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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Urologiia</journal-id><journal-title-group><journal-title xml:lang="en">Urologiia</journal-title><trans-title-group xml:lang="ru"><trans-title>Урология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-2985</issn><issn publication-format="electronic">2414-9020</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">636302</article-id><article-id pub-id-type="doi">10.18565/urology.2024.4.97-102</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Наблюдения из практики</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Stent-associated urosepsis, personalized bacteriophage therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Стент-ассоциированный уросепсис, персонализированная бактериофаготерапия</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Perepanova</surname><given-names>T. S.</given-names></name><name xml:lang="ru"><surname>Перепанова</surname><given-names>Т. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, MD, Professor, Head of Infectious and Inflammatory Diseases and Clinical Pharmacology Panel of the Department of General and Reconstructive Urology</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, зав. отделом инфекционно-воспалительных заболеваний и клинической фармакологии</p></bio><email>perepanova2003@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3198-5933</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazachenko</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Казаченко</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, MD, Deputy Director of Clinical Work</p></bio><bio xml:lang="ru"><p>д.м.н., заместитель директора по лечебной работе</p></bio><email>avknii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mesropyan</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Месропян</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acting Head of the Department of Anesthesiology and Resuscitation</p></bio><bio xml:lang="ru"><p>и.о. заведующего отделением анестезиологии и реанимации</p></bio><email>perepanova2003@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Antonova</surname><given-names>V. E.</given-names></name><name xml:lang="ru"><surname>Антонова</surname><given-names>В. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Head of the Transfusiology Department</p></bio><bio xml:lang="ru"><p>к.м.н., заведующая отделением трансфузиологии</p></bio><email>perepanova2003@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nazirov</surname><given-names>M. R.</given-names></name><name xml:lang="ru"><surname>Назиров</surname><given-names>М. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head of the Clinical and Diagnostic Laboratory</p></bio><bio xml:lang="ru"><p>заведующий клинико-диагностической лабораторией</p></bio><email>nazirov84@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malova</surname><given-names>Yu. A.</given-names></name><name xml:lang="ru"><surname>Малова</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Specialist of Organizational and Methodological Department</p></bio><bio xml:lang="ru"><p>специалист организационно-методического отдела</p></bio><email>perepanova2003@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lyubchenko</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Любченко</surname><given-names>Л. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, MD, Professor, Head of the Department of Molecular Genetics and Cellular Technologies</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, заведующая отделом молекулярной генетики и клеточных технологий</p></bio><email>perepanova2003@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center</institution></aff><aff><institution xml:lang="ru">НИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ФГБУ «НМИЦ радиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-09-21" publication-format="electronic"><day>21</day><month>09</month><year>2024</year></pub-date><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>97</fpage><lpage>102</lpage><history><date date-type="received" iso-8601-date="2024-09-20"><day>20</day><month>09</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-09-20"><day>20</day><month>09</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО «Бионика Медиа»</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/1728-2985/article/view/636302">https://journals.eco-vector.com/1728-2985/article/view/636302</self-uri><abstract xml:lang="en"><p>In the era of antibiotic resistance, strict control of foci of infection (for example, a long-term stent) and adherence to the timing of drainage removal are necessary.</p> <p>The spread of pan-resistant pathogens requires the development of effective alternative antimicrobial measures, in particular, bacteriophage therapy.</p> <p>A clinical case of a 42-year-old patient with a closed spinal cord injury, lower paraplegia, pelvic organs dysfunction, post-traumatic right ureteral stricture, and right kidney stones is presented in the article.</p> <p>The patient developed stent-associated urosepsis due to pan-resistant Klebsiella pneumonia after endoscopic removal of a long-term right ureteral stent (over 3 months) with endotoxic shock, disseminated intravascular coagulation syndrome and wound sepsis, which was treated using personalized local bacteriophage therapy.</p></abstract><trans-abstract xml:lang="ru"><p>В эру антибиотикорезистентности необходимы строгий контроль очагов инфекции в организме (например, длительно находящийся стент), строгое соблюдение сроков дренирования мочевых путей. Распространение панрезистентных возбудителей урологической инфекции требует разработки эффективных альтернативных антимикробных методов лечения, в частности бактериофаготерапии. В статье представлено клиническое наблюдение пациентки 42 лет с закрытой позвоночно-спинномозговой травмой, нижней параплегией, нарушением функции тазовых органов, посттравматической стриктурой правого мочеточника, мочекаменной болезнью, камнями правой почки. После удаления длительно находящегося внутреннего стента (самоудерживающийся катетер) (свыше 3 мес.) у пациентки развился стент-ассоциированный уросепсис пан-резистентной Klebsiella pneumonia с эндотоксическим шоком, синдромом диссеминированного внутрисосудистого свертывания (ДВС) и раневым сепсисом, который удалось купировать благодаря персонализированной местной бактериофаготерапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>stent-associated urosepsis</kwd><kwd>bacteriophage therapy</kwd><kwd>bacteriophages</kwd><kwd>antibiotic resistance</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>стент-ассоциированный уросепсис</kwd><kwd>бактериофаготерапия</kwd><kwd>бактериофаги</kwd><kwd>антибиотикорезистентность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Paick S.H., Park H.K., Oh S.J., Kim H.H. 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