BIOMARKERS OF ACUTE HYPOXIA-REOXYGENATION INJURY TO NERCYCITES DURING LAPAROSCOPIC RESECTION OF RENAL PARENCHYMA


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Resumo

Intraoperative occlusion of the renal artery during laparoscopic partial nephrectomy results in warm ischemia and nonspecific hypoxia-reoxygenation alteration of the renal parenchyma cells with a predominant injury to epitheliocytes of the proximal segments of the tubular nephron system. The onset and development ofacute kidney injury (AKI) syndrome, which requires immediate correction, is due to the typical pathological process of cell injury. In this regard, the issue of timely diagnosis of AKI remains highly relevant. In patients at high risk of developing acute renal failure, detection of AKI biomarkers enables early diagnosis. In cases with hypoxia-reoxygenation mediated destruction of epithelial cells of tt. renales, related to warm ischemia, the quality of diagnosis is significantly improved if the standard work-up is supplemented by measurements of the concentration and/or activity of cystatin C, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid binding protein, N-acetyl -β-glucosaminidase, glutathione S-transferase α-isoform, γ-glutamyl transpeptidase and lactate dehydrogenase. This article provides an overview of published evidence on the properties and diagnostic capabilities of biomarkers of warm ischemia related AKI.

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Sobre autores

S. Popov

St. Luke’s Clinical Hospital

Email: doc.popov@gmail.ru
Dr.Med.Sci., Prof. St. Petersburg, Russia

R. Guseinov

A.I. Burnazyan SSC FMBC, FMBA of Russia

Email: rusfa@yandex.ru
Urologist Moscow, Russia

A. Martov

A.I. Burnazyan SSC FMBC, FMBA of Russia

Email: martovalex@mail.ru
Dr.Med.Sci., Prof., Head of Department of Urology Moscow, Russia

T. Muratov

Akmola Regional Hospital No. 2

Email: cln-rkb@akmzdrav.kz
Urologist, Physician of the Highest Category, Chief Physician Astana, Kazakhstan

N. Tabynbaev

National Scientific Center of Oncology and Transplantology

Email: kense.777@mail.ru
Dr.Med.Sci., Prof., Chairman of the Board Astana, Kazakhstan

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