Non-neurogenic activators of myocyte contraction and their role in the realization of the accumulative-evacuating functions of the urinary bladder

The search for and use of aIternative biomarkers of the hyperactive bIadder has garnered increasing attention in recent years because they may be considered pathogeneticaIIy significant and used as surrogate biomarkers. Promising agents that have met these criteria include proteins cytokines, neurotrophins, tumor necrosis factor (TNFa), nerve growth factor (NGF), fibrinopeptides A and B, C-reactive protein, membrane-bound ATPase. AnaIysis of current scientific Iiterature has demonstrated that specialists in many fields of medicine show interest in endogenous proteins that do not belong to neurotransmitters but affect the contractile ability of myocytes. The presented data indicate the feasibiIity and prospects of their use, but further studies and evaIuation are needed. Based on the present Iiterature review, the authors concIude that endogenous proteins activating myocyte contractiIity are of great cIinicaI vaIue as promising markers for detecting detrusor overactivity, its severity, and evaIuation of the treatment effectiveness. The authors suggest that proteins of this group can pIay an important roIe not onIy in the pathogenesis ofbladder function disorders but also in the physiological process ofurination as an additional non-neurogenic humeral component.

non-neurogenic, activators, contractility, detrusor Authors declare no conflict of interests for this article