Comparative analysis of the results of morphological examination of hyperplastic prostate tissue in patients with and without testosterone deficiency

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Introduction. Benign prostatic hyperplasia (BPH) is an important and urgent public health problem. Prostatic hyperplasia is characterized by epithelial, stromal, and muscular proliferation.

Objective. To conduct a comparative analysis of the results of morphological examination of resected prostate tissue in patients with prostatic hyperplasia with and without testosterone deficiency.

Materials and Methods. The results of morphological examination of the resected prostate tissue of 188 men with BPH were analyzed, who were divided into two groups: Group I – 71 patients with testosterone deficiency, group II (control) – 117 patients with testosterone levels above 12.1 nmol/L.

Results. In patients with testosterone deficiency, during morphological examination of resected pancreatic tissue samples, prostate hyperplasia had a diffuse stromal character, combined with cystic deformity of the acinuses, with flattened and unclassifying epithelium, against the background of basal cell hyperplasia. In patients with normal Tc levels during morphological examination, during morphological examination of resected pancreatic tissue samples, the hyperplasia in all patients was glandular (epithelial), and the epithelial cells of the acinuses were tall cylindrical, with signs of active secretion.

Conclusion. In hypogonadal men, stromal hyperplasia was detected in most cases (76.1%) in the resected prostate tissue, and in normogonadal patients, hyperplasia was glandular in all cases.

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作者简介

Khalid Ibishev

Rostov State Medical University

编辑信件的主要联系方式.
Email: ibishev22@mail.ru
ORCID iD: 0000-0002-2954-842X

Dr. Sc. (Med.), Professor at the Department of Urology and Human Reproductive Health (with a Course of Pediatric Urology and Andrology)

俄罗斯联邦, 29, Nakhichevansky Lane, Rostov-on-Don, 344022

Svetlana Lemeshko

Health Clinical and Diagnostic Centre

Email: lemeshko_lana@mail.ru
ORCID iD: 0009-0003-0431-7902

Cand. Sc. (Med.), Morphologist

俄罗斯联邦, 70/3, Dolomanovsky Lane, Rostov-on-Don, 344011

Magomed-Khadzhi Uzhakhov

Rostov State Medical University

Email: magamaas@mail.ru
ORCID iD: 0000-0001-7912-2649

Postgraduate Student at the Department of Urology and Human Reproductive Health (with a Course of Pediatric Urology and Andrology)

俄罗斯联邦, 29, Nakhichevansky Lane, Rostov-on-Don, 344022

Mikhail Kogan

Rostov State Medical University

Email: dept_kogan@mail.ru
ORCID iD: 0000-0002-1710-0169

Honored Scientist of the Russian Federation, Dr. Sc. (Med.), Professor, Head of the Department of Urology and Human Reproductive Health (with a Course of Pediatric Urology and Andrology)

俄罗斯联邦, 29, Nakhichevansky Lane, Rostov-on-Don, 344022

参考

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2. Fig. 1. Nature of hyperplasia in morphological examination (Group I)

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3. Fig. 2. Prostate hyperplasia with a predominance of the stromal component. Hematoxylin and eosin staining. Magnification ×100 (Group I)

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4. Fig. 3. Stromal hyperplasia of the prostate. Pronounced fibrosis. Absence of vascular structures (Group I). Stained with hematoxylin and eosin. Magnification ×100

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5. Fig. 4. Histological picture of gynerylasia of the prostate gland (Group I). The epithelium of the acinar structures is atrophic (A). The stromal component is pronounced (B). There is no glandular proliferation. Isolated muscle elements. Stained with hematoxylin and eosin. Magnification ×100

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6. Fig. 5. Histological picture of glandular atypia of the prostate (Group II). Pronounced hyperplasia of acinar structures (A), glandular component (B). Secretory epithelial cells are tall. Stained with hematoxylin and eosin. Magnification ×200

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7. Fig. 6. Histological picture of PH hyperplasia (Group II). Pronounced hyperplasia of acinar structures (A), glandular component (B) predominates over stromal. Stromal elements are dichotic. Secretory epithelial cells are tall (B). Stained with hematoxylin and eosin. Magnification ×400

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8. Fig. 7. Features of the histological picture of PZ hyperplasia in patients in Group II. Glandular hyperplasia. Hyperplasia of acinar structures, glandular component. High secretory epithelial cells. Stained with hematoxylin and eosin. Magnification ×100

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