A clinical case of bladder metastasis of skin melanoma

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Abstract

Melanoma is the most aggressive malignant skin neoplasm with a high potential for metastasis and molecular genetic diversity.

A clinical case of a 35-year-old patient who admitted to the clinic with a diagnosis of melanoma of the skin on the back of pT2aN2M1b, Clarke invasion stage 3, BRAF (+), metastases to the brain, spine (Th8), who had previously undergone to complete excision of melanoma in 2023, is presented in the article. During examination, bladder tumor was detected. Histological study confirmed the presence of metastatic melanoma of the bladder.

Metastatic bladder tumor in patients with melanoma is a rare entity. Surgical treatment can be carried out to improve dysuria and the oncological outcomes, including those patients with synchronous metastases.

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About the authors

I. A. Aboyan

CDC «Zdorovie»

Email: aboyan@center-zdorovie.ru
ORCID iD: 0000-0002-2798-368X

Ph.D., MD, professor

Russian Federation, Rostov-on-Don

D. I. Pakus

GBU RO Oncologic dispensary

Author for correspondence.
Email: sergejj.pakus@rambler.ru

Ph.D., Chief

Russian Federation, Rostov-on-Don

S. M. Pakus

CDC «Zdorovie»

Email: sergejj.pakus@rambler.ru
ORCID iD: 0000-0001-6468-5983

Ph.D., head of the oncourology Department

Russian Federation, Rostov-on-Don

K. A. Shiranov

CDC «Zdorovie»

Email: urologgg@mail.ru
ORCID iD: 0000-0002-2752-4395

Ph.D., urologist at the Department of urology

Russian Federation, Rostov-on-Don

S. I. Lemeshko

CDC «Zdorovie»

Email: sergejj.pakus@rambler.ru

Ph.D., Head of the Department of Pathology of Central Diagnostic Laboratory

Russian Federation, Rostov-on-Don

References

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Supplementary files

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2. Fig. 1. Tomogram (MPT) of the pelvic organs: a round formation measuring 32x35x24 mm

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3. Fig. 2. Cystoscopic picture. Formation of the urinary bladder

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4. Fig. 3. Cystoscopic picture. Stage of laser en-block resection of the bladder formation. "Removed tumor bed"

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5. Fig. 4. Macroscopic specimen of the removed tumor

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6. Fig. 5 (A-B). Histological examination data. A. Tumor cells containing brown pigment in the cytoplasm. Magnification ×100. Hematoxylin and eosin staining

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