Molecular mechanisms of male infertility: main directions of scientific research
- Authors: Galimov S.N1, Gromenko Y.Y.2, Galimov K.S.3, Galimova E.F1, Bodrova E.S3, Bulygin K.V3,4, Litvitsky P.F3
-
Affiliations:
- Bashkir StateMedical University
- Medical Center Family
- I.M.Sechenov First Moscow State Medical University (Sechenov University)
- M.V.Lomonosov Moscow State University
- Issue: No 4 (2022)
- Pages: 114-117
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/277210
- DOI: https://doi.org/10.18565/urology.2022.4.114-117
- ID: 277210
Cite item
Abstract
Keywords
Full Text
About the authors
S. N Galimov
Bashkir StateMedical University
Email: sngalim@mail.ru
MD, PhD, DSc, Professor, Head of the Department of Biological Chemistry
Yu. Yu Gromenko
Medical Center Family
Email: info@medufa.ru
MD, PhD, Head Physician
K. Sh Galimov
I.M.Sechenov First Moscow State Medical University (Sechenov University)
Email: sngalim@mail.ru
Student, N.V. Sklifosovsky Institute of Clinical Medicine
E. F Galimova
Bashkir StateMedical University
Email: efgalimova@mail.ru
MD, Professor of the Department of Pathological Physiology
E. S Bodrova
I.M.Sechenov First Moscow State Medical University (Sechenov University)
Email: elizaveta5976@mail.ru
student of the Institute of Clinical Medicine named after N.V. Sklifosovsky
K. V Bulygin
I.M.Sechenov First Moscow State Medical University (Sechenov University); M.V.Lomonosov Moscow State University
Email: kirill-bh-red@yandex.ru
MD, PhD, Associate Professor of the Department of Human Anatomy; Associate Professor at the Department of Normal and Topographic Anatomy
P. F Litvitsky
I.M.Sechenov First Moscow State Medical University (Sechenov University)
Email: litvitskiy_p_f@staff.sechenov.ru
MD, PhD, DSc, Professor, Head of the Department of Pathophysiology
References
- Baskaran S., Agarwal A., Leisegang K., Pushparaj P., Panner Selvam M., Henkel R. An In-Depth Bibliometric Analysis and Current Perspective on Male infertility Research.World. J. Mens. Health. 2021;39(2):302-314. doi: 10.5534/wjmh.180114.
- Agarwal A., Mulgund A., Hamada A., Chyatte M. A unique view on male infertility around the globe. ReprodBiolEndocrinol. 2015;13:37. doi: 10.1186/s12958-015-0032-1.
- Pavlov V.N., Galimova E.F., Akhmadullina G.H., Galimov Sh.N. Medico-biological, social, cultural and educational aspects of men’s health protection. Preventive and clinical medicine. 2014;2(51):5-13. Russan (Павлов В.Н., Галимова Э.Ф., Ахмадуллина Г.Х., Галимов Ш.Н. Медико-биологические, социальные и культурно-образовательные аспекты охраны мужского здоровья. Профилактическая и клиническая медицина. 2014;2(51):5-13).
- Lebedev G.S., Golubev N.A., Shaderkin I.A., Shaderkina V.A., Apolikhin O.I., Sivkov A.V. Male infertility in the Russian Federation: statistical data for 2000 2018 Experimental and clinical urology. 2019;4:4-12. Russoan (Лебедев Г.С., Голубев Н.А., Шадеркин И.А., Шадеркина В.А., Аполихин О.И., Сивков А.В. Мужское бесплодие в Российской Федерации: статистические данные за 2000-2018 гг. Экспериментальная и клиническая урология. 2019;4:4-12). doi: 10.29188/2222-8543-2019 11-4-4-12.
- Houston B., Riera-Escamilla A., Wyrwoll M., Salas-Huetos A., Xavier M., Nagirnaja L. et al. A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. Hum. Reprod. Update. 2021:dmab030. doi: 10.1093/humupd/dmab030.
- Aitken R. The Male Is Significantly Implicated as the Cause of Unexplained Infertility. Semin. Reprod. Med. 2020;38(1):3-20. doi: 10.1055/s-0040-1718941.
- Shiraishi K. Genome medicine in male infertility: From karyotyping to single-cell analysis. J. Obstet. Gynaecol. Res. 2021;47(8):2586-2596. doi: 10.1111/jog.14828.
- Pavlov V.N., Galimova E.F., Teregulov B.F., Kaibyshev V.T., Galimov S.N. Molecular and metabolic aspects of male infertility. Bulletin of Urology. 2016;2:40-49. Rusian (Павлов В.Н., Галимова Э.Ф., Терегулов Б.Ф., Кайбышев В.Т., Галимов Ш.Н. Молекулярные и метаболические аспекты мужского бесплодия. Вестник урологии. 2016;2:40-49).
- Craig J., Jenkins T., Carrell D., Hotaling J. Obesity, male infertility, and the sperm epigenome. Fertil. Steril. 2017;107:848-859. Doi: 10.1016/j. fertnstert.2017.02.115.
- Ilacqua A., Izzo G., PietroEmerenziani G., Baldari C., Aversa A. Lifestyle and fertility: the influence of stress and quality of life on male fertility. Reprod. Biol. Endocrinol. 2018;16:115. doi: 10.1186/s12958-018-0436-9.
- Agarwal A., Baskaran S., Parekh N. et al. Male infertility. Lancet. 2021;397(10271):319-333. doi: 10.1016/S0140-6736(20)32667-2.
- Salas-Huetos A., Aston K.I. Defining new genetic etiologies of male infertility: progress and future prospects. Transl. Androl. Urol. 2021;10(3):1486-1498. doi: 10.21037/tau.2020.03.43.
- Krausz C., Riera-Escamilla A. Genetics of male infertility. Nat. Rev. Urol. 2018;15:369-384. doi: 10.1038/s41585-018-0003-3.
- Aitken R., Drevet J. The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword. Antioxidants. 2020;9:111. doi: 10.3390/antiox9020111.
- Lord T., Aitken R. Fertilization stimulates 8-hydroxy-2’-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo. Dev. Biol. 2015;406:1-13. doi: 10.1016/j.ydbio.2015.07.024.
- Xavier M., Nixon B., Roman S., Scott R., Drevet J., Aitken R. Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa. Hum Reprod. 2019;34:1876-1890. doi: 10.1093/humrep/dez153.
- Aitken R., Baker M. The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility - A Unifying Hypothesis? Front. Endocrinol. 2020;11:581838. doi: 10.3389/fendo.2020.581838/.
- Galimov Sh., Gromenko J., Bulygin K., Galimov K., Galimova E., Sinelnikov M. The level of secondary messengers and the redox state of NAD+/NADH are associated with sperm quality in infertility. J. Reprod. Immunol. 2021;148:103383. doi: 10.1016/j.jri.2021.103383.
- Baskaran S., Finelli R., Agarwal A., Henkel R. Reactive oxygen species in male reproduction: A boon or a bane? Andrologia. 2021;53(1):e13577. doi: 10.1111/and.13577.
- Гяургиев Т.А., Кузьменко А.В., Кузьменко В.В. Современный взгляд на применение антиоксидантов в терапии мужского бесплодия. 2020;6:142-147. doi: 10.18565/urology.2020.6.142-147.
- Cannarella R., Condorelli R., Mongioi L., La Vignera S., Calogero A. Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility. Int. J. Mol. Sci. 2020;21(5):1728. doi: 10.3390/ijms21051728.
- Lombo M., Ruiz-Diaz S., Gutierrez-Adan A., SanchezCalabuig M. Sperm Metabolomics through Nuclear Magnetic Resonance Spectroscopy. Animals (Basel). 2021;11(6):1669. doi: 10.3390/ani11061669.
- McSwiggin H., O’Doherty A. Epigenetic reprogramming during spermatogenesis and male factor infertility. Reproduction. 2018;156:9-21. doi: 10.1530/REP-18-0009.
- Rotondo J., Lanzillotti C., Mazziotta C. et al. Epigenetics of Male Infertility: The Role of DNA Methylation. Front. Cell Dev. Biol. 2021;9:689624. doi: 10.3389/fcell.2021.689624.
- Sarkar S., Sujit K., Singh V., Pandey R., Trivedi S., Singh K. Array-based DNA methylation profiling reveals peripheral blood differential methylation in male infertility. FertilSteril. 2019;112(1):61-72.e1. Doi: 10.1016/j. fertnstert.2019.03.020.
- Barbu M., Thompson D., Suciu N., Voinea S., Cretoiu D., Predescu D. The Roles of MicroRNAs in Male Infertility. Int. J. Mol. Sci. 2021;22(6):2910. doi: 10.3390/ijms22062910.
- Eikmans M., Anholts J., Blijleven L., Meuleman T., van Beelen E., van der Hoorn M. Optimization of microRNA Acquirement from Seminal Plasma and Identification of Diminished Seminal microRNA-34b as Indicator of Low Semen Concentration. Int. J. Mol. Sci. 2020;21(11):4089. doi: 10.3390/ijms21114089.
- Wang C., Yang C., Chen X., Yao B., Yang C., Zhu C. et al. Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin. Chem. 2011;57(12):1722-1731. doi: 10.1373/clinchem.2011.169714.
- Mostafa T., Rashed L., Nabil N., Osman I. Mostafa R. Farag M. Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele. Biomed. Res. Int. 2016;2016:4302754. doi: 10.1155/2016/4302754.
- Tian H., Lv M., Li Z., Peng D., Tan Y., Wang H. et al. Semen-specific miRNAs: Suitable for the distinction of infertile semen in the body fluid identification? Forensic Sci. Int. Genet. 2018;33:161-167. Doi: 10.1016/j. fsigen.2017.12.010.
- Corral-Vazquez C., Salas-Huetos A., Blanco J., Vidal F., Sarrate Z., Anton E. Sperm microRNA pairs: new perspectives in the search for male fertility biomarkers. FertilSteril. 2019;112(5):831-841. Doi: 10.1016/j. fertnstert.2019.07.006.
- Галимова Э.Ф., Павлов В.Н., Абдуллина А.З., Галимов Ш.Н. Особенности ферментного профиля и энергетического статуса спермальной плазмы при идиопатическом бесплодии. Проблемы репродукции. 2013;1:66-69
- Park Y., Pang M. Mitochondrial Functionality in Male Fertility: From Spermatogenesis to Fertilization. Antioxidants (Basel). 2021;10(1):98. doi: 10.3390/antiox10010098.
- Громенко Ю.Ю., Галимова Э.Ф., Громенко Д.Д., Галимов К.Ш., Булыгин К.В., Галимов Ш.Н. Активация ооцитов: фундаментальные и клинические аспекты. Вопросы гинекологии, акушерства и перинатологии. 2020;19(5):77-85. doi: 10.20953/17261678-2020-5-77-85.
- Cardona Barberan A., Boel A., VandenMeerschaut F., Stoop D., Heindryckx B. Diagnosis and Treatment of Male Infertility-Related Fertilization Failure. J.Clin. Med. 2020;9(12):3899. doi: 10.3390/jcm9123899.
- Meng X., Melo P., Jones C., Ross C., Mounce G., Turner K. et al. Use of phospholipase C. zeta analysis to identify candidates for artificial oocyte activation: a case series of clinical pregnancies and a proposed algorithm for patient management. FertilSteril. 2020;114(1):163-174. Doi: 10.1016/j. fertnstert.2020.02.113.
- Kumar N., Singh N. Emerging role of Novel Seminal Plasma Biomarkers in Male Infertility: A Review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020;253:170-179. doi: 10.1016/j.ejogrb.2020.08.015.
- Галимов Ш.Н., Божедомов В.А., Галимова Э.Ф., Павлов В.Н., Сухих Г.Т. Мужское бесплодие: молекулярные иммунологические аспекты. М.: ГЭОТАР-Медиа. 2020; 208 с.