронической тазовой боли категории ІІІБокислительный стрессхроническое субклиническое воспалениецитокиныинтерлейкиныпатогенезchronic pelvic pain syndrome ІІІБHarman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1957;2:298-300.Wisnovsky S., Lei E.K., Jean S.R., Kelley S.O. Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell. Cell Chem Biol. 2016;23(8):917-927. pii: S2451 -9456(16)30205-7.Sastre J., Pallardo F.V., Garcia de la Asuncion J., Vina J. Mitocondria, oxidative stress and aging. Free Rad Res. 2000;32:189-198.Harman D. The free radical theory of aging. Antioxid Redox Signal. 2003;5:557-561.Strotskii A.V. Chronic prostatitis: a «new» approach to the old problem? Med. Novosti. (Med. News). 2006;8:19-22.Mehik A., Hellström P., Lukkarinen O., Sarpola A., Järvelin M. Epidemiology of prostatitis in Finnish men: a population -based cross -sectional study. BJU Int. 2000;86(4):443-448.Tyuzikov I.A., Ivanov A.P. Abakterial syndrome of chronic pelvic pain in men as a multidisciplinary problem Fundamental’nyye issledovaniya. (Fundamental research). 2012;1:121-124.Tyuzikov I.A. Interrelation of system factors in the pathogenesis of chronic pelvic pain syndrome in men. Urologiia. 2012;6:48-51.Cohen J.M., Fagin A.P., Hariton E., Niska J.R., Pierce M.W., Kuriyama A., Whelan J.S., Jackson J.L., Dimitrakoff J.D. Therapeutic intervention for chronic prostatitis chronic pelvic pain syndrome (CP CPPS): a systematic review and meta -analysis. PLoS One. 2012;7(8):e41941.Menshchikova E.B., Lankin V.Z., Zenkov N.K., Bondar I.A., Krugovykh N.F., Trufakin V.A. Oxidative stress - Prooxidants and antioxidants M.: Firma «Slovo». (Moscow: firm Word). 2006;556.Kalinchenko S.Yu., Vorslov L.O., Tyuzikov I.A., Tishova Yu.A. Oxidative stress as the cause of systemic aging. The role of preparations of alpha -lipoic acid (Espa -Lipon) in the treatment and prevention of age -associated diseases. Farmateka. (Pharmacy) 2014;6:45-56.Gratas-Delamarche A., Derbré F., Vincent S., Cillard J. Physical inactivity, insulin resistance, and the oxidative -inflammatory loop. Free Radic Res. 2014;48(1):93-108.Bartz R.R., Piantadosi C.A. Clinical review: oxygen as a signaling molecule. Crit Care. 2010;14(5):234.Romano A.D., Serviddio G., de Matthaeis A., Bellanti F., Vendemiale G. «Oxidative stress and aging». J. Nephrol. 2010;23(15):29-36.Carmeli E., Coleman R., Reznick A.Z. The biochemistry of aging muscle. Exp Gerontol. 2002;37:477-489.Vorslov L.O., Kalinchenko S.Yu., Gadzieva I.V. «Quartet of health» against the «death quartet» part one: metabolic neuropathy, easy to diagnose, difficult to treat. Effective pharmacotherapy. Urologiia. 2013;1:38-47Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-247.Kim B., Song Y.S. Mitochondrial dynamics altered by oxidative stress in cancer. Free Radic Res. 2016 Jul 7:1 -16Sastre J., Pallardo F.V., Garcia de la Asuncion J. et al. Mitocondria, oxidative stress and aging. Free Rad Res. 2000; 32:189-198.Weinert B.T., Timiras P.S. Theories ofaging. J Appl Physiol. 2003;95:1706-1716.Bowles D.K., Torgan C.E., Ebner S., Kehrer J.P., Ivy J.L., Starnes J.W. Effects of acute, submaximal exercise on skeletal muscle vitamin E. Free Radic Res Commun. 1991;14:139-143.Vina J., Borras C., Abdelaziz K.M., Garcia-Valles R., Gomez-Cabrera M.C. The free radical theory of aging revisited: the cell signaling disruption theory of aging. Antioxid Redox Signal. 2013;19(8):779-787.Merksamer P.I., Liu Y., He W., Hirschey M.D., Chen D., Verdin E. The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY). 2013;5(3):144-150.Robert A.M., Robert L. Xanthine oxido -reductase, free radicals and cardiovascular disease. A critical review. Pathol Oncol Res. 2014;20(1):1- 10.Yarilin A.A. Osnovy immunologii. M., Medicina, 1999;668Potapnev M.P. Cytokine network of neutrophils in inflammation. M.P. Potapnev. Immunologiya. 1995;4:34-39.Dorofeev S.D., Kudryavtsev Yu.V., Kudryavtseva L.V. Immunohistochemical aspects of chronic abacterial prostatitis. Effektivnaya farmakoterapiya. 2014; 2: 26-38.Litvickij, P.F. Patofiziologiya : textbook P.F. Litvickij. 4 -e izdanie., ispravlennoe. i dopolnennoe. M.: GE’OTAR. Media 2008; 496.Serebrennikova S.N., Seminskij I.Zh.Patofiziologiya vospalitel’nogo processa. Textbook. Irkutsk, 2014; 73.Rubcovenko, A. V. Patologicheskaya fiziologiya A. V. Rubcovenko. M.: MEDpress -inform. 2006; 608.Lotti F., Maggi M. Interleukin 8 and the male genital tract. J Reprod Immunol. 2013;100(1):54-65.Song W., Li D.Y., Yuan H.C., Gu Z.H., Shao J.L., Wang X. Relationship between interleukin -8 levels in expressed prostatic secretion and expressions ofbFGF and Bcl -2 in benign prostatic hyperplasia. Zhonghua Yi Xue Za Zhi. 2016;96(2):104-107.Dinarello C.A. Proinflammatory cytokines. Chest. 2000;118(2):503-508.Hedger M.P., Meinhardt A. Cytocines and the immune -testicular axis. J Reprod Immunol. 2003;58(1):1-26.Thomas L.J., Anthony J.S. The role of cytokines in prostatitis. World J. Urol. 2003;21:95-99.Wiygul R.D. Prostatatis: epidemiology of inflammation. Curr. Urol. Rep. 2005;6(4):282-289.Perrin G.Q., Johnson H.M., Subramaniam P.S. Mechanism of interleukin -10 inhibition of T -helper cell activation by superantigen at the level of the cell cycle. Blood. 1999;93(1):208-216.Roth I., Fisher S.J. IL -10 is an autocrine inhibitor of human placental cytotrophoblast MMP -9 production and invasion. Dev Biol. 1999;205(1):194-204.Steinhauser M.L., Hogaboam C.M., Kunkel S.L., Lukacs N.W., Strieter R.M., Standiford T.J. IL -10 is a major mediator of sepsis -induced impairment in lung antibacterial host defense. J Immunol. 1999;162(1):392-399.Ajuebor M.N., Das A.M., Virag L., Szabo C., Perretti M. Regulation of macrophage inflammatory protein -1 alpha expression and function by endogenous interleukin -10 in a model of acute inflammation. Biochem Biophys Res Commun. 1999;255(2):279-282.Schwartz E.S., Xie A., La J.H., Gebhart G.F. Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis. Pain. 2015;156(8):1537-1544.Pietrzak A., Misiak-Tloczek A., Brzezinska-Blaszczyk E. Interleukin (IL)-10 inhibits RANTES -, tumour necrosis factor (TNF) - and nerve growth factor (NGF) -induced mast cell migratory response but is not a mast cell chemoattractant. Immunol Lett. 2009;123(1):46-51.Ma D., Wolvers D., Stanisz A.M., Bienenstock J. Interleukin -10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2003; 284(5): 1323-1329.Ketlinsky S.A., Kalinina N.M. Cytokines of mononuclear cells in the reaction of inflammation and immunity. Immunologiya. 1995;3:30-44.Razumov S.V., Medvedev A.A., Chirun N.V., Et al. The role of cytokines in the diapes of chronic prostatitis. Urologiia. 2003; 6: 25-28Duan Z.G., Yang W.M. Analysis of cytokines (IL -2, IL -8,IL -10) in the expressed prostatic secretions of chronic prostatitis. ZhonghuaNan Ke Xue. 2005 Mar. 11(3): 201-203.Khadra A., Fletcher P., Luzzi G. Interleukin -8 levels in seminal plasma in chronic prostatitis chronic pelvic pain syndrome and nonspecific urethritis. BJU Int. 2006 May. 97(5): 1043-1046.Paulis G., Conti E., Voliani S. et al. Evaluation of the cytokines in genital secretions of patients with chronic prostatitis. Arch.Ital.UroLAndrol. 2003; 75(4): 179-186.Jang T.L., Schaeffer A.J. The role of cytokines in prostatitis World J. Urol. 2003;21(2):95-99.Kramer G., Marberger M. Could inflammation be a key component in the progression of benign prostatic hyperplasia? Curr. Opin. Urol. 2006;16(1): 25-29.Li S.P., Meng S.Y., Li R. Clinical evaluation of four cytokines in serum and prostatic fluid in chronic abacterial prostatitis. Zhonghua Nan Ke Xue. 2006; 12(l): 25-27.Penna G., Mondaini N., Amuchastegui S., Degli Innocenti S., Carini M., Giubilei G., Fibbi B., Colli E., Maggi M., Adorini L. Seminal plasma Cytokines and Chemokines in Prostate Inflammation: Interleukin-8 as a Predictive Biomarker in Chronic Prostatitis Chronic Pelvic Pain Syndrome and Benign Prostatic Hyperplasia. Eur. Urol. 2007;2:524-33.Haverkamp J.M., Charbonneau B., Crist S.A., Meyerholz D.K., Cohen M.B., Snyder P.W., Svensson R.U., Henry M.D., Wang H.H., Ratliff T.L. An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate. Prostate. 2011 Aug 1;71(11):1139-1150.Ding X.G., Li S.W., Zheng X.M., Hu L.Q. IFN -gamma and TGF -beta1, levels in the expressed prostatic secretions of patients with chronic abacterial prostatitis. Zhonghua Nan Ke Xue. 2006;12(11):982-984.Chen L., Xia W.P., Zhou Z.H. Morphological and proinflammatory expression of the experimental autoimmune prostatitis in the rat model. Zhonghua Nan Ke Xue. 2007;13(5):444-448.Hua V.N., Schaeffer A.J. Acute and chronic prostatitis. Med. Clin. North. Am. 2004;88:483-494.Moon T.D. Immunology of chronic prostatitis: etiological and therapeutic considerations. Curr. Op. Urol. 1998;8:39-43.Shahed A.R., Shoskes D.A. Correlation of [beta] -endorphin and prostaglandin E2 levels in prostate of patients with chronic prostatitis with diagnosis and treatment response. J. Urol. 2001;166:1738-1741.Shoskes D.A., Albakri Q., Thomas K., Cook D. Cytokine polymorphisms in men with chronic prostatitis chronic pelvic pain syndrome: association with diagnosis and treatment response. J. Urology. 2002;168:331-335.Alexander R.B., Ponniah S., Hasday J., Rebel J.R. Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis chronic pelvic pain syndrome. Urol. 1998;52:744-749.Hochreiter W.W., Nadler R.B., Koch A.E. Diagnostic value of serial cytokine changes in expressed prostatic secretions. J. Urol. 2000;163:24.Hochreiter W.W., Nadler R.B., Koch A.E., Campbell P.L., Ludwig M., Weidner W., Schaeer A J. Evaluation of the cytokines: interieukin -8 and epithelial neutrophil activating peptide 78 as indicators of inanition in prostatic secretions. Urology. 2000;56:1025-1029.Nadler R.B., Koch A.E., Calhoun E.A., Campbell P.L., Pruden D.L., Bennett C.L., Yarnold P.R., Schaeffer A.J. IL-1 [beta] and TNF -[alpha] in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. J. Urol. 2000;164:214-218.Miller L.J., Fischer K.A., Goralnick S.J., Litt M., Burleson J.A., Albertsen P., Kreutzer D.L. Interleukin-10 levels in seminal plasma: implications for chronic prostatitis - chronic pelvis pain syndrome. J. Urol. 2002;167:753-756.Miller L.J., Fischer K.A., Goralnick S.J., Litt M., Burleson J.A., Albertsen P., Kreutzer D.L. Nerve growth factor and chronic prostatitis chronic pelvic pain syndrome Urology. 2002;59(4):603-608.Bobkov Yu.A, Al’ -shukri S.X., Gorbachev A.G., Galkina O.V., Kozlov V.V., Totolyan A.A. Informativnost’ pokazatelej mestnogo immuniteta pri xronicheskom prostatite. Medicinskaya immunologiya. 2000;4(2):401-408.Sadretdinov R.A., Polunin A.A., Asfandiyarov F.R. Analysis of the level of interleukin-8 in chronic prostatitis. International Journal of Experimental Education. 2015;3:69-70.Totolyan A.A., Al-Shukri S.Kh., Kozlov V.V. Diagnostic significance of the definition of interleukin-8 in chronic prostatitis. Urologiia. 2001;6:6-8.Konoplya A.I., Teodorovich O.V., Shatokhin M.N., Gavrilyuk V.P., Mavrin M.Yu. Chronic prostatitis, prostate adenoma and immunity: disorders and correction. Urologiia. 2013;4:99-103.Neimark B.A., Neimark A.I., Davydov A.V., Klepikova 1.1., Nozdrachev N.A., Razdorska M.V. The role of cytomedins in the treatment of patients with chronic prostatitis, accompanied by impaired spermatogenesis. Urologiia. 2015;5:70-3.Repin E.V. Dynamics of immunological changes in patients with bacterial and abacterial chronic prostatitis on the background of traditional therapy. Tsitokiny i vospalenie. (Cytokines and inflammation). 2009;8(2):22- 26.