The use of herbal supplement Renotinex based on terpenes for the complex treatment of patients with urinary stone disease

Aim: to evaluate the efficiency of dietary supplements Renotinex® for the complex treatment of patients with urinary stone disease who undergone to extracorporeal shock wave lithotripsy (ESWL). Materials and methods: a total of 60 patients with uncomplicated form of the urinary stone disease with the first stone episode (of size up to 1 cm) were evaluated. Patients were divided into two groups of 30 people and treated by ESWL. In the first group, patients additionally received Renotinex®. In the second group, standard complex therapy (antispasmodics, analgesics, non-steroidal anti-inflammatory drugs) was prescribed. The urinary level of β2-microglobulin and serum level of tocopherol were considered as markers of damage and inflammation. Pain intensity was assessed using visual analogue scale. Follow-up studies were carried out on the 1st, 7th and 14th day of therapy. Duration of treatment and follow-up was 1 month. The average number of ESWL sessions was 2.6 in both groups. Results: according to the study, it was established that components of Renotinex® had antiseptic, antispasmodic, anti-inflammatory effects on the genitourinary system, enhancing renal blood flow and decreasing the permeability of the kidney capillaries. In addition, Renotinex® has diuretic effect and nephroprotective effect, and improves renal function, alleviating aggressive therapeutic influence of ESWL. Antioxidant and nephroprotective effect are among the main mechanisms of action of Renotinex®. Conclusion: In patients who received Renotinex® as dietary supplements fragments after ESWL pass twice as fast, while in patients who did not receive Renotinex®, there was more pronounced damage to the kidney parenchyma diagnosed by urine level of β2-microglobulin. The serum concentration of vitamin E increases, while taking Renotinex®, which may prevent the peroxidation of polyunsaturated lipids in cell membranes and enhances the nephroprotective effect of Renotinex®.

urinary stone disease, terpens, renotinex, nephroprotective effect, extracorporeal shock wave lithotripsy, alpha-tocopherol acetate, beta- 2-microglobulin